Lomitapide Brand Name– Juxtapid
What is Lomitapide
Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor that reduces low-density lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B, and non-high-density lipoprotein (non-HDL) cholesterol in patients with homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder in which the body cannot remove LDL cholesterol from the blood.
The safety and efficacy of lomitapide have not been established in patients with hypercholesterolemia who do not have HoFH. Lomitapide binds and inhibits MTP, which prevents the assembly of apo-B-containing lipoproteins and inhibits the synthesis of chylomicrons and VLDL.
Inhibiting the synthesis of VLDL ultimately leads to reduced concentrations of LDL cholesterol in the plasma.
Lomitapide is intended for use in combination with a low-fat diet and other lipid-lowering treatments.
Lomitapide has a boxed warning regarding potential hepatotoxicity.
Prescribers, pharmacies, and patients must certify/enroll in the Juxtapid REMs program. Regular liver monitoring is required before initiation of treatment and routinely during therapy.
More information is available at www.juxtapidREMSprogram.com.
Indications
- homozygous familial hypercholesterolemia
For the reduction low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (Apo-B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH)
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- angina
- back pain
- chest pain (unspecified)
- constipation
- diarrhea
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fever
- flatulence
- gastroesophageal reflux
- headache
- hepatotoxicity
- hypovitaminosis
- influenza
- myalgia
- nasal congestion
- nausea
- palpitations
- pharyngitis
- steatosis
- tenesmus
- vomiting
- vomiting
- weight loss
Monitoring Parameters
- LFTs
- serum alkaline phosphatase
- serum bilirubin
- serum cholesterol profile
Contraindications
- breast-feeding
- contraception requirements
- dialysis
- ethanol ingestion
- hepatic disease
- hepatotoxicity
- lactase deficiency
- malabsorption syndrome
- pancreatic insufficiency
- pregnancy
- pregnancy testing
- renal failure
- renal impairment
- reproductive risk
- requires an experienced clinician
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Afatinib
- Aliskiren
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- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
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- Ethanol
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- Ethinyl Estradiol; Desogestrel
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- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
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- Ethinyl Estradiol; Norgestrel
- Everolimus
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- Fedratinib
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- Fluconazole
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- grapefruit juice
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