Griseofulvin

Griseofulvin Brand Names

Fulvicin P/G | Fulvicin U/F | Grifulvin V | Grisactin | Gris-Peg

What is Griseofulvin

Griseofulvin is an antifungal antibiotic produced by certain species of Penicillium.

The drug is used to treat tinea and other fungal infections, including onychomycosis.

Griseofulvin is marketed in several oral formulations in an attempt to increase bioavailability and decrease GI intolerance.

Griseofulvin microsize contains particles that are 4 micrometers in diameter, and ultramicrosize contains particles that are less than 1 micrometer in diameter.

Griseofulvin was isolated in 1939 and initially was used to treat ringworm in cattle.

Griseofulvin was not used extensively in humans until the late 1950s.

It was officially approved by the FDA in 1959.

Indications

  1. Epidermophyton floccosum
  2. Epidermophyton sp.
  3. Microsporum audouinii
  4. Microsporum canis
  5. Microsporum gypseum
  6. Microsporum sp.
  7. onychomycosis
  8. tinea barbae
  9. tinea capitis
  10. tinea corporis
  11. tinea cruris
  12. tinea pedis
  13. Trichophyton gallinae
  14. Trichophyton megninii
  15. Trichophyton mentagrophytes
  16. Trichophyton rubrum
  17. Trichophyton schoenleinii
  18. Trichophyton sp.
  19. Trichophyton tonsurans
  20. Trichophyton verrucosum

Side Effects

  1. abdominal pain
  2. angioedema
  3. candidiasis
  4. coagulopathy
  5. confusion
  6. diarrhea
  7. dizziness
  8. elevated hepatic enzymes
  9. erythema multiforme
  10. fatigue
  11. GI bleeding
  12. headache
  13. hepatitis
  14. hyperbilirubinemia
  15. insomnia
  16. jaundice
  17. leukopenia
  18. lupus-like symptoms
  19. nausea
  20. neutropenia
  21. paresthesias
  22. peripheral neuropathy
  23. photosensitivity
  24. proteinuria
  25. rash
  26. Stevens-Johnson syndrome
  27. teratogenesis
  28. toxic epidermal necrolysis
  29. urticaria
  30. vomiting

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN
  • urinalysis
  • WBC

Contraindications

  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • hepatic disease
  • new primary malignancy
  • penicillin hypersensitivity
  • porphyria
  • pregnancy
  • serious rash
  • sunlight (UV) exposure
  • systemic lupus erythematosus (SLE)

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Aminosalicylate sodium, Aminosalicylic acid
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Barbiturates
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Budesonide
  • Budesonide; Formoterol
  • Choline Salicylate; Magnesium Salicylate
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Cyclosporine
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • food
  • Halobetasol; Tazarotene
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Lopinavir; Ritonavir
  • Magnesium Salicylate
  • Mestranol; Norethindrone
  • Methoxsalen
  • Perampanel
  • Photosensitizing agents (topical)
  • Porfimer
  • Progestins
  • Rivaroxaban
  • Saccharomyces boulardii
  • Salicylates
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sulfonylureas
  • Tazarotene
  • Tretinoin, ATRA
  • Ulipristal
  • Verteporfin
  • Warfarin
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