Iobenguane I 131 Brand Name– Azedra
What is Iobenguane I 131
Iobenguane I 131 is a radioactive therapeutic agent indicated for the treatment of iobenguane scan-positive unresectable, locally advanced, or metastatic pheochromocytoma or paraganglioma in patients aged 12 years and older who require systemic anticancer therapy.
Myelosuppression and renal toxicity have been reported; monitoring of complete blood counts and renal function is recommended.
Indications
- paraganglioma
- pheochromocytoma
For the treatment of iobenguane scan-positive unresectable, locally advanced, or metastatic pheochromocytoma or paraganglioma in patients who require systemic anticancer therapy
NOTE: Iobenguane I-131 has been designated an orphan drug by the FDA for the treatment of neuroendocrine tumors.
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- candidiasis
- chest pain (unspecified)
- chills
- constipation
- constipation
- cough
- dehydration
- dehydration
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- fatigue
- fatigue
- fever
- fever
- gastroesophageal reflux
- headache
- headache
- hyperhidrosis
- hypertension
- hypertension
- hypotension
- hypotension
- hypothyroidism
- infection
- infection
- injection site reaction
- insomnia
- leukemia
- lymphopenia
- lymphopenia
- muscle cramps
- nasal congestion
- nausea
- nausea
- nephrotoxicity
- neutropenia
- neutropenia
- new primary malignancy
- orthostatic hypotension
- palpitations
- petechiae
- pharyngitis
- pharyngitis
- pneumonitis
- prolonged bleeding time
- proteinuria
- pulmonary embolism
- rash
- renal failure (unspecified)
- rhinorrhea
- rhinorrhea
- sialadenitis
- sialadenitis
- sinus tachycardia
- sinus tachycardia
- sinusitis
- sinusitis
- stomatitis
- syncope
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- weight loss
- weight loss
- xerosis
- xerostomia
- xerostomia
Monitoring Parameters
- blood pressure
- CBC with differential
- pregnancy testing
- serum creatinine/BUN
- thyroid function tests (TFTs)
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- children
- contraception requirements
- hypertension
- hypothyroidism
- infertility
- male-mediated teratogenicity
- neutropenia
- new primary malignancy
- pneumonitis
- pregnancy
- pregnancy testing
- renal disease
- renal impairment
- reproductive risk
- requires an experienced clinician
- thrombocytopenia
- thyroid disease
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amphetamine
- Amphetamine; Dextroamphetamine
- Articaine; Epinephrine
- Atomoxetine
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupropion
- Bupropion; Naltrexone
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clomipramine
- Codeine; Phenylephrine; Promethazine
- Desipramine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Doxepin
- Duloxetine
- Ephedrine
- Epinephrine
- Fexofenadine; Pseudoephedrine
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Imipramine
- Isocarboxazid
- Isoproterenol
- Labetalol
- Levomilnacipran
- Linezolid
- Lisdexamfetamine
- Loratadine; Pseudoephedrine
- Maprotiline
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methylphenidate
- Midodrine
- Milnacipran
- Mirtazapine
- Monoamine oxidase inhibitors
- Nadolol
- Naproxen; Pseudoephedrine
- Norepinephrine
- Nortriptyline
- Palifermin
- Pemoline
- Penbutolol
- Penicillamine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Prilocaine; Epinephrine
- Propranolol
- Protriptyline
- Pseudoephedrine
- Racepinephrine
- Reserpine
- Ritodrine
- Selective norepinephrine reuptake inhibitors
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- St. John’s Wort, Hypericum perforatum
- Sympathomimetics
- Timolol
- Tramadol
- Tranylcypromine
- Tricyclic antidepressants
- Trimipramine
- Tuberculin Purified Protein Derivative, PPD
- Venlafaxine
- Yohimbine