Hydrocodone Potassium Guaiacolsulfonate Pseudoephedrine

Hydrocodone Potassium Guaiacolsulfonate Pseudoephedrine Brand Names

Hydro-Pro-D | Pro Cof D | Protuss D

What is Hydrocodone Potassium Guaiacolsulfonate Pseudoephedrine

NOTE: These products are discontinued in the U.S.

Hydrocodone potassium guaiacolsulfonate pseudoephedrine are used together in an oral preparation to relieve cough and to facilitate bronchial and sinus drainage.

Specifically, this combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, pertussis, or influenza. Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

The antitussive and sedative properties of hydrocodone are greater than codeine. Hydrocodone also has analgesic properties, although it is not used for this purpose when combined with potassium guaiacolsulfonate and pseudoephedrine.

Potassium guaiacolsulfonate has historically been used as an oral expectorant and is thought to be useful for a dry, non-productive cough which tends to injure the respiratory mucous membranes.

Although efficacy is not proven, potassium guaiacolsulfonate is used to loosen and thin sputum and bronchial secretions and to ease expectoration. Although this action can decrease secretions, indirectly diminishing the tendency to cough, potassium guaiacolsulfonate is not considered an antitussive agent.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.

This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Indications

  • cough
  • nasal congestion

For the temporary relief of dry, non-productive cough and nasal congestion due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza

Side Effects

  1. abdominal pain
  2. amenorrhea
  3. angina
  4. anorexia
  5. anxiety
  6. arrhythmia exacerbation
  7. biliary obstruction
  8. blurred vision
  9. bradycardia
  10. colitis
  11. confusion
  12. constipation
  13. contact dermatitis
  14. diaphoresis
  15. diarrhea
  16. dizziness
  17. drowsiness
  18. dysphoria
  19. dysuria
  20. erythema
  21. euphoria
  22. flushing
  23. gastritis
  24. hallucinations
  25. headache
  26. hyperamylasemia
  27. hypertension
  28. hyponatremia
  29. hypotension
  30. infertility
  31. insomnia
  32. libido decrease
  33. miosis
  34. myocardial infarction
  35. nausea
  36. neonatal abstinence syndrome
  37. ocular hypertension
  38. orthostatic hypotension
  39. palpitations
  40. photophobia
  41. physiological dependence
  42. premature ventricular contractions (PVCs)
  43. pruritus
  44. psychosis
  45. rash
  46. respiratory depression
  47. restlessness
  48. seizures
  49. SIADH
  50. sinus tachycardia
  51. stroke
  52. supraventricular tachycardia (SVT)
  53. syncope
  54. urinary retention
  55. vomiting
  56. withdrawal
  57. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acute bronchospasm
  • alcoholism
  • angina
  • asthma
  • bladder obstruction
  • breast-feeding
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • head trauma
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • MAOI therapy
  • neonatal opioid withdrawal syndrome
  • neonates
  • opiate agonist hypersensitivity
  • orthostatic hypotension
  • peripheral vascular disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory insufficiency
  • seizures
  • sleep apnea
  • substance abuse
  • thyrotoxicosis
  • urinary retention

Interactions

  • Abiraterone
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  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
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  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
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  • Palonosetron
  • Panobinostat
  • Papaverine
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pegvisomant
  • Penbutolol
  • Penicillin G
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Piroxicam
  • Polyethylene Glycol
  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Posaconazole
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procaine
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propofol
  • Propoxyphene
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Riociguat
  • Risperidone
  • Ritonavir
  • Rizatriptan
  • Rofecoxib
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Sacubitril; Valsartan
  • Safinamide
  • Salmeterol
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Selexipag
  • Selpercatinib
  • Semaglutide
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Sodium Polystyrene Sulfonate
  • Solifenacin
  • Solriamfetol
  • Sorbitol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfonylureas
  • Sulindac
  • Sumatriptan
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Tedizolid
  • Telaprevir
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Ticagrelor
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolmetin
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimethoprim
  • Triprolidine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valdecoxib
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vasodilators
  • Vasopressors
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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