Lomustine CCNU

Lomustine CCNU Brand Names- CeeNU | Gleostine

What is Lomustine CCNU

Lomustine is a nitrosourea alkylating agent that is indicated for the treatment of Hodgkin lymphoma and brain cancers.

Fatal myelosuppression has been reported.

Prescribe, dispense, and administer only 1 lomustine dose at a time to minimize the risk of an overdose; lomustine is administered at a minimum of 6-week intervals

Indications

  1. acute myelogenous leukemia (AML)
  2. brain metastases
  3. Hodgkin lymphoma
  4. malignant glioma
  5. malignant melanoma
  6. non-Hodgkin’s lymphoma (NHL)

For the treatment of Hodgkin lymphoma in patients who have progressive disease following initial chemotherapy, in combination with other chemotherapeutic agents

Side Effects

  1. alopecia
  2. ataxia
  3. bleeding
  4. bone marrow suppression
  5. dysarthria
  6. elevated hepatic enzymes
  7. hyperbilirubinemia
  8. infection
  9. lethargy
  10. leukopenia
  11. nausea
  12. new primary malignancy
  13. optic atrophy
  14. pulmonary fibrosis
  15. pulmonary toxicity
  16. renal failure (unspecified)
  17. stomatitis
  18. thrombocytopenia
  19. visual impairment
  20. vomiting

Monitoring Parameters

  • CBC
  • LFTs
  • pulmonary function tests (PFTs)
  • serum creatinine/BUN
  • serum electrolytes

Contraindications

  • bleeding
  • bone marrow suppression
  • breast-feeding
  • chemotherapy
  • contraception requirements
  • hepatotoxicity
  • infection
  • infertility
  • leukopenia
  • male-mediated teratogenicity
  • nephrotoxicity
  • new primary malignancy
  • potential for overdose or poisoning
  • pregnancy
  • pulmonary disease
  • pulmonary fibrosis
  • renal failure
  • reproductive risk
  • thrombocytopenia
  • vaccination

Interactions

  • Abciximab
  • Alpha interferons
  • Alteplase
  • Amlodipine; Celecoxib
  • Anagrelide
  • Anticoagulants
  • Antithrombin III
  • Apixaban
  • Argatroban
  • Aspirin, ASA; Dipyridamole
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Budesonide
  • Budesonide; Formoterol
  • Celecoxib
  • Ciclesonide
  • Cilostazol
  • Cimetidine
  • Clopidogrel
  • Clozapine
  • Corticosteroids
  • Cortisone
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desirudin
  • Dexamethasone
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Echinacea
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Febuxostat
  • Fenoprofen
  • Filgrastim, G-CSF
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fondaparinux
  • Formoterol; Mometasone
  • Heparin
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indomethacin
  • Influenza Virus Vaccine
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Intranasal Influenza Vaccine
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lepirudin
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Methylprednisolone
  • Mometasone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nonsteroidal antiinflammatory drugs
  • Oxaprozin
  • Palifermin
  • Pegfilgrastim
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Penicillamine
  • Pentosan
  • Phenobarbital
  • Piroxicam
  • Platelet Inhibitors
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Reteplase, r-PA
  • Rivaroxaban
  • Rofecoxib
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Streptokinase
  • Sulindac
  • Tbo-Filgrastim
  • Tenecteplase
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolmetin
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Typhoid Vaccine
  • Urokinase
  • Valdecoxib
  • Varicella-Zoster Virus Vaccine, Live
  • Vorapaxar
  • Warfarin
  • Yellow Fever Vaccine, Live
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