Hydrocodone Pseudoephedrine

Hydrocodone Pseudoephedrine Brand Names

ColdCough HCM | Detussin | H Tuss D | HC Tussive D | Histussin D | Hytussin | Iotussin D | P V Tussin | Pancof HC | Rezira | SymTan | Tuss S

What is Hydrocodone Pseudoephedrine

Hydrocodone and pseudoephedrine are used together in an oral preparation to relieve cough and congestion. This combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, influenza, sinusitis, or bronchitis.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Pseudoephedrine is a sympathomimetic decongestant agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.

This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Opioid cough and cold medicines that contain hydrocodone are contraindicated in pediatric patients; risks of these medicines outweigh their benefits in patients younger than 18 years.

Indications

• common cold
• cough
• nasal congestion

For the treatment of cough and nasal congestion due to the common cold

Side Effects

1. angina
2. anxiety
3. arrhythmia exacerbation
4. blurred vision
5. confusion
6. constipation
7. dizziness
8. drowsiness
9. dysphoria
10. dysuria
11. emotional lability
12. euphoria
13. headache
14. hypotension
15. impaired cognition
16. insomnia
17. lethargy
18. myocardial infarction
19. nausea
20. palpitations
21. photophobia
22. premature ventricular contractions (PVCs)
23. pruritus
24. psychological dependence
25. rash
26. respiratory depression
27. sinus tachycardia
28. stroke
29. supraventricular tachycardia (SVT)
30. tolerance
31. urinary retention
32. urticaria
33. vomiting
34. weakness
35. withdrawal
36. xerophthalmia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute abdomen
• acute myocardial infarction
• adrenal insufficiency
• angina
• anticholinergic medications
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coadministration with other CNS depressants
• constipation
• coronary artery disease
• diabetes mellitus
• diarrhea
• driving or operating machinery
• emphysema
• ethanol ingestion
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• labor
• MAOI therapy
• neonatal opioid withdrawal syndrome
• neonates
• obstetric delivery
• opiate agonist hypersensitivity
• pregnancy
• prostatic hypertrophy
• renal impairment
• respiratory depression
• substance abuse
• ulcerative colitis
• urethral stricture
• urinary retention
• ventricular tachycardia

Interactions

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