Guanabenz

Guanabenz Brand Name– Wytensin

What is Guanabenz

Guanabenz is a centrally active alpha-adrenergic agonist used to treat hypertension.

The drug is structurally and pharmacologically similar to clonidine and exerts comparable physiologic effects.

It is as effective in controlling blood pressure in hypertensive patients as other adrenergic inhibitors including methyldopa, clonidine, propranolol, or pindolol.

Guanabenz was approved for clinical use by the FDA in September 1982.

Indications

  • hypertension

Side Effects

  1. abdominal pain
  2. angina
  3. ataxia
  4. AV block
  5. blurred vision
  6. bradycardia
  7. constipation
  8. depression
  9. diaphoresis
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. dysgeusia
  14. dyspnea
  15. edema
  16. gynecomastia
  17. headache
  18. impotence (erectile dysfunction)
  19. increased urinary frequency
  20. insomnia
  21. libido decrease
  22. myalgia
  23. nasal congestion
  24. nausea
  25. palpitations
  26. pruritus
  27. rash
  28. tinnitus
  29. vomiting
  30. weakness
  31. withdrawal
  32. xerostomia

Monitoring Parameters

  • blood pressure

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • geriatric
  • hepatic disease
  • MAOI therapy
  • myocardial infarction
  • pregnancy

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alfentanil
  • Alprazolam
  • Alprostadil
  • Amifostine
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amyl Nitrite
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Baclofen
  • Belladonna; Opium
  • Bendroflumethiazide; Nadolol
  • Benzodiazepines
  • Benzphetamine
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bortezomib
  • Brexpiprazole
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Carbonic anhydrase inhibitors
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diethylpropion
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dobutamine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxepin
  • Duloxetine
  • Enflurane
  • Ephedrine
  • Epinephrine
  • Epoprostenol
  • Esmolol
  • Esomeprazole; Naproxen
  • Estazolam
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Etodolac
  • Etomidate
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
  • Fospropofol
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Imipramine
  • Indomethacin
  • Intravenous Lipid Emulsions
  • Isocarboxazid
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Ketamine
  • Ketoprofen
  • Ketorolac
  • Labetalol
  • Lansoprazole; Naproxen
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lofexidine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Lovastatin; Niacin
  • Lurasidone
  • Maprotiline
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Meperidine
  • Meperidine; Promethazine
  • Mepivacaine; Levonordefrin
  • Mesoridazine
  • Mestranol; Norethindrone
  • Methadone
  • Methamphetamine
  • Methazolamide
  • Methylphenidate
  • Metoprolol
  • Midazolam
  • Midodrine
  • Milrinone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabumetone
  • Nadolol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Norepinephrine
  • Nortriptyline
  • Olanzapine
  • Opiate Agonists
  • Oxaprozin
  • Oxazepam
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Paliperidone
  • Pemoline
  • Penbutolol
  • Pentoxifylline
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenothiazines
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Piroxicam
  • Prazosin
  • Prilocaine; Epinephrine
  • Procainamide
  • Procaine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Pseudoephedrine
  • Quazepam
  • Quinidine
  • Racepinephrine
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Ritodrine
  • Rofecoxib
  • Selegiline
  • Sevoflurane
  • Silodosin
  • Sotalol
  • Sufentanil
  • Sulindac
  • Sympathomimetics
  • Temazepam
  • Tetrabenazine
  • Tetracaine
  • Thiethylperazine
  • Thioridazine
  • Thiothixene
  • Timolol
  • Tizanidine
  • Tolmetin
  • Tranylcypromine
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Valdecoxib
  • Yohimbine
  • Ziprasidone