Isoniazid Brand Name– Nydrazid
What is Isoniazid (INH)
Isoniazid (INH) is used in the treatment of mycobacterial disease.
Isoniazid is chemically related to iproniazid, a drug that was used in the early 1950s for the treatment of tuberculosis but also possessed some monoamine oxidase inhibiting properties.
Due to its efficacy and low cost, INH is considered a first-line agent in the treatment of susceptible M. tuberculosis organisms.
INH appears to be more effective and less toxic than other antitubercular agents including aminosalicylic acid, capreomycin, cycloserine, ethionamide, and kanamycin.
Isoniazid was approved by the FDA in 1952.
Indications
- Mycobacterium avium
- Mycobacterium bovis
- Mycobacterium intracellulare
- Mycobacterium kansasii
- Mycobacterium sp.
- Mycobacterium szulgai
- Mycobacterium tuberculosis
- Mycobacterium xenopi
- tuberculosis infection
- tuberculosis prophylaxis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- angioedema
- aplastic anemia
- bronchospasm
- chest pain (unspecified)
- chills
- conjunctivitis
- cough
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- exfoliative dermatitis
- fever
- gynecomastia
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- hypotension
- injection site reaction
- interstitial nephritis
- jaundice
- lupus-like symptoms
- lymphadenopathy
- maculopapular rash
- memory impairment
- metabolic acidosis
- myalgia
- nausea
- neutropenia
- optic neuritis
- palpitations
- pancreatitis
- paresthesias
- peripheral neuropathy
- psychosis
- purpura
- rash
- seizures
- sideroblastic anemia
- skin irritation
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vitamin B6 deficiency
- vitamin D deficiency
- vomiting
Monitoring Parameters
- LFTs
- ophthalmologic exam
Contraindications
- acne vulgaris
- alcoholism
- Black patients
- breast-feeding
- diabetes mellitus
- females
- geriatric
- hepatic disease
- hepatitis
- hepatotoxicity
- Hispanic patients
- human immunodeficiency virus (HIV) infection
- jaundice
- malnutrition
- MAOI therapy
- peripheral neuropathy
- pregnancy
- renal failure
- renal impairment
- seizure disorder
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aldesleukin, IL-2
- Alfentanil
- Alosetron
- Alprazolam
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bacillus Calmette-Guerin Vaccine, BCG
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Caffeine
- Caffeine; Ergotamine
- Cannabidiol
- Capreomycin
- Carbamazepine
- Carbidopa
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cisapride
- Citalopram
- Clobazam
- Clomipramine
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Cycloserine
- Cyclosporine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Desipramine
- Desvenlafaxine
- Diazepam
- Dichlorphenamide
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Disulfiram
- Dofetilide
- Doxepin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Duloxetine
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Ethambutol
- Ethanol
- Ethionamide
- Fedratinib
- Fentanyl
- Flibanserin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- food
- Fosphenytoin
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Imipramine
- Indinavir
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ixabepilone
- Ketoconazole
- Leflunomide
- Lemborexant
- Levodopa
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Lomitapide
- Mefloquine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylprednisolone
- Midazolam
- Milnacipran
- Mirtazapine
- Nisoldipine
- Nortriptyline
- Omeprazole; Amoxicillin; Rifabutin
- Oxycodone
- Paroxetine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenelzine
- Phenytoin
- Procarbazine
- Protriptyline
- Pyrazinamide, PZA
- Rasagiline
- Rifabutin
- Rifampin
- Rifapentine
- Riluzole
- Safinamide
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sertraline
- Sevoflurane
- Sibutramine
- Sufentanil
- Tacrolimus
- Tedizolid
- Theophylline, Aminophylline
- Tramadol
- Tranylcypromine
- Trimipramine
- Ubrogepant
- Valproic Acid, Divalproex Sodium
- Venlafaxine
- Vilazodone
- Vinorelbine
- Voriconazole
- Vortioxetine
- Warfarin
- Zalcitabine, ddC