Lurasidone

Lurasidone Brand Name– Latuda

What is Lurasidone

Lurasidone is an oral atypical antipsychotic belonging to the benzisoxazole/benzoisothiazol derivatives class.

Atypical antipsychotics such as lurasidone are first-line treatment options for the management of schizophrenia and related disorders, with the exception of clozapine. Clinically, lurasidone is effective for the positive and negative symptoms of schizophrenia.

Some atypical antipsychotics, including lurasidone, have demonstrated efficacy in treating bipolar depression. Lurasidone is indicated for the treatment of schizophrenia in adults and adolescents and is also used to treat depressive episodes associated with bipolar I disorder in adults and pediatric patients 10 years of age and older.

Compared to conventional antipsychotics, atypical antipsychotics generally have a lower potential for extrapyramidal side effects. Due to extensive metabolism through CYP3A4, lurasidone is contraindicated for use with strong CYP3A4 inhibitors and strong CYP3A4 inducers.

As with all antipsychotics, lurasidone carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis

Indications

  1. behavioral or psychological symptoms of dementia
  2. bipolar depression
  3. schizophrenia

Side Effects

  1. abdominal pain
  2. abnormal dreams
  3. agitation
  4. agranulocytosis
  5. akathisia
  6. amenorrhea
  7. anemia
  8. angina
  9. angioedema
  10. anxiety
  11. appetite stimulation
  12. AV block
  13. back pain
  14. blurred vision
  15. bradycardia
  16. breast enlargement
  17. diabetes mellitus
  18. diabetic ketoacidosis
  19. diarrhea
  20. dizziness
  21. drowsiness
  22. dysarthria
  23. dyskinesia
  24. dysmenorrhea
  25. dyspepsia
  26. dysphagia
  27. dyspnea
  28. dystonic reaction
  29. dysuria
  30. fatigue
  31. galactorrhea
  32. gastritis
  33. hypercholesterolemia
  34. hyperglycemia
  35. hyperlipidemia
  36. hyperprolactinemia
  37. hypersalivation
  38. hypertension
  39. hyperthermia
  40. hypertriglyceridemia
  41. hyponatremia
  42. impotence (erectile dysfunction)
  43. infection
  44. influenza
  45. insomnia
  46. leukopenia
  47. libido decrease
  48. mastalgia
  49. nasal congestion
  50. nausea
  51. neuroleptic malignant syndrome
  52. neutropenia
  53. orthostatic hypotension
  54. pharyngitis
  55. polydipsia
  56. priapism
  57. pruritus
  58. pseudoparkinsonism
  59. QT prolongation
  60. rash
  61. renal failure (unspecified)
  62. restlessness
  63. rhabdomyolysis
  64. rhinitis
  65. rhinorrhea
  66. seizures
  67. SIADH
  68. sinus tachycardia
  69. stroke
  70. suicidal ideation
  71. syncope
  72. tardive dyskinesia
  73. urticaria
  74. vertigo
  75. vomiting
  76. water intoxication
  77. weight gain
  78. xerostomia

Monitoring Parameters

  • AIMS assessment
  • blood glucose
  • CBC
  • glycosylated hemoglobin A1c (HbA1c)
  • LFTs
  • neurologic function
  • pregnancy testing
  • serum creatinine
  • serum electrolytes
  • serum lipid profile
  • serum prolactin
  • thyroid function tests (TFTs)
  • weight

Contraindications

  • abrupt discontinuation
  • agranulocytosis
  • ambient temperature increase
  • breast cancer
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • coadministration with other CNS depressants
  • dehydration
  • dementia
  • diabetes mellitus
  • diabetic ketoacidosis
  • driving or operating machinery
  • dysphagia
  • ethanol ingestion
  • geriatric
  • heart failure
  • hematological disease
  • hepatic disease
  • hypercholesterolemia
  • hyperglycemia
  • hyperlipidemia
  • hyperprolactinemia
  • hyperthermia
  • hypertriglyceridemia
  • hypotension
  • hypothermia
  • hypovolemia
  • infertility
  • leukopenia
  • long QT syndrome
  • myocardial infarction
  • neonates
  • neurological disease
  • neutropenia
  • obesity
  • orthostatic hypotension
  • Parkinson’s disease
  • pregnancy
  • pregnancy testing
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • strenuous exercise
  • stroke
  • substance abuse
  • suicidal ideation
  • syncope
  • tardive dyskinesia

Lurasidone is contraindicated in patients with a hypersensitivity to lurasidone or any other component of the commercial product. Angioedema has been observed with lurasidone use

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Ambrisentan
  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Amprenavir
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Beta-adrenergic blockers
  • Betaxolol
  • Bexarotene
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bosentan
  • Brexpiprazole
  • Brigatinib
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Central-acting adrenergic agents
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cetrorelix
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cimetidine
  • Clarithromycin
  • Clemastine
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Conivaptan
  • Crizotinib
  • Cyclizine
  • Cyproheptadine
  • Dabrafenib
  • Danazol
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Diazoxide
  • Dicyclomine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Dulaglutide
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encorafenib
  • Entacapone
  • Enzalutamide
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Eslicarbazepine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Ethotoin
  • Etravirine
  • Exenatide
  • Fedratinib
  • Felodipine
  • Fenfluramine
  • Fenoldopam
  • Fentanyl
  • Flavoxate
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Furosemide
  • Gabapentin
  • Ganirelix
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Iloperidone
  • Iloprost
  • Imatinib
  • Incretin Mimetics
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Indinavir
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Irbesartan
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Isradipine
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Labetalol
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levodopa
  • Levorphanol
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lorlatinib
  • Losartan
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Macitentan
  • Mecamylamine
  • Meclizine
  • Meglitinides
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methscopolamine
  • Methyclothiazide
  • Methyldopa
  • Methylphenidate
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Midazolam
  • Mifepristone
  • Miglitol
  • Minoxidil
  • Mitotane
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nisoldipine
  • Nitroprusside
  • Non-Ionic Contrast Media
  • Octreotide
  • Olanzapine
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Opiate Agonists
  • Oritavancin
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Posaconazole
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prazosin
  • Pregabalin
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Propantheline
  • Propoxyphene
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Repaglinide
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Riociguat
  • Risperidone
  • Ritonavir
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Sacubitril; Valsartan
  • Safinamide
  • Saquinavir
  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Sedating H1-blockers
  • Selegiline
  • Selexipag
  • Semaglutide
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Solifenacin
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfonylureas
  • Suvorexant
  • Tadalafil
  • Tasimelteon
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Temazepam
  • Terazosin
  • Tetrabenazine
  • Thalidomide
  • Thiazide diuretics
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolcapone
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Treprostinil
  • Triamterene
  • Triazolam
  • Trifluoperazine
  • Trihexyphenidyl
  • Triprolidine
  • Trospium
  • Tucatinib
  • Valsartan
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Zafirlukast
  • Zaleplon
  • Ziprasidone
  • Zolpidem
  • Zonisamide