Lumateperone

Lumateperone Brand Name– CAPLYTA

What is Lumateperone

Lumateperone is an oral atypical antipsychotic that has a dual action as a serotonin 5-HT2A receptor antagonist and a dopamine modulator.

Lumateperone is indicated for the treatment of schizophrenia in adults. One advantage of lumateperone over most atypical antipsychotics is that dose titration is not required to reach therapeutic levels.

Similar to many other antipsychotics, clinically important CYP-mediated drug interactions may occur with lumateperone and agents that inhibit uridine 5′-diphospho-glucuronosyltransferase (UGT) also mediate clinically important interactions with this drug. As with all antipsychotics, lumateperone carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis.

Lumateperone was FDA approved in December 2019.

Indications

  • schizophrenia

Side Effects

  1. agranulocytosis
  2. akathisia
  3. anemia
  4. contact dermatitis
  5. diabetic ketoacidosis
  6. dizziness
  7. drowsiness
  8. dyskinesia
  9. dysphagia
  10. dystonic reaction
  11. elevated hepatic enzymes
  12. fatigue
  13. hypercholesterolemia
  14. hyperglycemia
  15. hyperlipidemia
  16. hyperprolactinemia
  17. hypersalivation
  18. hyperthermia
  19. hypertriglyceridemia
  20. hyponatremia
  21. hypotension
  22. hypothermia
  23. infertility
  24. leukopenia
  25. nausea
  26. neuroleptic malignant syndrome
  27. neutropenia
  28. orthostatic hypotension
  29. polydipsia
  30. pruritus
  31. pseudoparkinsonism
  32. QT prolongation
  33. rash
  34. restlessness
  35. seizures
  36. SIADH
  37. stroke
  38. syncope
  39. tardive dyskinesia
  40. tremor
  41. urticaria
  42. vomiting
  43. water intoxication
  44. weight gain
  45. xerostomia

Monitoring Parameters

  • AIMS assessment
  • blood glucose
  • CBC
  • glycosylated hemoglobin A1c (HbA1c)
  • LFTs
  • neurologic function
  • pregnancy testing
  • serum creatinine
  • serum electrolytes
  • serum lipid profile
  • serum prolactin
  • thyroid function tests (TFTs)
  • weight

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • agranulocytosis
  • ambient temperature increase
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • dehydration
  • dementia
  • diabetes mellitus
  • diabetic ketoacidosis
  • driving or operating machinery
  • dysphagia
  • ethanol ingestion
  • geriatric
  • heart failure
  • hematological disease
  • hepatic disease
  • hypercholesterolemia
  • hyperlipidemia
  • hyperthermia
  • hypertriglyceridemia
  • hypotension
  • hypothermia
  • hypovolemia
  • infants
  • infertility
  • leukopenia
  • long QT syndrome
  • myocardial infarction
  • neonates
  • neurological disease
  • neutropenia
  • obesity
  • orthostatic hypotension
  • Parkinson’s disease
  • pregnancy
  • pregnancy testing
  • QT prolongation
  • reproductive risk
  • seizure disorder
  • seizures
  • strenuous exercise
  • stroke
  • syncope
  • tardive dyskinesia

Interactions

  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Alfentanil
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amifampridine
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Armodafinil
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
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  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
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  • Butorphanol
  • Cabergoline
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  • Canagliflozin; Metformin
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  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cetrorelix
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  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Ciprofloxacin
  • Clarithromycin
  • Clemastine
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine; Probenecid
  • COMT inhibitors
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  • Cyclosporine
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  • Dabrafenib
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  • Dapagliflozin; Metformin
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  • Dexamethasone
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  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
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  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Entacapone
  • Enzalutamide
  • Erlotinib
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Etravirine
  • Exenatide
  • Fedratinib
  • Fenfluramine
  • Fentanyl
  • Flibanserin
  • Fluconazole
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Fosphenytoin
  • Fospropofol
  • Gabapentin
  • Ganirelix
  • Gemfibrozil
  • General anesthetics
  • Glecaprevir; Pibrentasvir
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Idelalisib
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  • Itraconazole
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  • Lemborexant
  • Lesinurad
  • Lesinurad; Allopurinol
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  • Levorphanol
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  • Linagliptin; Metformin
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  • Lorazepam
  • Lorlatinib
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  • Meclizine
  • Meglitinides
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methocarbamol
  • Methohexital
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  • Methylphenidate
  • Metoclopramide
  • Midazolam
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  • Morphine; Naltrexone
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  • Nortriptyline
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Opiate Agonists
  • Oritavancin
  • Orphenadrine
  • Oxazepam
  • Oxcarbazepine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Pergolide
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pioglitazone
  • Posaconazole
  • Pramipexole
  • Pramlintide
  • Prednisone
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  • Probenecid
  • Prochlorperazine
  • Promethazine
  • Propofol
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  • Quetiapine
  • Ramelteon
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  • Repaglinide
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  • Risperidone
  • Ritonavir
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Safinamide
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  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Selegiline
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  • Sevoflurane
  • SGLT2 Inhibitors
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  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • St. John’s Wort, Hypericum perforatum
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  • Sulfonylureas
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  • Tapentadol
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  • Zolpidem
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