Lincomycin

Lincomycin Brand Name– Lincocin

What is Lincomycin

Lincomycin is a lincosamide antibiotic, structurally related to clindamycin.

Lincomycin was isolated in 1962 from a soil organism, Streptomyces lincolnensis.

Further chemical alteration resulted in the production of clindamycin, an antibiotic with greater antimicrobial activity; there is no advantage to using lincomycin over clindamycin, and lincomycin is rarely used clinically today.

Lincomycin is indicated for the treatment of serious staphylococcal, pneumococcal, and streptococcal infections in penicillin-allergic patients when treatment with less toxic agents (e.g., erythromycin) is not appropriate.

Lincomycin should be avoided in patients with an allergy to clindamycin. Complete bacterial cross resistance has been seen with clindamycin; however, partial cross resistance may also be encountered with lincomycin and agents in the macrolide class.

Susceptibility testing is recommended. As with other antibiotics, lincomycin has been associated with severe or fatal pseudomembranous colitis.

Lincomycin was FDA-approved in 1964.

Indications

  1. bacteremia
  2. Clostridium perfringens
  3. Clostridium tetani
  4. Corynebacterium diphtheriae
  5. ocular surgery
  6. Staphylococcus aureus (MRSA)
  7. Staphylococcus aureus (MSSA)
  8. Streptococcus pneumoniae
  9. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  10. Viridans streptococci

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. angioedema
  7. aplastic anemia
  8. azotemia
  9. bullous rash
  10. candidiasis
  11. cardiac arrest
  12. diarrhea
  13. dizziness
  14. drowsiness
  15. elevated hepatic enzymes
  16. erythema multiforme
  17. exfoliative dermatitis
  18. glossitis
  19. headache
  20. hypotension
  21. injection site reaction
  22. jaundice
  23. leukopenia
  24. nausea
  25. neutropenia
  26. oliguria
  27. pancytopenia
  28. phlebitis
  29. proteinuria
  30. pruritus
  31. pruritus ani
  32. pseudomembranous colitis
  33. rash
  34. serum sickness
  35. Stevens-Johnson syndrome
  36. stomatitis
  37. superinfection
  38. thrombotic thrombocytopenic purpura (TTP)
  39. tinnitus
  40. toxic epidermal necrolysis
  41. urticaria
  42. vaginitis
  43. vertigo
  44. vomiting

Monitoring Parameters

  • CBC
  • LFTs
  • serum creatinine/BUN

Contraindications

  • asthma
  • atopy
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • clindamycin hypersensitivity
  • colitis
  • diarrhea
  • fungal infection
  • hepatic disease
  • infants
  • inflammatory bowel disease
  • lincomycin hypersensitivity
  • neonates
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atracurium
  • Belladonna; Opium
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cisatracurium
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Cyclosporine
  • Dienogest; Estradiol valerate
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doxacurium
  • Enflurane
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Fentanyl
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Isoflurane
  • Levorphanol
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Mivacurium
  • Morphine
  • Morphine; Naltrexone
  • Neuromuscular blockers
  • Opiate Agonists
  • Oral Contraceptives
  • Oxycodone
  • Oxymorphone
  • Pancuronium
  • Propoxyphene
  • Rapacuronium
  • Remifentanil
  • Rocuronium
  • Sevoflurane
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Succinylcholine
  • Sufentanil
  • Tubocurarine
  • Vecuronium
  • Vitamin C
  • Warfarin
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