Hydrocodone Potassium Guaiacolsulfonate

Hydrocodone Potassium Guaiacolsulfonate Brand Names

Atuss EX | Atuss NX | De-Chlor NX | Entuss | Hydone | Hydron EX | Hydron KGS | Hydro-Pro | Hy-KXP | KGS HC | Marcof | M-Clear | M-Clear JR | Mintuss EX | Mintuss NX | Pro Cof | Pro-Clear | Prolex DH | Protuss | P-Tuss

What is Hydrocodone Potassium Guaiacolsulfonate

NOTE: These products are discontinued in the U.S.

Hydrocodone and potassium guaiacolsulfonate are used together in an oral preparation to relieve cough.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Potassium guaiacolsulfonate has historically been used as an oral expectorant.

Although efficacy is not proven, potassium guaiacolsulfonate was used to loosen and thin sputum and bronchial secretions and to ease expectoration. An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.

New regulatory guidelines regarding expectorants were issued by the FDA in October 2003.

Indications

  • cough

For the temporary relief of dry, non-productive cough due to minor throat and bronchial irritation as may occur with the common cold, pertussis, or influenza

Side Effects

  1. amenorrhea
  2. biliary obstruction
  3. blurred vision
  4. bradycardia
  5. confusion
  6. constipation
  7. dizziness
  8. drowsiness
  9. dysphoria
  10. euphoria
  11. flushing
  12. gastritis
  13. hallucinations
  14. headache
  15. hyperamylasemia
  16. hypertension
  17. hyponatremia
  18. hypotension
  19. infertility
  20. libido decrease
  21. miosis
  22. nausea
  23. neonatal abstinence syndrome
  24. oliguria
  25. orthostatic hypotension
  26. palpitations
  27. physiological dependence
  28. pruritus
  29. respiratory depression
  30. restlessness
  31. SIADH
  32. sinus tachycardia
  33. syncope
  34. tolerance
  35. urinary retention
  36. vomiting
  37. withdrawal
  38. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acute abdomen
  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • constipation
  • diarrhea
  • driving or operating machinery
  • emphysema
  • fever
  • geriatric
  • GI disease
  • GI obstruction
  • head trauma
  • headache
  • heart failure
  • hepatic disease
  • hypovolemia
  • ileus
  • increased intracranial pressure
  • infants
  • inflammatory bowel disease
  • neonates
  • opiate agonist hypersensitivity
  • orthostatic hypotension
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • respiratory depression
  • seizures
  • substance abuse
  • surgery
  • tobacco smoking
  • ulcerative colitis
  • urethral stricture
  • urinary retention
  • vomiting

Interactions

  • Abiraterone
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alosetron
  • Alprazolam
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Alvimopan
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  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
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  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
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  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
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  • food
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  • grapefruit juice
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  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine
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  • Ibuprofen
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