Hydrochlorothiazide Propranolol

Hydrochlorothiazide Propranolol Brand Name– Inderide | Inderide LA

What is Hydrochlorothiazide Propranolol

Hydrochlorothiazide and propranolol are used together in an oral preparation to treat hypertension.

Hydrochlorothiazide is a thiazide diuretic. Propranolol is a nonspecific, highly lipid-soluble beta-blocker.

Hydrochlorothiazide and propranolol have additive hypotensive activity. The fixed combination product offers convenience for patients requiring both medications for blood pressure control.

Inderide® (hydrochlorothiazide propranolol) was approved by the FDA in June 1979.

Indications

  • hypertension

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. anaphylactoid reactions
  5. anorexia
  6. aplastic anemia
  7. AV block
  8. azotemia
  9. blurred vision
  10. bradycardia
  11. bronchospasm
  12. confusion
  13. constipation
  14. depression
  15. diabetes mellitus
  16. diaphoresis
  17. diarrhea
  18. dizziness
  19. dyspnea
  20. elevated hepatic enzymes
  21. emotional lability
  22. erythema multiforme
  23. exfoliative dermatitis
  24. fatigue
  25. fever
  26. glycosuria
  27. gout
  28. hallucinations
  29. headache
  30. heart failure
  31. hemolytic anemia
  32. hypercalcemia
  33. hypercholesterolemia
  34. hyperglycemia
  35. hyperkalemia
  36. hypertension
  37. hypertriglyceridemia
  38. hyperuricemia
  39. hypochloremia
  40. hypoglycemia
  41. hypokalemia
  42. hypomagnesemia
  43. hyponatremia
  44. hypotension
  45. hypovolemia
  46. impotence (erectile dysfunction)
  47. insomnia
  48. interstitial nephritis
  49. ischemic colitis
  50. jaundice
  51. laryngospasm
  52. lethargy
  53. leukopenia
  54. lupus-like symptoms
  55. memory impairment
  56. metabolic alkalosis
  57. muscle cramps
  58. myopia
  59. nausea
  60. nightmares
  61. ocular hypertension
  62. orthostatic hypotension
  63. palpitations
  64. pancreatitis
  65. paresthesias
  66. pharyngitis
  67. photosensitivity
  68. pneumonitis
  69. polyuria
  70. pruritus
  71. psoriaform rash
  72. purpura
  73. rash
  74. renal failure (unspecified)
  75. restlessness
  76. sialadenitis
  77. sinus tachycardia
  78. Stevens-Johnson syndrome
  79. syncope
  80. thrombocytopenia
  81. thrombosis
  82. thrombotic thrombocytopenic purpura (TTP)
  83. toxic epidermal necrolysis
  84. tremor
  85. urticaria
  86. vasculitis
  87. vertigo
  88. vomiting
  89. weakness
  90. withdrawal
  91. xanthopsia
  92. xerophthalmia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • heart rate
  • serum calcium
  • serum creatinine/BUN
  • serum electrolytes
  • serum magnesium
  • serum uric acid

Contraindications

  • abrupt discontinuation
  • acid/base imbalance
  • acute bronchospasm
  • anuria
  • asthma
  • AV block
  • beta-blocker hypersensitivity
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • electrolyte imbalance
  • emphysema
  • geriatric
  • gout
  • heart failure
  • hepatic disease
  • hypercalcemia
  • hyperglycemia
  • hyperthyroidism
  • hyperuricemia
  • hypochloremia
  • hypoglycemia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • infants
  • labor
  • metabolic alkalosis
  • myasthenia gravis
  • neonates
  • obstetric delivery
  • orthostatic hypotension
  • pancreatitis
  • penicillin hypersensitivity
  • peripheral vascular disease
  • pheochromocytoma
  • preeclampsia
  • pregnancy
  • psoriasis
  • pulmonary edema
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • sympathectomy
  • syncope
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity
  • thyroid disease
  • thyrotoxicosis
  • tobacco smoking
  • vasospastic angina
  • Wolff-Parkinson-White syndrome

Interactions

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  • Acetaminophen; Codeine
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  • Acetaminophen; Dextromethorphan; Pseudoephedrine
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  • food
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  • SGLT2 Inhibitors
  • Silodosin
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sitagliptin
  • Sodium Bicarbonate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Solifenacin
  • Streptozocin
  • Succinylcholine
  • Sufentanil
  • Sulfacetamide
  • Sulfacetamide; Sulfur
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfinpyrazone
  • Sulfonylureas
  • Sulindac
  • Sympathomimetics
  • Tacrine
  • Tamsulosin
  • Tapentadol
  • Tasimelteon
  • Tazarotene
  • Tegaserod
  • Terazosin
  • Terbinafine
  • Terbutaline
  • Testosterone
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazolidinediones
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Tiotropium; Olodaterol
  • Tizanidine
  • tobacco
  • Tocainide
  • Tolazamide
  • Tolbutamide
  • Tolmetin
  • Tolterodine
  • Tolvaptan
  • Topiramate
  • Toremifene
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Tretinoin, ATRA
  • Triamcinolone
  • Trifluoperazine
  • Trihexyphenidyl
  • Trospium
  • Tubocurarine
  • Umeclidinium; Vilanterol
  • Valdecoxib
  • Vecuronium
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Verteporfin
  • Vilazodone
  • Vitamin D
  • Vitamin D analogs
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Warfarin
  • Yohimbine
  • Ziconotide
  • Zileuton
  • Ziprasidone
  • Zolmitriptan