Sodium Iodide

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What is Sodium Iodide

Sodium iodide is a nutritional supplement for addition to total parenteral nutrition (TPN) solutions. It is primarily indicated to prevent depletion of endogenous iodine stores and related iodine deficiency symptoms.

Iodide is the ionized form of iodine, an essential trace element for humans and an integral part of the thyroid hormones, triiodothyronine (T3) and thyroxine (T4). Iodine was first discovered in 1811 and was noted to sublimate into a violet vapor when heated.

Because of this, the element is named after the Greek word for violet, ‘iodes’. Deficiency of iodine results in histological changes in thyroid gland and impaired thyroid function, which may cause goiter. Iodine deficiency in early stages of life has been reported to produce cretinism.

To combat iodine deficiency and goiter, the United States begin iodizing salt in the 1920s. The typical diet supplies greater than twice the recommended daily amount of 150 mcg. Other dietary sources of iodide include seaweed (kelp, dulse, or sea lettuce), shellfish (clams, oysters, shrimp), and marine fish.

Sodium iodide is also present in some multivitamin and mineral combination products.

Goitrogens, which interfere with thyroid metabolism, are also present in the typical diet and include nitrates, broccoli, cabbage, brussel sprouts, cassava, and rutabagas.

Brand Name

Iodopen

Indications & Dosage

  • nutritional supplementation

For use as nutritional supplementation in total parenteral nutrition (TPN)

Side Effects

  1. acneiform rash
  2. angioedema
  3. blepharitis
  4. eosinophilia
  5. headache
  6. hypersalivation
  7. iodine toxicity
  8. iododerma
  9. lymphadenopathy
  10. metallic taste
  11. pulmonary edema
  12. sneezing

Monitoring Parameters

  • thyroid function tests (TFTs)

Contraindications

  • breast-feeding
  • goiter
  • intravenous administration
  • iodine hypersensitivity
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • vasculitis

Interactions

  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acrivastine; Pseudoephedrine
  • Anticoagulants
  • Antithrombin III
  • Apixaban
  • Argatroban
  • Betrixaban
  • Bivalirudin
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clemastine
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Edoxaban
  • Enoxaparin
  • Erythromycin; Sulfisoxazole
  • Estradiol; Progesterone
  • Fondaparinux
  • Heparin
  • Hydroxyzine
  • Iodine; Potassium Iodide, KI
  • Iohexol
  • Ionic Contrast Media
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isosulfan Blue
  • Lepirudin
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Liothyronine
  • Lithium
  • Meclizine
  • Methimazole
  • Non-Ionic Contrast Media
  • Pentosan
  • Potassium Iodide, KI
  • Prednisone
  • Progesterone
  • Propylthiouracil, PTU
  • Pyrimethamine; Sulfadoxine
  • Rivaroxaban
  • Sedating H1-blockers
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Thyroid hormones
  • Tinzaparin
  • Tolbutamide
  • Triprolidine
  • Warfarin

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