Lumateperone Brand Name– CAPLYTA
What is Lumateperone
Lumateperone is an oral atypical antipsychotic that has a dual action as a serotonin 5-HT2A receptor antagonist and a dopamine modulator.
Lumateperone is indicated for the treatment of schizophrenia in adults. One advantage of lumateperone over most atypical antipsychotics is that dose titration is not required to reach therapeutic levels.
Similar to many other antipsychotics, clinically important CYP-mediated drug interactions may occur with lumateperone and agents that inhibit uridine 5′-diphospho-glucuronosyltransferase (UGT) also mediate clinically important interactions with this drug. As with all antipsychotics, lumateperone carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis.
Lumateperone was FDA approved in December 2019.
Indications
- schizophrenia
Side Effects
- agranulocytosis
- akathisia
- anemia
- contact dermatitis
- diabetic ketoacidosis
- dizziness
- drowsiness
- dyskinesia
- dysphagia
- dystonic reaction
- elevated hepatic enzymes
- fatigue
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hyperprolactinemia
- hypersalivation
- hyperthermia
- hypertriglyceridemia
- hyponatremia
- hypotension
- hypothermia
- infertility
- leukopenia
- nausea
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- polydipsia
- pruritus
- pseudoparkinsonism
- QT prolongation
- rash
- restlessness
- seizures
- SIADH
- stroke
- syncope
- tardive dyskinesia
- tremor
- urticaria
- vomiting
- water intoxication
- weight gain
- xerostomia
Monitoring Parameters
- AIMS assessment
- blood glucose
- CBC
- glycosylated hemoglobin A1c (HbA1c)
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine
- serum electrolytes
- serum lipid profile
- serum prolactin
- thyroid function tests (TFTs)
- weight
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- agranulocytosis
- ambient temperature increase
- breast-feeding
- cardiac disease
- cerebrovascular disease
- children
- dehydration
- dementia
- diabetes mellitus
- diabetic ketoacidosis
- driving or operating machinery
- dysphagia
- ethanol ingestion
- geriatric
- heart failure
- hematological disease
- hepatic disease
- hypercholesterolemia
- hyperlipidemia
- hyperthermia
- hypertriglyceridemia
- hypotension
- hypothermia
- hypovolemia
- infants
- infertility
- leukopenia
- long QT syndrome
- myocardial infarction
- neonates
- neurological disease
- neutropenia
- obesity
- orthostatic hypotension
- Parkinson’s disease
- pregnancy
- pregnancy testing
- QT prolongation
- reproductive risk
- seizure disorder
- seizures
- strenuous exercise
- stroke
- syncope
- tardive dyskinesia
Interactions
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Alfentanil
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amifampridine
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
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- Bexarotene
- Bosentan
- Brexpiprazole
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
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- Butorphanol
- Cabergoline
- Canagliflozin
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- Carbamazepine
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- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
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- Carbidopa; Levodopa
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- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
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- Cetirizine; Pseudoephedrine
- Cetrorelix
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- Chloral Hydrate
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
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- Codeine; Promethazine
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- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
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- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
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- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
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- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
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- Enzalutamide
- Erlotinib
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- Ertugliflozin; Metformin
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- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Estazolam
- Eszopiclone
- Ethanol
- Etomidate
- Etravirine
- Exenatide
- Fedratinib
- Fenfluramine
- Fentanyl
- Flibanserin
- Fluconazole
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gabapentin
- Ganirelix
- Gemfibrozil
- General anesthetics
- Glecaprevir; Pibrentasvir
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Idelalisib
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- Meperidine; Promethazine
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- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
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- Midazolam
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- Omeprazole; Amoxicillin; Rifabutin
- Opiate Agonists
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- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymorphone
- Paliperidone
- Pentazocine
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- Perphenazine; Amitriptyline
- Phenelzine
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