Iodine Potassium Iodide KI Brand Name– Lugols
What is Iodine Potassium Iodide KI
Iodine Potassium Iodide KI is most commonly known as Lugol’s solution.
It is a strong iodine solution containing 5% iodine and at least 10% potassium iodide.
The oral solution is used as adjunctive therapy for hyperthyroidism, to reduce thyroid gland vascularity, prior to thyroidectomy.
Iodides help induce a euthyroid state, facilitating surgery and decreasing postoperative complications. Iodine; potassium iodide can also be used for thyrotoxicosis in conjunction with supportive measures to control fever and adequate fluid intake.
It is not intended for long term treatment of hyperthyroidism as, after a variable period of time, the beneficial effects wear off and the condition may return in its initial intensity or become more severe.
Optimal control of hyperthyroidism prior to thyroidectomy is usually achieved if therapy is initiated with an antithyroid drug and then iodine; potassium iodide is added on as an adjunct, though iodine; potassium iodide could potentially be used alone.
The topical formulation is used as an antiseptic for its’ antimicrobial and antifungal properties.
Iodine potassium iodide KI has been marketed since 1940, prior to when Congress passed the 1962 amended Federal Food, Drug, and Cosmetic Act, requiring that the FDA establish both safety and efficacy for all approved drugs.
Indications
- hyperthyroidism
- skin antisepsis
- thyroid involution induction
- thyrotoxicosis
For the treatment of hyperthyroidism, as well as for thyroid involution induction, prior to thyroidectomy
Side Effects
- abdominal pain
- diarrhea
- metallic taste
- nausea
- rash
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- breast-feeding
- iodine hypersensitivity
- ophthalmic administration
- pregnancy
- tuberculosis
Interactions
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Ammonium Chloride
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Celecoxib
- Chlordiazepoxide; Clidinium
- Ciclesonide
- Corticosteroids
- Cortisone
- Cyclosporine
- Deflazacort
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Dicyclomine
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flavoxate
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Heparin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indacaterol; Glycopyrrolate
- Indomethacin
- Iodoquinol
- Irbesartan
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lisinopril
- Lithium
- Loperamide
- Loperamide; Simethicone
- Losartan
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mepenzolate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methimazole
- Methscopolamine
- Methylprednisolone
- Moexipril
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol; Valsartan
- Nonsteroidal antiinflammatory drugs
- Olmesartan
- Oxaprozin
- Oxybutynin
- Penicillin G
- Perindopril
- Perindopril; Amlodipine
- Piroxicam
- Prednisolone
- Prednisone
- Propantheline
- Propylthiouracil, PTU
- Quinapril
- Ramipril
- Rofecoxib
- Sacubitril; Valsartan
- Scopolamine
- Sodium Iodide
- Sodium Polystyrene Sulfonate
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulindac
- Tacrolimus
- Telmisartan
- Thyroid hormones
- Tolmetin
- Trandolapril
- Trandolapril; Verapamil
- Triamcinolone
- Triamterene
- Trihexyphenidyl
- Trimethoprim
- Valdecoxib
- Valsartan
