Choline Salicylate

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What is Choline Salicylate

NOTE: This product is discontinued in the US.

Choline salicylate a non-acetylated salicylate, is a nonsteroidal antiinflammatory agent that also possesses antipyretic and analgesic properties.

Choline salicylate is indicated for the treatment of rheumatoid arthritis and osteoarthritis, and for the relief of pain and fever.

Choline salicylate exhibits less gastrointestinal effects than aspirin and does not have a clinically significant affect on platelet function. The FDA first approved the first choline salicylate product in 1959.

The Arthropan® product was discontinued by the manufacturer in 1997.

Currently there are no single-agent choline salicylate products available in the US; however choline salicylate is available in combination products with magnesium salicylate. 

Choline salicylate is available in other countries outside the US.

Indications

  1. arthralgia
  2. bone pain
  3. bursitis
  4. dental pain
  5. dysmenorrhea
  6. fever
  7. headache
  8. juvenile rheumatoid arthritis (JRA)
  9. mild pain
  10. moderate pain
  11. myalgia
  12. osteoarthritis
  13. rheumatoid arthritis
  14. tendinitis

Side Effects

  1. abdominal pain
  2. acneiform rash
  3. agranulocytosis
  4. anaphylactoid reactions
  5. angioedema
  6. aplastic anemia
  7. azotemia
  8. bronchospasm
  9. confusion
  10. constipation
  11. dehydration
  12. diaphoresis
  13. diarrhea
  14. disseminated intravascular coagulation (DIC)
  15. dizziness
  16. drowsiness
  17. elevated hepatic enzymes
  18. encephalopathy
  19. erythema nodosum
  20. fever
  21. gastritis
  22. GI bleeding
  23. hallucinations
  24. headache
  25. hearing loss
  26. hepatic necrosis
  27. hepatitis
  28. hyperbilirubinemia
  29. hyperglycemia
  30. hypernatremia
  31. hyperuricemia
  32. hyperventilation
  33. hypoglycemia
  34. hypokalemia
  35. hypoprothrombinemia
  36. jaundice
  37. lethargy
  38. leukocytosis
  39. leukopenia
  40. maculopapular rash
  41. metabolic acidosis
  42. nausea
  43. pancytopenia
  44. peptic ulcer
  45. proteinuria
  46. pruritus
  47. pulmonary edema
  48. purpura
  49. pyrosis (heartburn)
  50. renal papillary necrosis
  51. renal tubular necrosis
  52. respiratory depression
  53. Reye’s syndrome
  54. seizures
  55. thrombocytopenia
  56. tinnitus
  57. urticaria
  58. visual impairment
  59. vomiting
  60. wheezing

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN
  • serum salicylate concentrations

Contraindications

  • acid/base imbalance
  • acute bronchospasm
  • alcoholism
  • anemia
  • anticoagulant therapy
  • ascites
  • bone marrow suppression
  • breast-feeding
  • coagulopathy
  • dehydration
  • esophagitis
  • G6PD deficiency
  • gastritis
  • geriatric
  • GI bleeding
  • GI disease
  • gout
  • heart failure
  • hemophilia
  • hepatic disease
  • hypertension
  • hypoprothrombinemia
  • hypovolemia
  • immunosuppression
  • influenza
  • labor
  • metabolic acidosis
  • metabolic alkalosis
  • nasal polyps
  • neutropenia
  • peptic ulcer disease
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis
  • respiratory alkalosis
  • Reye’s syndrome
  • salicylate hypersensitivity
  • systemic lupus erythematosus (SLE)
  • thrombolytic therapy
  • thrombotic thrombocytopenic purpura (TTP)
  • tobacco smoking
  • varicella
  • viral infection
  • vitamin K deficiency

Interactions

No information is available regarding drug interactions associated with Choline Salicylate

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