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Griseofulvin Brand Names
Fulvicin P/G | Fulvicin U/F | Grifulvin V | Grisactin | Gris-Peg
What is Griseofulvin
Griseofulvin is an antifungal antibiotic produced by certain species of Penicillium.
The drug is used to treat tinea and other fungal infections, including onychomycosis.
Griseofulvin is marketed in several oral formulations in an attempt to increase bioavailability and decrease GI intolerance.
Griseofulvin microsize contains particles that are 4 micrometers in diameter, and ultramicrosize contains particles that are less than 1 micrometer in diameter.
Griseofulvin was isolated in 1939 and initially was used to treat ringworm in cattle.
Griseofulvin was not used extensively in humans until the late 1950s.
It was officially approved by the FDA in 1959.
Indications
- Epidermophyton floccosum
- Epidermophyton sp.
- Microsporum audouinii
- Microsporum canis
- Microsporum gypseum
- Microsporum sp.
- onychomycosis
- tinea barbae
- tinea capitis
- tinea corporis
- tinea cruris
- tinea pedis
- Trichophyton gallinae
- Trichophyton megninii
- Trichophyton mentagrophytes
- Trichophyton rubrum
- Trichophyton schoenleinii
- Trichophyton sp.
- Trichophyton tonsurans
- Trichophyton verrucosum
Side Effects
- abdominal pain
- angioedema
- candidiasis
- coagulopathy
- confusion
- diarrhea
- dizziness
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- GI bleeding
- headache
- hepatitis
- hyperbilirubinemia
- insomnia
- jaundice
- leukopenia
- lupus-like symptoms
- nausea
- neutropenia
- paresthesias
- peripheral neuropathy
- photosensitivity
- proteinuria
- rash
- Stevens-Johnson syndrome
- teratogenesis
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- urinalysis
- WBC
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- hepatic disease
- new primary malignancy
- penicillin hypersensitivity
- porphyria
- pregnancy
- serious rash
- sunlight (UV) exposure
- systemic lupus erythematosus (SLE)
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Aminosalicylate sodium, Aminosalicylic acid
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Barbiturates
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide
- Budesonide; Formoterol
- Choline Salicylate; Magnesium Salicylate
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Cyclosporine
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- food
- Halobetasol; Tazarotene
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Lopinavir; Ritonavir
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methoxsalen
- Perampanel
- Photosensitizing agents (topical)
- Porfimer
- Progestins
- Rivaroxaban
- Saccharomyces boulardii
- Salicylates
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sulfonylureas
- Tazarotene
- Tretinoin, ATRA
- Ulipristal
- Verteporfin
- Warfarin