What is Choline Salicylate
NOTE: This product is discontinued in the US.
Choline salicylate a non-acetylated salicylate, is a nonsteroidal antiinflammatory agent that also possesses antipyretic and analgesic properties.
Choline salicylate is indicated for the treatment of rheumatoid arthritis and osteoarthritis, and for the relief of pain and fever.
Choline salicylate exhibits less gastrointestinal effects than aspirin and does not have a clinically significant affect on platelet function. The FDA first approved the first choline salicylate product in 1959.
The Arthropan® product was discontinued by the manufacturer in 1997.
Currently there are no single-agent choline salicylate products available in the US; however choline salicylate is available in combination products with magnesium salicylate.
Choline salicylate is available in other countries outside the US.
Indications
- arthralgia
- bone pain
- bursitis
- dental pain
- dysmenorrhea
- fever
- headache
- juvenile rheumatoid arthritis (JRA)
- mild pain
- moderate pain
- myalgia
- osteoarthritis
- rheumatoid arthritis
- tendinitis
Side Effects
- abdominal pain
- acneiform rash
- agranulocytosis
- anaphylactoid reactions
- angioedema
- aplastic anemia
- azotemia
- bronchospasm
- confusion
- constipation
- dehydration
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- elevated hepatic enzymes
- encephalopathy
- erythema nodosum
- fever
- gastritis
- GI bleeding
- hallucinations
- headache
- hearing loss
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- hypernatremia
- hyperuricemia
- hyperventilation
- hypoglycemia
- hypokalemia
- hypoprothrombinemia
- jaundice
- lethargy
- leukocytosis
- leukopenia
- maculopapular rash
- metabolic acidosis
- nausea
- pancytopenia
- peptic ulcer
- proteinuria
- pruritus
- pulmonary edema
- purpura
- pyrosis (heartburn)
- renal papillary necrosis
- renal tubular necrosis
- respiratory depression
- Reye’s syndrome
- seizures
- thrombocytopenia
- tinnitus
- urticaria
- visual impairment
- vomiting
- wheezing
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum salicylate concentrations
Contraindications
- acid/base imbalance
- acute bronchospasm
- alcoholism
- anemia
- anticoagulant therapy
- ascites
- bone marrow suppression
- breast-feeding
- coagulopathy
- dehydration
- esophagitis
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- gout
- heart failure
- hemophilia
- hepatic disease
- hypertension
- hypoprothrombinemia
- hypovolemia
- immunosuppression
- influenza
- labor
- metabolic acidosis
- metabolic alkalosis
- nasal polyps
- neutropenia
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- respiratory acidosis
- respiratory alkalosis
- Reye’s syndrome
- salicylate hypersensitivity
- systemic lupus erythematosus (SLE)
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- tobacco smoking
- varicella
- viral infection
- vitamin K deficiency
Interactions
No information is available regarding drug interactions associated with Choline Salicylate
