Hydrocodone Potassium Guaiacolsulfonate

Hydrocodone Potassium Guaiacolsulfonate Brand Names

Atuss EX | Atuss NX | De-Chlor NX | Entuss | Hydone | Hydron EX | Hydron KGS | Hydro-Pro | Hy-KXP | KGS HC | Marcof | M-Clear | M-Clear JR | Mintuss EX | Mintuss NX | Pro Cof | Pro-Clear | Prolex DH | Protuss | P-Tuss

What is Hydrocodone Potassium Guaiacolsulfonate

NOTE: These products are discontinued in the U.S.

Hydrocodone and potassium guaiacolsulfonate are used together in an oral preparation to relieve cough.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Potassium guaiacolsulfonate has historically been used as an oral expectorant.

Although efficacy is not proven, potassium guaiacolsulfonate was used to loosen and thin sputum and bronchial secretions and to ease expectoration. An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.

New regulatory guidelines regarding expectorants were issued by the FDA in October 2003.

Indications

• cough

For the temporary relief of dry, non-productive cough due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza

Side Effects

1. amenorrhea
2. biliary obstruction
3. blurred vision
4. bradycardia
5. confusion
6. constipation
7. dizziness
8. drowsiness
9. dysphoria
10. euphoria
11. flushing
12. gastritis
13. hallucinations
14. headache
15. hyperamylasemia
16. hypertension
17. hyponatremia
18. hypotension
19. infertility
20. libido decrease
21. miosis
22. nausea
23. neonatal abstinence syndrome
24. oliguria
25. orthostatic hypotension
26. palpitations
27. physiological dependence
28. pruritus
29. respiratory depression
30. restlessness
31. SIADH
32. sinus tachycardia
33. syncope
34. tolerance
35. urinary retention
36. vomiting
37. withdrawal
38. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute abdomen
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• constipation
• diarrhea
• driving or operating machinery
• emphysema
• fever
• geriatric
• GI disease
• GI obstruction
• head trauma
• headache
• heart failure
• hepatic disease
• hypovolemia
• ileus
• increased intracranial pressure
• infants
• inflammatory bowel disease
• neonates
• opiate agonist hypersensitivity
• orthostatic hypotension
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• respiratory depression
• seizures
• substance abuse
• surgery
• tobacco smoking
• ulcerative colitis
• urethral stricture
• urinary retention
• vomiting

Interactions

• Abiraterone
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Almotriptan
• Alosetron
• Alprazolam
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Alvimopan
• Amide local anesthetics
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
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• Asenapine
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• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
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• Aspirin, ASA; Oxycodone
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• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
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• Chlorpheniramine; Phenylephrine
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• Diazepam
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• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dolasetron
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
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• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Enzalutamide
• Eplerenone
• Eprosartan
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• food
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• General anesthetics
• Glycopyrrolate
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• Granisetron
• grapefruit juice
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• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Ibuprofen
• Hydrocortisone
• Hydromorphone
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
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• Ibuprofen; Pseudoephedrine
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