Hydrocodone Potassium Guaiacolsulfonate

Hydrocodone Potassium Guaiacolsulfonate Brand Names

What is Hydrocodone Potassium Guaiacolsulfonate

NOTE: These products are discontinued in the U.S.

Hydrocodone and potassium guaiacolsulfonate are used together in an oral preparation to relieve cough.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Potassium guaiacolsulfonate has historically been used as an oral expectorant.

Although efficacy is not proven, potassium guaiacolsulfonate was used to loosen and thin sputum and bronchial secretions and to ease expectoration. An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.

New regulatory guidelines regarding expectorants were issued by the FDA in October 2003.

Indications

cough

For the temporary relief of dry, non-productive cough due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza

Side Effects

amenorrhea
biliary obstruction
blurred vision
bradycardia
confusion
constipation
dizziness
drowsiness
dysphoria
euphoria
flushing
gastritis
hallucinations
headache
hyperamylasemia
hypertension
hyponatremia
hypotension
infertility
libido decrease
miosis
nausea
neonatal abstinence syndrome
oliguria
orthostatic hypotension
palpitations
physiological dependence
pruritus
respiratory depression
restlessness
SIADH
sinus tachycardia
syncope
tolerance
urinary retention
vomiting
withdrawal
xerostomia

Monitoring Parameters

laboratory monitoring not necessary

Contraindications

abrupt discontinuation
acute abdomen
asthma
bladder obstruction
breast-feeding
bronchitis
cardiac arrhythmias
cardiac disease
children
chronic obstructive pulmonary disease (COPD)
constipation
diarrhea
driving or operating machinery
emphysema
fever
geriatric
GI disease
GI obstruction
head trauma
headache
heart failure
hepatic disease
hypovolemia
ileus
increased intracranial pressure
infants
inflammatory bowel disease
neonates
opiate agonist hypersensitivity
orthostatic hypotension
pregnancy
prostatic hypertrophy
renal failure
renal impairment
respiratory depression
seizures
substance abuse
surgery
tobacco smoking
ulcerative colitis
urethral stricture
urinary retention
vomiting

Interactions

Abiraterone
Acetaminophen; Butalbital
Acetaminophen; Butalbital; Caffeine
Acetaminophen; Butalbital; Caffeine; Codeine
Acetaminophen; Caffeine; Dihydrocodeine
Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
Acetaminophen; Codeine
Acetaminophen; Dextromethorphan; Doxylamine
Acetaminophen; Dichloralphenazone; Isometheptene
Acetaminophen; Diphenhydramine
Acetaminophen; Oxycodone
Acetaminophen; Pentazocine
Acetaminophen; Propoxyphene
Acetaminophen; Tramadol
Acrivastine; Pseudoephedrine
Aldesleukin, IL-2
Alfentanil
Aliskiren
Aliskiren; Amlodipine
Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
Aliskiren; Hydrochlorothiazide, HCTZ
Aliskiren; Valsartan
Almotriptan
Alosetron
Alprazolam
Aluminum Hydroxide; Magnesium Hydroxide
Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
Alvimopan
Amide local anesthetics
Amifampridine
Amiloride
Amiloride; Hydrochlorothiazide, HCTZ
Amiodarone
Amitriptyline; Chlordiazepoxide
Amlodipine
Amlodipine; Atorvastatin
Amlodipine; Benazepril
Amlodipine; Celecoxib
Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
Amlodipine; Olmesartan
Amlodipine; Telmisartan
Amlodipine; Valsartan
Ammonium Chloride
Amobarbital
Amoxapine
Amoxicillin; Clarithromycin; Lansoprazole
Amoxicillin; Clarithromycin; Omeprazole
Amphetamine
Amphetamine; Dextroamphetamine
Amphetamines
Angiotensin II receptor antagonists
Angiotensin-converting enzyme inhibitors
Anticholinergics
Apalutamide
Apomorphine
Apraclonidine
Aprepitant, Fosaprepitant
Aripiprazole
Armodafinil
Artemether; Lumefantrine
Articaine; Epinephrine
Asenapine
Aspirin, ASA; Butalbital; Caffeine
Aspirin, ASA; Butalbital; Caffeine; Codeine
Aspirin, ASA; Caffeine; Dihydrocodeine
Aspirin, ASA; Caffeine; Orphenadrine
Aspirin, ASA; Carisoprodol
Aspirin, ASA; Carisoprodol; Codeine
Aspirin, ASA; Oxycodone
Atazanavir
Atazanavir; Cobicistat
Atenolol; Chlorthalidone
Atropine
Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
Atropine; Difenoxin
Atropine; Diphenoxylate
Atropine; Edrophonium
Atropine; Hyoscyamine; Phenobarbital; Scopolamine
Azelastine
Azelastine; Fluticasone
Azilsartan
Azilsartan; Chlorthalidone
Baclofen
Barbiturates
Beclomethasone
Belladonna Alkaloids; Ergotamine; Phenobarbital
Belladonna; Opium
Benazepril
Benazepril; Hydrochlorothiazide, HCTZ
Bendroflumethiazide; Nadolol
Benzhydrocodone; Acetaminophen
Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
Benzonatate
Benzphetamine
Benztropine
Betamethasone
Bethanechol
Bexarotene
Bicalutamide
Bisacodyl
Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
Bismuth Subsalicylate
Bismuth Subsalicylate; Metronidazole; Tetracycline
Bisoprolol; Hydrochlorothiazide, HCTZ
Boceprevir
Bosentan
Brexpiprazole
Brigatinib
Brimonidine
Brimonidine; Brinzolamide
Brimonidine; Timolol
Brompheniramine
Brompheniramine; Carbetapentane; Phenylephrine
Brompheniramine; Dextromethorphan; Guaifenesin
Brompheniramine; Dextromethorphan; Phenylephrine
Brompheniramine; Guaifenesin; Hydrocodone
Brompheniramine; Hydrocodone; Pseudoephedrine
Brompheniramine; Pseudoephedrine
Budesonide
Budesonide; Formoterol
Bumetanide
Bupivacaine
Bupivacaine Liposomal
Bupivacaine; Lidocaine
Buprenorphine
Buprenorphine; Naloxone
Bupropion
Bupropion; Naltrexone
Buspirone
Butabarbital
Butorphanol
Calcium Carbonate; Magnesium Hydroxide
Candesartan
Candesartan; Hydrochlorothiazide, HCTZ
Cannabidiol
Capsaicin; Metaxalone
Captopril
Captopril; Hydrochlorothiazide, HCTZ
Carbamazepine
Carbetapentane; Chlorpheniramine
Carbetapentane; Chlorpheniramine; Phenylephrine
Carbetapentane; Diphenhydramine; Phenylephrine
Carbetapentane; Guaifenesin
Carbetapentane; Guaifenesin; Phenylephrine
Carbetapentane; Phenylephrine
Carbetapentane; Phenylephrine; Pyrilamine
Carbetapentane; Pseudoephedrine
Carbetapentane; Pyrilamine
Carbinoxamine
Carbinoxamine; Dextromethorphan; Pseudoephedrine
Carbinoxamine; Hydrocodone; Phenylephrine
Carbinoxamine; Hydrocodone; Pseudoephedrine
Carbinoxamine; Phenylephrine
Carbinoxamine; Pseudoephedrine
Cariprazine
Carisoprodol
Castor Oil
Celecoxib
Cenobamate
Ceritinib
Cetirizine
Cetirizine; Pseudoephedrine
Chlophedianol; Dexbrompheniramine
Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
Chloral Hydrate
Chloramphenicol
Chlorcyclizine
Chlordiazepoxide
Chlordiazepoxide; Clidinium
Chloroprocaine
Chlorothiazide
Chlorpheniramine
Chlorpheniramine; Codeine
Chlorpheniramine; Dextromethorphan
Chlorpheniramine; Dextromethorphan; Phenylephrine
Chlorpheniramine; Dihydrocodeine; Phenylephrine
Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
Chlorpheniramine; Hydrocodone
Chlorpheniramine; Hydrocodone; Phenylephrine
Chlorpheniramine; Hydrocodone; Pseudoephedrine
Chlorpheniramine; Phenylephrine
Chlorpheniramine; Pseudoephedrine
Chlorpromazine
Chlorthalidone
Chlorthalidone; Clonidine
Chlorzoxazone
Ciclesonide
Cimetidine
Cinacalcet
Ciprofloxacin
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Clonidine
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Clozapine
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Codeine; Guaifenesin
Codeine; Phenylephrine; Promethazine
Codeine; Promethazine
COMT inhibitors
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Crofelemer
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Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
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Dextromethorphan; Promethazine
Dextromethorphan; Quinidine
Diazepam
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Dicyclomine
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Digoxin
Dihydrocodeine; Guaifenesin; Pseudoephedrine
Diltiazem
Dimenhydrinate
Diphenhydramine
Diphenhydramine; Hydrocodone; Phenylephrine
Diphenhydramine; Ibuprofen
Diphenhydramine; Naproxen
Diphenhydramine; Phenylephrine
Dolasetron
Doxylamine
Doxylamine; Pyridoxine
Dronabinol
Dronedarone
Droperidol
Drospirenone
Drospirenone; Estradiol
Drospirenone; Ethinyl Estradiol
Drospirenone; Ethinyl Estradiol; Levomefolate
Duloxetine
Duvelisib
Efavirenz
Efavirenz; Emtricitabine; Tenofovir
Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
Elagolix
Elagolix; Estradiol; Norethindrone acetate
Elbasvir; Grazoprevir
Eletriptan
Elexacaftor; tezacaftor; ivacaftor
Eliglustat
Eltrombopag
Eluxadoline
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
Enalapril, Enalaprilat
Enalapril; Felodipine
Enalapril; Hydrochlorothiazide, HCTZ
Enflurane
Enzalutamide
Eplerenone
Eprosartan
Eprosartan; Hydrochlorothiazide, HCTZ
Erythromycin
Erythromycin; Sulfisoxazole
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Fluoxetine; Olanzapine
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Fluticasone; Salmeterol
Fluticasone; Umeclidinium; Vilanterol
Fluticasone; Vilanterol
Fluvoxamine
food
Formoterol; Mometasone
Fosamprenavir
Fosinopril
Fosinopril; Hydrochlorothiazide, HCTZ
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Furosemide
Gabapentin
General anesthetics
Glycopyrrolate
Glycopyrrolate; Formoterol
Granisetron
grapefruit juice
Guanabenz
Guanfacine
Haloperidol
Halothane
Heparin
Homatropine; Hydrocodone
Hydralazine; Hydrochlorothiazide, HCTZ
Hydrochlorothiazide, HCTZ
Hydrochlorothiazide, HCTZ; Irbesartan
Hydrochlorothiazide, HCTZ; Lisinopril
Hydrochlorothiazide, HCTZ; Losartan
Hydrochlorothiazide, HCTZ; Methyldopa
Hydrochlorothiazide, HCTZ; Metoprolol
Hydrochlorothiazide, HCTZ; Moexipril
Hydrochlorothiazide, HCTZ; Olmesartan
Hydrochlorothiazide, HCTZ; Propranolol
Hydrochlorothiazide, HCTZ; Quinapril
Hydrochlorothiazide, HCTZ; Spironolactone
Hydrochlorothiazide, HCTZ; Telmisartan
Hydrochlorothiazide, HCTZ; Triamterene
Hydrochlorothiazide, HCTZ; Valsartan
Hydrocodone; Ibuprofen
Hydrocortisone
Hydromorphone
Hydroxyzine
Hyoscyamine
Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
Ibuprofen
Ibuprofen; Oxycodone
Ibuprofen; Pseudoephedrine
Idelalisib
Iloperidone
Imatinib
Indacaterol; Glycopyrrolate
Indapamide
Indinavir
Indomethacin
Irbesartan
Isavuconazonium
Isocarboxazid
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Isoniazid, INH
Isoniazid, INH; Pyrazinamide, PZA; Rifampin
Isoniazid, INH; Rifampin
Istradefylline
Itraconazole
Ivacaftor
Ketamine
Ketoconazole
Ketoprofen
Ketorolac
Lactulose
Lansoprazole; Naproxen
Lapatinib
Larotrectinib
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Lefamulin
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Lesinurad
Lesinurad; Allopurinol
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Levobupivacaine
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Levomilnacipran
Levorphanol
Lidocaine
Lidocaine; Prilocaine
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Linezolid
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Loperamide; Simethicone
Lopinavir; Ritonavir
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Meperidine; Promethazine
Mephobarbital
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Metaxalone
Methadone
Methamphetamine
Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
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Methscopolamine
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Methylene Blue
Methylphenidate
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Metolazone
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Metyrosine
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Minocycline
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Morphine; Naltrexone
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Nafcillin
Nalbuphine
Naloxone
Naltrexone
Naproxen
Naproxen; Pseudoephedrine
Naproxen; Sumatriptan
Naratriptan
Nebivolol; Valsartan
Nefazodone
Nelfinavir
Nesiritide, BNP
Netupitant, Fosnetupitant; Palonosetron
Nevirapine
Nicardipine
Nilotinib
Nitroglycerin
Nonsteroidal antiinflammatory drugs
Olanzapine
Olmesartan
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Osilodrostat
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Ozanimod
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Pentobarbital
Perampanel
Perindopril
Perindopril; Amlodipine
Perphenazine
Perphenazine; Amitriptyline
Phenelzine
Phenobarbital
Phentermine; Topiramate
Phenylephrine; Promethazine
Phenytoin
Pimozide
Piroxicam
Polyethylene Glycol
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Posaconazole
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Hydrocodone Potassium Guaiacolsulfonate