Guaifenesin Hydrocodone Pseudoephedrine

Guaifenesin Hydrocodone Pseudoephedrine Brand Names

C-Cof XP | ColdCough XP | Deconamine CX | Detussin Expectorant | Drituss HD | Duratuss HD | Dynex HD | Entex HC | Hycofenix | Hydro-Tussin HD | Hydro-Tussin XP | Hytussin Expectorant | Medtuss HD | Nalex Expectorant | Pancof XP | Poly-Tussin XP | Pseudatex HC | Spantuss HD | Su-Tuss HD | Tuss AX | Tussadur-HD | Tussend Expectorant | Vanacon | ZTuss

What is Guaifenesin Hydrocodone Pseudoephedrine

Guaifenesin Hydrocodone Pseudoephedrine products are used in an oral preparation to relieve cough, nasal congestion, and to loosen mucus associated with the common cold.

Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

Guaifenesin is an oral expectorant and is used to loosen and thin sputum and bronchial secretions and to ease expectoration.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Opioid cough and cold medicines that contain hydrocodone are not indicated for pediatric patients under 18 years of age.

The products are contraindicated in neonates, infants and children less than 6 years of age; the risks of these medicines outweigh their benefits in patients younger than 18 years.

Indications

• common cold
• cough
• nasal congestion

For relief of cough and nasal congestion due to the common cold or other acute upper respiratory infections

Side Effects

1. abdominal pain
2. anaphylactoid reactions
3. angina
4. anxiety
5. arrhythmia exacerbation
6. blurred vision
7. bowel ischemia
8. colitis
9. confusion
10. constipation
11. contact dermatitis
12. diarrhea
13. dizziness
14. drowsiness
15. dyspepsia
16. dysphoria
17. dyspnea
18. dysuria
19. emotional lability
20. erythema
21. euphoria
22. flushing
23. gastroesophageal reflux
24. headache
25. hot flashes
26. hyperhidrosis
27. hypotension
28. ileus
29. impaired cognition
30. increased intracranial pressure
31. insomnia
32. intracranial bleeding
33. irritability
34. lethargy
35. miosis
36. myocardial infarction
37. nausea
38. neonatal abstinence syndrome
39. nephrolithiasis
40. ocular hypertension
41. orthostatic hypotension
42. palpitations
43. photophobia
44. physiological dependence
45. pruritus
46. psychological dependence
47. rash
48. respiratory depression
49. restlessness
50. seizures
51. sinus tachycardia
52. stroke
53. syncope
54. tolerance
55. tremor
56. urinary retention
57. urticaria
58. vomiting
59. withdrawal
60. xerophthalmia
61. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• adrenal insufficiency
• angina
• anticholinergic medications
• asthma
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• children
• closed-angle glaucoma
• coadministration with other CNS depressants
• constipation
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• ethanol ingestion
• ethanol intoxication
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• intracranial mass
• labor
• MAOI therapy
• myocardial infarction
• neonates
• obstetric delivery
• opiate agonist hypersensitivity
• pheochromocytoma
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• respiratory depression
• substance abuse
• thyroid disease
• tobacco smoking
• urethral stricture
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetazolamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
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• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
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• Alprazolam
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Alvimopan
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• Amlodipine; Celecoxib
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• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
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• Amlodipine; Telmisartan
• Amlodipine; Valsartan
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• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbinoxamine
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• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
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• Castor Oil
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• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloral Hydrate
• Chloramphenicol
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
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• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clemastine
• Clevidipine
• Clobazam
• Clonazepam
• Clonidine
• Clopidogrel
• Clorazepate
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Conivaptan
• Crizotinib
• Crofelemer
• Cyclizine
• Cyclobenzaprine
• Cyclosporine
• Cyproheptadine
• Dabrafenib
• Dacomitinib
• Dalfopristin; Quinupristin
• Danazol
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
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• Darifenacin
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• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deferasirox
• Delavirdine
• Desflurane
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexpanthenol
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dolasetron
• Dopamine
• Dorzolamide; Timolol
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Droxidopa
• Dulaglutide
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• Duvelisib
• Dyphylline
• Dyphylline; Guaifenesin
• Efavirenz
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• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Eltrombopag
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Enzalutamide
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
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• Escitalopram
• Esketamine
• Eslicarbazepine
• Esmolol
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• Ethacrynic Acid
• Ethanol
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• Fenfluramine
• Fentanyl
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• Flibanserin
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Flutamide
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Fostamatinib
• Frovatriptan
• Furosemide
• Gabapentin
• General anesthetics
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Granisetron
• grapefruit juice
• Green Tea
• Guaifenesin; Phenylephrine
• Guanabenz
• Guanfacine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Homatropine; Hydrocodone
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Hydromorphone
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
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• Iloprost
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• Incretin Mimetics
• Indacaterol
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• Trihexyphenidyl
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vasodilators
• Vasopressors
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Voxelotor
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem