Iodipamide Meglumine Brand Name– Cholografin Meglumine
What is Iodipamide Meglumine
Iodipamide meglumine is an iodinated, ionic radiographic contrast agent indicated for intravenous cholangiography and cholecystography.
Iodipamide meglumine is only approved for intravenous administration; avoid inadvertent intrathecal administration as this can result in serious adverse events, including death.
Serious and potentially fatal adverse events (i.e., hypersensitivity reactions, severe cutaneous adverse reactions, acute renal failure) may also occur during intravascular use.
To minimize the toxicity risk, ensure the patients are adequately hydrated.
Indications
- hepatobiliary system dysfunction diagnosis
NOTE: Patients should be well hydrated prior to and following iodipamide meglumine administration. A suggested common regimen in eligible patients (e.g., those patients in which fluid administration would not be contraindicated) is 1 mL/kg/hour of 0.9% Sodium Chloride Injection starting at least 4 hours prior to the procedure or exam and continuing for at least 12 hours after.
NOTE: In patients with a history of allergic reaction to contrast media or iodine, those with a history of asthma or allergic reactions to drugs or foods, nonionic contrast media should be used. In addition, consider administering prednisone 50 mg PO (or equivalent dose of other steroids) 13 hours, 7 hours, and 1 hour prior to the exam or procedure plus diphenhydramine 50 mg IM or PO 1 hour prior to the procedure.
The administration of prophylactic steroids and antihistamines does not prevent all hypersensitivity reactions, but reduces the likelihood and may decrease the severity of the reaction.
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- anaphylactoid reactions
- angioedema
- arachnoiditis
- bronchospasm
- cardiac arrest
- cerebral edema
- chills
- coma
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- erythema
- fever
- flushing
- headache
- hypersalivation
- hyperthermia
- hyperthyroidism
- hypotension
- hypothyroidism
- laryngospasm
- maculopapular rash
- nasal congestion
- nausea
- nephrotoxicity
- pallor
- pruritus
- rash
- restlessness
- rhabdomyolysis
- seizures
- skin discoloration
- Stevens-Johnson syndrome
- stroke
- thyrotoxicosis
- toxic epidermal necrolysis
- tremor
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- atopy
- breast-feeding
- coagulopathy
- dehydration
- diabetes mellitus
- emphysema
- extravasation
- females
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypothyroidism
- infants
- intrathecal administration
- iodine hypersensitivity
- laboratory test interference
- multiple myeloma
- neonates
- pheochromocytoma
- pregnancy
- premature neonates
- pulmonary disease
- radiation exposure
- radiopaque contrast media hypersensitivity
- renal disease
- renal failure
- renal impairment
- serious rash
- sickle cell disease
- thromboembolic disease
- thyroid disease
- thyrotoxicosis
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acyclovir
- Aldesleukin, IL-2
- Alogliptin; Metformin
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Canagliflozin; Metformin
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Codeine; Phenylephrine; Promethazine
- Dapagliflozin; Metformin
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dopamine
- Droxidopa
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Ephedrine
- Ertugliflozin; Metformin
- Ethanol
- Etomidate
- Fospropofol
- General anesthetics
- Glipizide; Metformin
- Glyburide; Metformin
- Guaifenesin; Phenylephrine
- Halothane
- Hydrocodone; Phenylephrine
- Isoflurane
- Ketamine
- Linagliptin; Metformin
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Midodrine
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Oxaliplatin
- Phenylephrine
- Phenylephrine; Promethazine
- Propofol
- Sevoflurane
- Sodium Iodide
- Valacyclovir
- Vasopressors