Hydrocodone Pseudoephedrine

Hydrocodone Pseudoephedrine Brand Names

ColdCough HCM | Detussin | H Tuss D | HC Tussive D | Histussin D | Hytussin | Iotussin D | P V Tussin | Pancof HC | Rezira | SymTan | Tuss S

What is Hydrocodone Pseudoephedrine

Hydrocodone and pseudoephedrine are used together in an oral preparation to relieve cough and congestion. This combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, influenza, sinusitis, or bronchitis.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Pseudoephedrine is a sympathomimetic decongestant agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.

This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Opioid cough and cold medicines that contain hydrocodone are contraindicated in pediatric patients; risks of these medicines outweigh their benefits in patients younger than 18 years.

Indications

  • common cold
  • cough
  • nasal congestion

For the treatment of cough and nasal congestion due to the common cold

Side Effects

  1. angina
  2. anxiety
  3. arrhythmia exacerbation
  4. blurred vision
  5. confusion
  6. constipation
  7. dizziness
  8. drowsiness
  9. dysphoria
  10. dysuria
  11. emotional lability
  12. euphoria
  13. headache
  14. hypotension
  15. impaired cognition
  16. insomnia
  17. lethargy
  18. myocardial infarction
  19. nausea
  20. palpitations
  21. photophobia
  22. premature ventricular contractions (PVCs)
  23. pruritus
  24. psychological dependence
  25. rash
  26. respiratory depression
  27. sinus tachycardia
  28. stroke
  29. supraventricular tachycardia (SVT)
  30. tolerance
  31. urinary retention
  32. urticaria
  33. vomiting
  34. weakness
  35. withdrawal
  36. xerophthalmia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acute abdomen
  • acute myocardial infarction
  • adrenal insufficiency
  • angina
  • anticholinergic medications
  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • coadministration with other CNS depressants
  • constipation
  • coronary artery disease
  • diabetes mellitus
  • diarrhea
  • driving or operating machinery
  • emphysema
  • ethanol ingestion
  • geriatric
  • GI obstruction
  • head trauma
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • labor
  • MAOI therapy
  • neonatal opioid withdrawal syndrome
  • neonates
  • obstetric delivery
  • opiate agonist hypersensitivity
  • pregnancy
  • prostatic hypertrophy
  • renal impairment
  • respiratory depression
  • substance abuse
  • ulcerative colitis
  • urethral stricture
  • urinary retention
  • ventricular tachycardia

Interactions

  • Abiraterone
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren; Amlodipine
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  • Aliskiren; Hydrochlorothiazide, HCTZ
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  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
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  • Carbetapentane; Pyrilamine
  • Carbinoxamine
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  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
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  • Castor Oil
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  • Chloral Hydrate
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  • Chlordiazepoxide; Clidinium
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  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clemastine
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  • grapefruit juice
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  • Selexipag
  • Selpercatinib
  • Semaglutide
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sorbitol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Suvorexant
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Tedizolid
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Ticagrelor
  • Timolol
  • Tizanidine
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Triprolidine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vasodilators
  • Vasopressors
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem