Lindane

Lindane Brand Names- G B H | GBH | Lindane

What is Lindane

Lindane is a topical scabicide.

Lindane is the gamma isomer of hexachlorocyclohexane (also known as BHC), a potent insecticide. Lindane is used as an ectoparasitacide in the treatment of scabies and pediculosis.

Lindane is toxic to Sarcoptes scabiei (scabies) and its eggs; to Pediculus capitis (head louse), Pediculus corporis (body louse), and Pthirus pubis (crab louse) and possibly to their nits.

Lindane is a prescription-only agent and was approved by the FDA in 1947. The toxicities of lindane, particularly neurotoxicity, have been well described in the medical literature.

Consistent with previous FDA recommendations from 1996, the FDA approved a Black Box warning labeling change for lindane products in March 2003.

The new label reinforces that lindane only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of lice or scabies.

The warning pertains to the fact that seizures and deaths have been reported following lindane use with repeat or prolonged application, but also in rare cases following a single application according to directions.

Certain individuals are more likely to be at risk for serious neurotoxicity (see Contraindications/Precautions).

Patients must be given an official Medication Guide regarding the proper use of lindane products and must be instructed regarding the amount to apply and how long to leave the product on, as well as avoiding retreatment.

Indications

  1. pediculosis
  2. Pediculus capitis
  3. Phthirus pubis
  4. Sarcoptes scabiei
  5. scabies

Side Effects

  1. alopecia
  2. contact dermatitis
  3. dizziness
  4. headache
  5. nausea
  6. neurotoxicity
  7. paresthesias
  8. pruritus
  9. rash
  10. restlessness
  11. seizures
  12. skin irritation
  13. urticaria
  14. vomiting
  15. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • alcoholism
  • atopy
  • brain tumor
  • breast-feeding
  • burns
  • children
  • crusted (Norwegian) scabies
  • eczema
  • exfoliative dermatitis
  • geriatric
  • head trauma
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • infants
  • inflammation
  • neonates
  • neurotoxicity
  • occlusive dressing
  • ocular exposure
  • pregnancy
  • premature neonates
  • psoriasis
  • seizure disorder
  • seizures
  • skin abrasion
  • skin disease

Interactions

There are no drug interactions associated with Lindane products.

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