Guaifenesin Pseudoephedrine

Guaifenesin Pseudoephedrine Brand Names

Aldex GS | Altarussin PE | Altex-PSE | Ambi | Ambifed | Ambifed-G | Ami-Tex PSE | Aquatab D | Coldmist JR | Coldmist LA | Coldmist S | Congestac | D Feda II | Decongest II | Deconsal II | Deconsal LA | Defen LA | Desal II | Drituss GP | Durasal II | Duratuss | Duratuss GP | Dynex | Entex PSE | Entex T | Eudal SR | ExeFen | ExeFen-IR | G Phed | G Phed PD | GP 500 | Guaidrine GP | Guaidrine PSE | Guaifed PD | Guaifen PSE | Guaifenex GP | Guaifenex PSE-120 | Guaifenex PSE-60 | Guaifenex PSE-80 | Guaifenex PSE-85 | Guaimax D | Guaipax PSE | Guai-Vent-PSE | Guiatex II SR | Iosal II | Iotex PSE | Levall G | Maxifed | Maxifed-G | Medent-LD | Medent-LDI | Mintab D | Miraphen PSE | Mucinex D | Nalex | Nalex JR | Nasatab LA | Nomuc-PE | PanMist JR | PanMist LA | PanMist S | Poly-Vent | Poly-Vent IR | Poly-Vent JR | Profen Forte | Profen II | Pseudatex | Pseudo GG TR | Pseudo Max | Pseudovent | Pseudovent-400 | Pseudovent-PED | Q-Tussin PE | Respa 1st | Respaire SR | Respaire-30 | Robitussin PE | Robitussin Severe Congestion | Ru-Tuss DE | Ru-Tuss Jr. | Sinutab | Stamoist E | Sudafed Non-Drying Sinus | Sudal SR | SudaTex | SudaTex-G | Touro LA | Touro LA-LD | Triaminic Chest and Nasal Congestion | Tusnel Pediatric | V Dec M | Versacaps | WE Mist II LA | WE Mist LA | Zephrex

What is Guaifenesin Pseudoephedrine

Guaifenesin and pseudoephedrine are used together in oral preparations.

Guaifenesin is an expectorant that loosens and thins sputum and bronchial secretions to ease expectoration; the drug has no antitussive activity.

Pseudoephedrine is a sympathomimetic decongestant agent that causes vasoconstriction and decreases nasal congestion.

Guaifenesin is used for dry, nonproductive cough when there is the presence of tenacious mucus and/or mucus plugs.

The results of a few studies have favored active treatment with guaifenesin over placebo in treating productive cough due to upper respiratory illness (URI).

In patients with chronic bronchitis, guaifenesin, is not recommended for aiding with cough suppression since studies have shown no benefit in reducing cough. However, the mucolytic properties of guaifenesin may be independently helpful in clearing mucus, and patients may subjectively report benefit to use.

Products containing guaifenesin; pseudoephedrine are primarily used for the temporary relief of congestion associated with the common cold and other upper respiratory conditions in adults and pediatric patients 6 years and older.

Indications

  1. common cold
  2. cough
  3. eustachian tube congestion
  4. nasal congestion
  5. sinusitis

For the treatment of cough and nasal congestion, including relief of eustachian tube congestion, associated with the common cold, sinusitis, or other upper respiratory conditions

Side Effects

  1. abdominal pain
  2. angina
  3. anorexia
  4. anxiety
  5. arrhythmia exacerbation
  6. colitis
  7. contact dermatitis
  8. diarrhea
  9. dizziness
  10. drowsiness
  11. dysuria
  12. erythema
  13. hallucinations
  14. headache
  15. hypertension
  16. insomnia
  17. myocardial infarction
  18. nausea
  19. nephrolithiasis
  20. ocular hypertension
  21. palpitations
  22. photophobia
  23. premature ventricular contractions (PVCs)
  24. psychosis
  25. rash
  26. restlessness
  27. seizures
  28. sinus tachycardia
  29. stroke
  30. supraventricular tachycardia (SVT)
  31. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • asthma
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • closed-angle glaucoma
  • coronary artery disease
  • diabetes mellitus
  • emphysema
  • fever
  • geriatric
  • heart failure
  • hypertension
  • hyperthyroidism
  • infants
  • MAOI therapy
  • myocardial infarction
  • peripheral vascular disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • tachycardia
  • tobacco smoking
  • urinary retention

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Aclidinium; Formoterol
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Arformoterol
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Budesonide; Formoterol
  • Bumetanide
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Clevidipine
  • Clonidine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Dorzolamide; Timolol
  • Dronabinol
  • Droxidopa
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esmolol
  • Ethacrynic Acid
  • Exenatide
  • Felodipine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Halogenated Anesthetics
  • Haloperidol
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Isocarboxazid
  • Isradipine
  • Labetalol
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lixisenatide
  • Loop diuretics
  • Macitentan
  • Maprotiline
  • Mecamylamine
  • Meglitinides
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methysergide
  • Metolazone
  • Metoprolol
  • Midodrine
  • Miglitol
  • Moexipril
  • Monoamine oxidase inhibitors
  • Nabilone
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Norepinephrine
  • Ozanimod
  • Penbutolol
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium-sparing diuretics
  • Pramlintide
  • Procarbazine
  • Propranolol
  • Quinapril
  • Racepinephrine
  • Ramipril
  • Rasagiline
  • Reserpine
  • Riociguat
  • Rosiglitazone
  • Safinamide
  • Salmeterol
  • Selegiline
  • Selexipag
  • Semaglutide
  • SGLT2 Inhibitors
  • Sibutramine
  • Solriamfetol
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Timolol
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Treprostinil
  • Tricyclic antidepressants
  • Umeclidinium; Vilanterol
  • Vasodilators
  • Vasopressors
  • Verapamil
  • Yohimbine
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