Guaifenesin Phenylephrine

Guaifenesin Phenylephrine Brand Names

Aldex | Aldex G | Ambi | Amidal | Ami-Tex LA 

What is Guaifenesin Phenylephrine

Guaifenesin and phenylephrine are used together in an oral preparation.

Guaifenesin is an expectorant that loosens and thins sputum and bronchial secretions to ease expectoration; the drug has no antitussive activity.

Phenylephrine is a sympathomimetic decongestant agent that causes vasoconstriction and decreases nasal congestion.

Guaifenesin is used for dry, nonproductive cough when there is the presence of tenacious mucus and/or mucus plugs.

The results of a few studies have favored active treatment with guaifenesin over placebo in treating productive cough due to upper respiratory illness (URI).

In patients with chronic bronchitis, guaifenesin, is not recommended for aiding with cough suppression since studies have shown no benefit in reducing cough.

However, the mucolytic properties of guaifenesin may be independently helpful in clearing mucus, and patients may subjectively report benefit to use.

Products containing guaifenesin; phenylephrine are primarily used for the temporary relief of congestion associated with the common cold and other upper respiratory conditions in adults and pediatric patients 4 years and older.

Indications

  1. common cold
  2. cough
  3. eustachian tube congestion
  4. nasal congestion

For the temporary relief of cough and sinus and nasal congestion, including eustachian tube congestion, associated with the common cold, allergic rhinitis, or other upper respiratory conditions

Side Effects

  1. angina
  2. anxiety
  3. arrhythmia exacerbation
  4. colitis
  5. contact dermatitis
  6. delirium
  7. diarrhea
  8. dizziness
  9. dysuria
  10. erythema
  11. hallucinations
  12. headache
  13. hypertension
  14. hypotension
  15. insomnia
  16. intracranial bleeding
  17. myocardial infarction
  18. nausea
  19. nephrolithiasis
  20. ocular hypertension
  21. pallor
  22. palpitations
  23. photophobia
  24. psychological dependence
  25. psychosis
  26. pulmonary edema
  27. rash
  28. restlessness
  29. seizures
  30. sinus tachycardia
  31. stroke
  32. tremor
  33. ventricular tachycardia
  34. vomiting
  35. weakness
  36. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • asthma
  • AV block
  • bradycardia
  • breast-feeding
  • bronchitis
  • bundle-branch block
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • closed-angle glaucoma
  • coronary artery disease
  • diabetes mellitus
  • emphysema
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • infants
  • labor
  • MAOI therapy
  • neonates
  • obstetric delivery
  • peripheral vascular disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • thyroid disease
  • thyrotoxicosis
  • tobacco smoking
  • urinary retention
  • ventricular tachycardia

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Ambrisentan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Arformoterol
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzodiazepines
  • Beta-blockers
  • Betamethasone
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Ciclesonide
  • Clevidipine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Cocaine
  • Colchicine
  • Colchicine; Probenecid
  • Corticosteroids
  • Cortisone
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Deflazacort
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diazepam
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Dorzolamide; Timolol
  • Doxazosin
  • Dronabinol
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esmolol
  • Estazolam
  • Ethacrynic Acid
  • Exenatide
  • Felodipine
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fludrocortisone
  • Flunisolide
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Haloperidol
  • Halothane
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Ibuprofen; Pseudoephedrine
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Ionic Contrast Media
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Labetalol
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lixisenatide
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
  • Macitentan
  • Maprotiline
  • Mecamylamine
  • Meglitinides
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methylphenidate
  • Methylprednisolone
  • Methysergide
  • Metolazone
  • Metoprolol
  • Midazolam
  • Midodrine
  • Miglitol
  • Mometasone
  • Monoamine oxidase inhibitors
  • Nabilone
  • Nadolol
  • Nafarelin
  • Naproxen; Pseudoephedrine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Non-Ionic Contrast Media
  • Oxazepam
  • Oxytocin
  • Ozanimod
  • Penbutolol
  • Pergolide
  • Perindopril; Amlodipine
  • Phendimetrazine
  • Phenelzine
  • Phenothiazines
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phosphodiesterase inhibitors
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium-sparing diuretics
  • Pramlintide
  • Prazosin
  • Prednisolone
  • Prednisone
  • Prilocaine; Epinephrine
  • Procarbazine
  • Propofol
  • Propranolol
  • Pseudoephedrine
  • Quazepam
  • Racepinephrine
  • Rasagiline
  • Reserpine
  • Riociguat
  • Rosiglitazone
  • Safinamide
  • Salmeterol
  • Selegiline
  • Selexipag
  • Semaglutide
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Solriamfetol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Tadalafil
  • Temazepam
  • Terazosin
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiothixene
  • Thyroid hormones
  • Timolol
  • Torsemide
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Umeclidinium; Vilanterol
  • Vardenafil
  • Vasodilators
  • Verapamil
  • Yohimbine
You cannot copy content of this page