Choline Salicylate Magnesium Salicylate Brand Names- Tricosal | Trilisate
What is Choline Salicylate Magnesium Salicylate
Choline salicylate and magnesium salicylate, non-acetylated salicylates, are nonsteroidal anti-inflammatory agents that also possess antipyretic and analgesic properties.
Choline and magnesium salicylate combinations are indicated for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, and osteoarthritis and for the relief of pain and fever.
Choline and magnesium salicylate exhibit less gastrointestinal effects than aspirin and do not have a clinically significant effect on platelet function.
Choline and magnesium salicylate products have been available prior to the formation of the FDA in 1938.
Indications
- arthralgia
- bone pain
- bursitis
- dental pain
- dysmenorrhea
- fever
- headache
- juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
- mild pain
- moderate pain
- myalgia
- osteoarthritis
- rheumatoid arthritis
- tendinitis
Side Effects
- agranulocytosis
- anaphylactoid reactions
- angioedema
- anorexia
- aplastic anemia
- azotemia
- bronchospasm
- confusion
- constipation
- dehydration
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dysgeusia
- ecchymosis
- edema
- elevated hepatic enzymes
- encephalopathy
- epistaxis
- erythema multiforme
- esophagitis
- fever
- hallucinations
- headache
- hearing loss
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- hypernatremia
- hyperuricemia
- hyperventilation
- hypoglycemia
- hypokalemia
- hypoprothrombinemia
- jaundice
- lethargy
- leukocytosis
- leukopenia
- metabolic acidosis
- nausea
- pancytopenia
- peptic ulcer
- proteinuria
- pruritus
- pulmonary edema
- purpura
- pyrosis (heartburn)
- rash
- renal papillary necrosis
- renal tubular necrosis
- respiratory depression
- Reye’s syndrome
- seizures
- thrombocytopenia
- tinnitus
- urticaria
- visual impairment
- vomiting
- weight gain
- wheezing
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum magnesium
- serum salicylate concentrations
Contraindications
- acid/base imbalance
- acute bronchospasm
- alcoholism
- anemia
- anticoagulant therapy
- ascites
- asthma
- bone marrow suppression
- breast-feeding
- coagulopathy
- dehydration
- esophagitis
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- gout
- heart failure
- hemophilia
- hepatic disease
- hypermagnesemia
- hypertension
- hypoprothrombinemia
- hypovolemia
- immunosuppression
- influenza
- labor
- metabolic acidosis
- metabolic alkalosis
- nasal polyps
- neutropenia
- obstetric delivery
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- respiratory acidosis
- respiratory alkalosis
- Reye’s syndrome
- salicylate hypersensitivity
- systemic lupus erythematosus (SLE)
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- tobacco smoking
- varicella
- viral infection
- vitamin K deficiency
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Acidifying Agents
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Angiotensin-converting enzyme inhibitors
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Ardeparin
- Ascorbic Acid, Vitamin C
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Bacitracin
- Barbiturates
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Beta-blockers
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bromocriptine
- Bumetanide
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Capreomycin
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Cefdinir
- Cefixime
- Cefotetan
- Celecoxib
- Chlorothiazide
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cidofovir
- Ciprofloxacin
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Citric Acid; Sodium Citrate
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Corticosteroids
- Cyclosporine
- Dabigatran
- Dalteparin
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Deferasirox
- Delafloxacin
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Drotrecogin Alfa
- Edoxaban
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Escitalopram
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ethanol
- Ethotoin
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Furosemide
- Gallium Ga 68 Dotatate
- Gemifloxacin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Griseofulvin
- Heparin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Immune Globulin IV, IVIG, IGIV
- Incretin Mimetics
- Indapamide
- Indomethacin
- Inotersen
- Insulins
- Ketoprofen
- Ketorolac
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Levofloxacin
- Linagliptin
- Linagliptin; Metformin
- Lisinopril
- Loop diuretics
- Low Molecular Weight Heparins
- Macimorelin
- Magnesium Citrate
- Mannitol
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Meloxicam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methazolamide
- Methotrexate
- Methyclothiazide
- Metolazone
- Moexipril
- Moxifloxacin
- Mycophenolate
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nitazoxanide
- Norfloxacin
- Ofloxacin
- Omeprazole; Sodium Bicarbonate
- Oxaprozin
- Paroxetine
- Penicillins
- Pentosan
- Perindopril
- Perindopril; Amlodipine
- Phentermine; Topiramate
- Phenytoin
- Photosensitizing agents (topical)
- Pioglitazone
- Piroxicam
- Polymyxins
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Pramlintide
- Probenecid
- Psyllium
- Quinapril
- Ramipril
- Repaglinide
- Rituximab; Hyaluronidase
- Rivaroxaban
- Rosiglitazone
- Salicylic Acid
- Saxagliptin
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Lactate
- Sodium Thiosulfate; Salicylic Acid
- Spironolactone
- Sulfinpyrazone
- Sulfonamides
- Sulfonylureas
- Sulindac
- Tacrolimus
- Telavancin
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Thiazide diuretics
- Thiazolidinediones
- Thrombin Inhibitors
- Thrombolytic Agents
- Tinzaparin
- Tolazamide
- Tolbutamide
- Tolmetin
- Topiramate
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamterene
- Tromethamine
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Vilazodone
- Vortioxetine
- Warfarin
