Isoniazid INH

Isoniazid Brand Name– Nydrazid

What is Isoniazid (INH)

Isoniazid (INH) is used in the treatment of mycobacterial disease.

Isoniazid is chemically related to iproniazid, a drug that was used in the early 1950s for the treatment of tuberculosis but also possessed some monoamine oxidase inhibiting properties.

Due to its efficacy and low cost, INH is considered a first-line agent in the treatment of susceptible M. tuberculosis organisms.

INH appears to be more effective and less toxic than other antitubercular agents including aminosalicylic acid, capreomycin, cycloserine, ethionamide, and kanamycin.

Isoniazid was approved by the FDA in 1952.

Indications

  1. Mycobacterium avium
  2. Mycobacterium bovis
  3. Mycobacterium intracellulare
  4. Mycobacterium kansasii
  5. Mycobacterium sp.
  6. Mycobacterium szulgai
  7. Mycobacterium tuberculosis
  8. Mycobacterium xenopi
  9. tuberculosis infection
  10. tuberculosis prophylaxis

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. angioedema
  5. aplastic anemia
  6. bronchospasm
  7. chest pain (unspecified)
  8. chills
  9. conjunctivitis
  10. cough
  11. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  12. dyspnea
  13. elevated hepatic enzymes
  14. encephalopathy
  15. eosinophilia
  16. exfoliative dermatitis
  17. fever
  18. gynecomastia
  19. hemolytic anemia
  20. hepatitis
  21. hyperbilirubinemia
  22. hyperglycemia
  23. hypotension
  24. injection site reaction
  25. interstitial nephritis
  26. jaundice
  27. lupus-like symptoms
  28. lymphadenopathy
  29. maculopapular rash
  30. memory impairment
  31. metabolic acidosis
  32. myalgia
  33. nausea
  34. neutropenia
  35. optic neuritis
  36. palpitations
  37. pancreatitis
  38. paresthesias
  39. peripheral neuropathy
  40. psychosis
  41. purpura
  42. rash
  43. seizures
  44. sideroblastic anemia
  45. skin irritation
  46. Stevens-Johnson syndrome
  47. syncope
  48. thrombocytopenia
  49. toxic epidermal necrolysis
  50. urticaria
  51. vasculitis
  52. vitamin B6 deficiency
  53. vitamin D deficiency
  54. vomiting

Monitoring Parameters

  • LFTs
  • ophthalmologic exam

Contraindications

  • acne vulgaris
  • alcoholism
  • Black patients
  • breast-feeding
  • diabetes mellitus
  • females
  • geriatric
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • Hispanic patients
  • human immunodeficiency virus (HIV) infection
  • jaundice
  • malnutrition
  • MAOI therapy
  • peripheral neuropathy
  • pregnancy
  • renal failure
  • renal impairment
  • seizure disorder

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aldesleukin, IL-2
  • Alfentanil
  • Alosetron
  • Alprazolam
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine; Lidocaine
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Cannabidiol
  • Capreomycin
  • Carbamazepine
  • Carbidopa
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cilostazol
  • Cisapride
  • Citalopram
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Cycloserine
  • Cyclosporine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Desipramine
  • Desvenlafaxine
  • Diazepam
  • Dichlorphenamide
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Dofetilide
  • Doxepin
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Duloxetine
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enflurane
  • Escitalopram
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Ethambutol
  • Ethanol
  • Ethionamide
  • Fedratinib
  • Fentanyl
  • Flibanserin
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • food
  • Fosphenytoin
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Imipramine
  • Indinavir
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ixabepilone
  • Ketoconazole
  • Leflunomide
  • Lemborexant
  • Levodopa
  • Levomilnacipran
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linezolid
  • Lomitapide
  • Mefloquine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methylene Blue
  • Methylprednisolone
  • Midazolam
  • Milnacipran
  • Mirtazapine
  • Nisoldipine
  • Nortriptyline
  • Omeprazole; Amoxicillin; Rifabutin
  • Oxycodone
  • Paroxetine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenelzine
  • Phenytoin
  • Procarbazine
  • Protriptyline
  • Pyrazinamide, PZA
  • Rasagiline
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Riluzole
  • Safinamide
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sufentanil
  • Tacrolimus
  • Tedizolid
  • Theophylline, Aminophylline
  • Tramadol
  • Tranylcypromine
  • Trimipramine
  • Ubrogepant
  • Valproic Acid, Divalproex Sodium
  • Venlafaxine
  • Vilazodone
  • Vinorelbine
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Zalcitabine, ddC
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