Lemborexant Brand Name– DAYVIGO
What is Lemborexant
Lemborexant is an oral orexin receptor antagonist indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance in adults.
Lemborexant alters the signaling of neurotransmitters called orexins, which are responsible for regulating the sleep-wake cycle.
Similar to other hypnotics, lemborexant may cause worsening of depression or suicidality, primarily in patients with pre-existing depression. In addition, complex sleep-related behaviors such as sleep-walking, sleep talking, or engagement in other activities while not fully awake are also possible.
Patients should be informed of the potential for worsening depression, suicidality, or complex sleep-related behaviors prior to initiating treatment with lemborexant and be advised to seek medical attention immediately if any of these adverse effects occur during treatment with lemborexant.
Indications
- insomnia
For the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance
Side Effects
- abnormal dreams
- complex sleep-related behaviors
- depression
- drowsiness
- fatigue
- hallucinations
- headache
- memory impairment
- nightmares
- psychological dependence
- sleep paralysis
- suicidal ideation
- weakness
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- alcoholism
- behavioral changes
- breast-feeding
- chronic obstructive pulmonary disease (COPD)
- coadministration with other CNS depressants
- complex sleep-related behaviors
- depression
- driving or operating machinery
- ethanol ingestion
- geriatric
- hepatic disease
- labor
- narcolepsy
- obstetric delivery
- pregnancy
- pulmonary disease
- sleep apnea
- sleep paralysis
- substance abuse
- suicidal ideation
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anxiolytics; Sedatives; and Hypnotics
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Bexarotene
- Bicalutamide
- Bosentan
- Brexpiprazole
- Brigatinib
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clemastine
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Crizotinib
- Cyclizine
- Cyclobenzaprine
- Cyclosporine
- Cyproheptadine
- Dabrafenib
- Dalfopristin; Quinupristin
- Danazol
- Dantrolene
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Entacapone
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Estazolam
- Ethanol
- Etomidate
- Etravirine
- Everolimus
- Fedratinib
- Fenfluramine
- Fentanyl
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Fostamatinib
- Gabapentin
- General anesthetics
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Istradefylline
- Itraconazole
- Ivacaftor
- Ketamine
- Ketoconazole
- Lanreotide
- Lapatinib
- Larotrectinib
- Lasmiditan
- Lefamulin
- Letermovir
- Levocetirizine
- Levodopa
- Levorphanol
- Lofexidine
- Lopinavir; Ritonavir
- Lorazepam
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mesoridazine
- Metaxalone
- Methadone
- Methocarbamol
- Methohexital
- Methyldopa
- Metoclopramide
- Midazolam
- Mifepristone
- Mirtazapine
- Mitotane
- Modafinil
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nafcillin
- Nalbuphine
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nortriptyline
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Opiate Agonists-Antagonists
- Orphenadrine
- Osilodrostat
- Oxazepam
- Oxycodone
- Oxymorphone
- Palbociclib
- Paliperidone
- Pazopanib
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Phenytoin
- Posaconazole
- Pramipexole
- Pregabalin
- Primidone
- Prochlorperazine
- Promethazine
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Quinine
- Ramelteon
- Ranitidine
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Risperidone
- Ritonavir
- Ropinirole
- Rotigotine
- Rucaparib
- Safinamide
- Saquinavir
- Scopolamine
- Secobarbital
- Sedating H1-blockers
- Selegiline
- Selpercatinib
- Sevoflurane
- Simeprevir
- Sodium Oxybate
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Suvorexant
- Tapentadol
- Tasimelteon
- Telithromycin
- Temazepam
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiethylperazine
- Thioridazine
- Ticagrelor
- Tipranavir
- Tizanidine
- Tolcapone
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Triazolam
- Tricyclic antidepressants
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- Trimipramine
- Triprolidine
- Tucatinib
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Verapamil
- Voriconazole
- Voxelotor
- Zafirlukast
- Ziprasidone