Hydrocodone Potassium Guaiacolsulfonate Brand Names
Atuss EX | Atuss NX | De-Chlor NX | Entuss | Hydone | Hydron EX | Hydron KGS | Hydro-Pro | Hy-KXP | KGS HC | Marcof | M-Clear | M-Clear JR | Mintuss EX | Mintuss NX | Pro Cof | Pro-Clear | Prolex DH | Protuss | P-Tuss
What is Hydrocodone Potassium Guaiacolsulfonate
NOTE: These products are discontinued in the U.S.
Hydrocodone and potassium guaiacolsulfonate are used together in an oral preparation to relieve cough.
Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.
Potassium guaiacolsulfonate has historically been used as an oral expectorant.
Although efficacy is not proven, potassium guaiacolsulfonate was used to loosen and thin sputum and bronchial secretions and to ease expectoration. An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.
New regulatory guidelines regarding expectorants were issued by the FDA in October 2003.
Indications
- cough
For the temporary relief of dry, non-productive cough due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza
Side Effects
- amenorrhea
- biliary obstruction
- blurred vision
- bradycardia
- confusion
- constipation
- dizziness
- drowsiness
- dysphoria
- euphoria
- flushing
- gastritis
- hallucinations
- headache
- hyperamylasemia
- hypertension
- hyponatremia
- hypotension
- infertility
- libido decrease
- miosis
- nausea
- neonatal abstinence syndrome
- oliguria
- orthostatic hypotension
- palpitations
- physiological dependence
- pruritus
- respiratory depression
- restlessness
- SIADH
- sinus tachycardia
- syncope
- tolerance
- urinary retention
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- acute abdomen
- asthma
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- constipation
- diarrhea
- driving or operating machinery
- emphysema
- fever
- geriatric
- GI disease
- GI obstruction
- head trauma
- headache
- heart failure
- hepatic disease
- hypovolemia
- ileus
- increased intracranial pressure
- infants
- inflammatory bowel disease
- neonates
- opiate agonist hypersensitivity
- orthostatic hypotension
- pregnancy
- prostatic hypertrophy
- renal failure
- renal impairment
- respiratory depression
- seizures
- substance abuse
- surgery
- tobacco smoking
- ulcerative colitis
- urethral stricture
- urinary retention
- vomiting
Interactions
- Abiraterone
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
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- Alvimopan
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- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
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- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
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