Guaifenesin Potassium Guaiacolsulfonate

Guaifenesin Potassium Guaiacolsulfonate Brand Names- AllFen | Humibid LA

What is Guaifenesin Potassium Guaiacolsulfonate

NOTE: These products have been discontinued in the U.S.

Guaifenesin and potassium guaiacolsulfonate are historically used together as oral expectorants.

Despite its long history of use since the 1950’s, the efficacy of guaifenesin has only recently been substantiated.

The results of a few studies have favored active treatment with guaifenesin over placebo in treating productive cough due to upper respiratory illness (URI).

In patients with chronic bronchitis, guaifenesin, is not recommended for aiding with cough suppression since studies have shown no benefit in reducing cough.

However, the mucolytic properties of guaifenesin may be independently helpful in clearing mucus, and patients may subjectively report benefit to use.

An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.

New regulatory guidelines regarding expectorants were issued by the FDA in October 2003.

Some cough products were reformulated to contain guaifenesin and potassium guaiacolsulfonate in an extended-release formulation; however, in April 2004, manufacturers of these combinations received letters from the FDA indicating that these reformulated products were sold in violation of existing drug regulations; the FDA considers these combinations to be new drugs that require proper FDA regulatory approval prior to marketing.

Indications

  • cough

For the temporary relief of cough complicated by tenacious mucus and/or mucus plugs and congestion, such as may occur with the common cold

Side Effects

  1. abdominal pain
  2. diarrhea
  3. dizziness
  4. headache
  5. nausea
  6. nephrolithiasis
  7. rash
  8. urticaria
  9. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • breast-feeding
  • bronchitis
  • children
  • emphysema
  • fever
  • geriatric
  • headache
  • infants
  • neonates
  • pregnancy
  • tobacco smoking
  • vomiting

Interactions

  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Celecoxib
  • Chlordiazepoxide; Clidinium
  • Ciclesonide
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Deflazacort
  • Dexamethasone
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicyclomine
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Flavoxate
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Heparin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Irbesartan
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lisinopril
  • Loperamide
  • Loperamide; Simethicone
  • Losartan
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Mepenzolate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methylprednisolone
  • Moexipril
  • Mometasone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Olmesartan
  • Oxaprozin
  • Oxybutynin
  • Penicillin G
  • Perindopril
  • Perindopril; Amlodipine
  • Piroxicam
  • Prednisolone
  • Prednisone
  • Propantheline
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Sacubitril; Valsartan
  • Scopolamine
  • Sodium Polystyrene Sulfonate
  • Spironolactone
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulindac
  • Tacrolimus
  • Telmisartan
  • Tolmetin
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triamterene
  • Trihexyphenidyl
  • Trimethoprim
  • Valdecoxib
  • Valsartan
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