Sodium Iodide I 131

What is Sodium Iodide I 131

Sodium iodide I-131 (Na131I), is an oral radioactive iodide isotope that is used both therapeutically and diagnostically. The radiopharmaceutical is selectively trapped by non-malignant and, to a lesser degree, malignant thyroid tissue.

Sodium iodide I-131 was approved in 1957 for radioactive iodide ablation in the treatment of hyperthyroidism and select cases of thyroid carcinoma. Radioiodide is not taken up by the majority of medullary and anaplastic carcinomas including giant cell and spindle cell carcinoma of the thyroid or amyloid solid carcinomas.

When used therapeutically, the preferred formulation and dosing regimen is highly physician specific.

Sodium iodide I-131 was also approved as a diagnostic aid in December 2005; the gamma and beta particle emissions are used to evaluate thyroid function via the radioactive iodine (RAI) uptake test and for thyroid imaging.

Indications & Dosage

  • goiter
  • Graves’ disease
  • hyperthyroidism
  • thyroid cancer
  • thyroid function diagnosis

Side Effects

  1. alopecia
  2. anaphylactoid reactions
  3. anemia
  4. bronchospasm
  5. cerebral edema
  6. chest pain (unspecified)
  7. conjunctivitis
  8. cough
  9. diarrhea
  10. dysgeusia
  11. elevated hepatic enzymes
  12. epiphora
  13. erythema
  14. gastritis
  15. hyperthyroidism
  16. hypothyroidism
  17. infertility
  18. iododerma
  19. leukopenia
  20. nausea
  21. new primary malignancy
  22. pneumonitis
  23. pruritus
  24. pulmonary fibrosis
  25. rash
  26. sialadenitis
  27. sinus tachycardia
  28. throat irritation
  29. thrombocytopenia
  30. thyroid adenoma
  31. thyrotoxicosis
  32. vomiting
  33. xerophthalmia
  34. xerostomia

Monitoring Parameters

  • CBC
  • platelet count
  • pregnancy testing
  • red blood cell count (RBC)
  • serum chloride
  • serum creatinine/BUN
  • thyroid function tests (TFTs)

Contraindications

  • accidental exposure
  • anticholinergic medications
  • asthma
  • bone marrow suppression
  • breast-feeding
  • cardiac disease
  • children
  • contraception requirements
  • dehydration
  • diarrhea
  • geriatric
  • hyperthyroidism
  • hypochloremia
  • infants
  • infertility
  • iodine hypersensitivity
  • leukopenia
  • medullary thyroid carcinoma (MTC)
  • neonates
  • neoplastic disease
  • neutropenia
  • ovarian failure
  • potential for overdose or poisoning
  • pregnancy
  • pregnancy testing
  • radiographic contrast administration
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk
  • sulfite hypersensitivity
  • thrombocytopenia
  • vomiting

Interactions

No information is available regarding drug interactions associated with Sodium Iodide I-131 

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top