Hydrocortisone

Hydrocortisone Brand Names

A-Hydrocort | Ala-Cort | Ala-Scalp | Anucort-HC | Anumed-HC | Anusol HC | Balneol for Her | Caldecort | Cetacort | Colocort | Cortaid | Cortaid Advanced | Cortaid Intensive Therapy | Cortaid Sensitive Skin | CortAlo | Cortef | Cortenema | Corticaine | Corticool | Cortifoam | Cortizone | Cortizone-10 | Cortizone-10 Cooling Relief | Cortizone-10 Intensive Healing | Cortizone-10 Plus | Dermarest Dricort | Dermarest Eczema | Dermarest Itch Relief | Encort | First – Hydrocortisone | Gly-Cort | GRx HiCort | Hemmorex-HC | Hemorrhoidal-HC | Hemril | Hycort | Hydro Skin | Hydrocortisone in Absorbase | Hydrocortone | Hydroskin | Hytone | Instacort | Lacticare HC | Locoid | Locoid Lipocream | MiCort-HC | Monistat Complete Care Instant Itch Relief Cream | Neosporin Eczema | NuCort | Nutracort | NuZon | Pandel | Penecort | Preparation H Hydrocortisone | Proctocort | Proctocream-HC | Procto-Kit | Procto-Med HC | Procto-Pak | Proctosert HC | Proctosol-HC | Proctozone-HC | Rectacort HC | Rectasol-HC | Rederm | Sarnol-HC | Scalacort | Scalpicin Anti-Itch | Solu-Cortef | Texacort | Tucks HC | Vagisil Anti-Itch | Walgreens Intensive Healing | Westcort

What is Hydrocortisone

Hydrocortisone is a naturally-occurring steroid hormone secreted by the adrenal cortex that has glucocorticoid and mineralocorticoid activity. Synthetic hydrocortisone is available pharmaceutically in a variety of rectal, parenteral, oral, and topical dosage forms.

As a naturally occurring glucocorticoid that also has salt-retaining properties systemic hydrocortisone is used primarily as replacement therapy in adrenocortical deficiency states, and when emergency anti-inflammatory treatment is needed.

Rectal hydrocortisone products are particularly useful in inflammatory gastrointestinal conditions limited to the rectum and anus.

Systemic hydrocortisone may be used in many other allergic, immune, and inflammatory conditions in adult and pediatric patients; however, systemic corticosteroids that have more potent glucocorticoid activity and minimal mineralocorticoid activity, such as prednisone, are preferred for such uses, as they induce better response and reduce the risks of excess mineralocorticoid side effects.

Systemic corticosteroids may be added to other long-term maintenance medications in the management of uncontrolled severe persistent asthma and short courses may be used for asthma exacerbations; however, systemic hydrocortisone is rarely used for these purposes.

Topical hydrocortisone is considered low potency and is used in mild to moderate corticosteroid-responsive dermatoses, and many topical dosage forms are available without a prescription.

Low potency topical corticosteroids are the safest for chronic use and may be used on the face or intertriginous areas, with occlusion, and in infants and young children.

Indications

  1. acute lymphocytic leukemia (ALL)
  2. Addison’s disease
  3. adrenocortical insufficiency
  4. allergic conjunctivitis
  5. allergic rhinitis
  6. alopecia
  7. anaphylactic shock
  8. anaphylaxis
  9. angioedema
  10. ankylosing spondylitis
  11. anterior segment inflammation
  12. asthma
  13. atopic dermatitis
  14. berylliosis
  15. bursitis
  16. carpal tunnel syndrome
  17. chorioretinitis
  18. chronic lung disease (CLD)
  19. chronic lymphocytic leukemia (CLL)
  20. chronic obstructive pulmonary disease (COPD)
  21. Churg-Strauss syndrome
  22. congenital adrenal hyperplasia
  23. contact dermatitis
  24. corneal ulcer
  25. Crohn’s disease
  26. cutaneous T-cell lymphoma (CTCL)
  27. dermatitis herpetiformis
  28. dermatomyositis
  29. discoid lupus erythematosus
  30. endophthalmitis
  31. epicondylitis
  32. erythema multiforme
  33. erythroblastopenia
  34. exfoliative dermatitis
  35. food allergy
  36. gouty arthritis
  37. granuloma annulare
  38. Graves’ ophthalmopathy
  39. hemolytic anemia
  40. hemorrhoids
  41. herpes zoster ocular infection
  42. Hodgkin lymphoma
  43. hypercalcemia
  44. hypoglycemia
  45. hypoplastic anemia
  46. hypotension
  47. immune thrombocytopenic purpura (ITP)
  48. insect bites or stings
  49. iritis
  50. juvenile rheumatoid arthritis (JRA)
  51. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
  52. keloids
  53. keratitis
  54. lichen planus
  55. lichen simplex
  56. lichen striatus
  57. Loeffler’s syndrome
  58. mixed connective tissue disease
  59. multiple myeloma
  60. mycosis fungoides
  61. necrobiosis lipoidica diabeticorum
  62. nephrotic syndrome
  63. non-Hodgkin’s lymphoma (NHL)
  64. optic neuritis
  65. osteoarthritis
  66. pemphigus
  67. perennial allergies
  68. pityriasis rosea
  69. pneumonitis
  70. polyarteritis nodosa
  71. polychondritis
  72. polymorphous light eruption
  73. polymyositis
  74. pompholyx
  75. postoperative ocular inflammation
  76. proctitis
  77. proteinuria
  78. pruritus
  79. psoriasis
  80. psoriatic arthritis
  81. pulmonary edema
  82. rheumatic carditis
  83. rheumatoid arthritis
  84. Rhus dermatitis
  85. sarcoidosis
  86. seasonal allergies
  87. seborrheic dermatitis
  88. septic shock
  89. serum sickness
  90. Stevens-Johnson syndrome
  91. systemic lupus erythematosus (SLE)
  92. temporal arteritis
  93. tenosynovitis
  94. thrombocytopenia
  95. thyroiditis
  96. trichinosis
  97. tuberculosis infection
  98. ulcerative colitis
  99. urticaria
  100. uveitis
  101. vernal keratoconjunctivitis
  102. Wegener’s granulomatosis
  103. xerosis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acneiform rash
  4. adrenocortical insufficiency
  5. alopecia
  6. amenorrhea
  7. amnesia
  8. anaphylactoid reactions
  9. anemia
  10. angina
  11. angioedema
  12. anorexia
  13. anxiety
  14. appetite stimulation
  15. arrhythmia exacerbation
  16. arthralgia
  17. arthropathy
  18. avascular necrosis
  19. blurred vision
  20. bone fractures
  21. bradycardia
  22. candidiasis
  23. cardiac arrest
  24. cardiomyopathy
  25. cataracts
  26. constipation
  27. contact dermatitis
  28. Cushing’s syndrome
  29. delirium
  30. depression
  31. diabetes mellitus
  32. diaphoresis
  33. diarrhea
  34. dizziness
  35. dysmenorrhea
  36. ecchymosis
  37. edema
  38. EEG changes
  39. elevated hepatic enzymes
  40. emotional lability
  41. erythema
  42. esophageal ulceration
  43. euphoria
  44. exfoliative dermatitis
  45. exophthalmos
  46. fever
  47. fluid retention
  48. folliculitis
  49. gastritis
  50. GI bleeding
  51. GI perforation
  52. glossitis
  53. glycosuria
  54. growth inhibition
  55. hallucinations
  56. headache
  57. heart failure
  58. hepatomegaly
  59. hiccups
  60. hirsutism
  61. hypercholesterolemia
  62. hyperglycemia
  63. hypernatremia
  64. hypertension
  65. hyperthyroidism
  66. hypertrichosis
  67. hypocalcemia
  68. hypokalemia
  69. hypotension
  70. hypothalamic-pituitary-adrenal (HPA) suppression
  71. hypothyroidism
  72. immunosuppression
  73. impaired cognition
  74. impaired wound healing
  75. increased intracranial pressure
  76. infection
  77. injection site reaction
  78. insomnia
  79. irritability
  80. lethargy
  81. leukocytosis
  82. lupus-like symptoms
  83. maculopapular rash
  84. malaise
  85. mania
  86. memory impairment
  87. menstrual irregularity
  88. metabolic alkalosis
  89. miliaria
  90. myalgia
  91. myocardial infarction
  92. myopathy
  93. nausea
  94. neuritis
  95. ocular hypertension
  96. ocular infection
  97. optic neuritis
  98. osteopenia
  99. osteoporosis
  100. palpitations
  101. pancreatitis
  102. papilledema
  103. paresthesias
  104. peptic ulcer
  105. perineal pain
  106. peripheral neuropathy
  107. petechiae
  108. phlebitis
  109. physiological dependence
  110. postmenopausal bleeding
  111. pruritus
  112. pseudotumor cerebri
  113. psychosis
  114. pulmonary edema
  115. purpura
  116. rash
  117. restlessness
  118. retinopathy
  119. seizures
  120. sinus tachycardia
  121. skin atrophy
  122. skin hyperpigmentation
  123. skin hypopigmentation
  124. skin irritation
  125. skin ulcer
  126. sodium retention
  127. striae
  128. stroke
  129. syncope
  130. telangiectasia
  131. tendon rupture
  132. thromboembolism
  133. thrombosis
  134. tolerance
  135. urticaria
  136. vasculitis
  137. vertigo
  138. visual impairment
  139. vomiting
  140. weakness
  141. weight gain
  142. weight loss
  143. withdrawal
  144. xerosis

Monitoring Parameters

  • blood glucose
  • blood pressure
  • growth rate
  • serum cortisol
  • serum potassium
  • weight

Contraindications

  • abrupt discontinuation
  • acne rosacea
  • acne vulgaris
  • asthma
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • cataracts
  • coagulopathy
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • diverticulitis
  • epidural administration
  • fungal infection
  • geriatric
  • GI disease
  • GI perforation
  • glaucoma
  • growth inhibition
  • heart failure
  • hemophilia
  • hepatic disease
  • herpes infection
  • hypertension
  • hypothyroidism
  • immunosuppression
  • increased intracranial pressure
  • infection
  • inflammatory bowel disease
  • intrathecal administration
  • measles
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • ocular exposure
  • ocular infection
  • ophthalmic administration
  • osteoporosis
  • peptic ulcer disease
  • perioral dermatitis
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • premature neonates
  • psychosis
  • renal disease
  • seizure disorder
  • skin abrasion
  • skin atrophy
  • sulfite hypersensitivity
  • surgery
  • thromboembolic disease
  • tuberculosis
  • ulcerative colitis
  • vaccination
  • varicella
  • viral infection
  • visual disturbance

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Acetohexamide
  • Adalimumab
  • Albiglutide
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Altretamine
  • Ambenonium Chloride
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Argatroban
  • Arsenic Trioxide
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azathioprine
  • Azilsartan; Chlorthalidone
  • Basiliximab
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bepridil
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Bortezomib
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Bupropion
  • Bupropion; Naltrexone
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carmustine, BCNU
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorambucil
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Cisatracurium
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clofarabine
  • Codeine; Phenylephrine; Promethazine
  • Colestipol
  • Conivaptan
  • Cosyntropin
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Denileukin Diftitox
  • Denosumab
  • Desmopressin
  • Dextran
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digoxin
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dofetilide
  • Doxacurium
  • Droperidol
  • Dulaglutide
  • Echinacea
  • Econazole
  • Efalizumab
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erlotinib
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Estramustine
  • Estrogens
  • Exenatide
  • Fluconazole
  • Fluoxymesterone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium Ga 68 Dotatate
  • Gemcitabine
  • Gentamicin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycerol Phenylbutyrate
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Haloperidol
  • Hemin
  • Heparin
  • Hetastarch
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyurea
  • Hylan G-F 20
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Incretin Mimetics
  • Indapamide
  • Inebilizumab
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Iohexol
  • Iopamidol
  • Isoproterenol
  • Isotretinoin
  • L-Asparaginase Escherichia coli
  • Levetiracetam
  • Levomethadyl
  • Linagliptin; Metformin
  • Liraglutide
  • Live Vaccines
  • Lixisenatide
  • Lomustine, CCNU
  • Loop diuretics
  • Macimorelin
  • Magnesium Salicylate
  • Mannitol
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Meglitinides
  • Melphalan
  • Mepenzolate
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methacholine
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Metyrapone
  • Micafungin
  • Mifepristone
  • Mitotane
  • Mitoxantrone
  • Mivacurium
  • Moxifloxacin
  • Muromonab-CD3
  • Natalizumab
  • Nateglinide
  • Nelarabine
  • Neostigmine
  • Neuromuscular blockers
  • Nicardipine
  • Nonsteroidal antiinflammatory drugs
  • Ocrelizumab
  • Ondansetron
  • Oxymetholone
  • Ozanimod
  • Pancuronium
  • Pegaspargase
  • Penicillamine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Physostigmine
  • Pimozide
  • Potassium
  • Potassium Chloride
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Propranolol
  • Purine analogs
  • Pyridostigmine
  • Quetiapine
  • Quinolones
  • Rapacuronium
  • Regular Insulin
  • Repaglinide
  • Ritodrine
  • Rituximab
  • Rituximab; Hyaluronidase
  • Rocuronium
  • Salicylates
  • Salsalate
  • Sargramostim, GM-CSF
  • Semaglutide
  • SGLT2 Inhibitors
  • Siponimod
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium Chloride
  • Sodium Phenylbutyrate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Somatropin, rh-GH
  • Succinylcholine
  • Sulfonylureas
  • Telbivudine
  • Testosterone
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Tobramycin
  • Tocilizumab
  • Tolazamide
  • Tolbutamide
  • Tositumomab
  • Tranexamic Acid
  • Tretinoin, ATRA
  • Tuberculin Purified Protein Derivative, PPD
  • Tubocurarine
  • Vancomycin
  • Vecuronium
  • Vigabatrin
  • Vinblastine
  • Vincristine Liposomal
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zafirlukast
  • Zileuton
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