Aminolevulinic Acid

Aminolevulinic Acid Brand Names- Ameluz | Gleolan | Levulan Kerastick

What is Aminolevulinic Acid

Aminolevulinic acid is an endogenous 5-carbon aminoketone and a precursor to the photosensitizing compound, protoporphyrin IX (PpIX). PpIX is a potent photosensitizer that produces a high fluorescent yield.

Aminolevulinic acid is commercially available as oral and topical formulations. The oral formulation is approved for use during surgery in patients with glioma (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for visualization of malignant tissue.

The topical formulations (i.e., 20% topical solution and 10% topical gel) are indicated for use with either a BLU-U (blue light illuminator) or BF-RhodoLED (red light illuminator) photodynamic therapy lamp, respectively, to treat minimally to moderately severe actinic keratosis of the face and scalp.

The 20% topical solution and blue light illuminator is also approved to treat actinic keratosis of the upper extremities.

Indications

  1. actinic keratosis
  2. Barrett’s esophagus
  3. basal cell carcinoma
  4. head and neck cancer
  5. malignant glioma

For the treatment of minimally to moderately severe actinic keratosis

for the treatment of actinic keratosis lesions of the scalp or face

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • breast-feeding
  • coagulopathy
  • inflammation
  • ocular exposure
  • porphyria
  • porphyrin hypersensitivity
  • pregnancy
  • requires an experienced clinician
  • skin photosensitivity disorder
  • sunlight (UV) exposure

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acitretin
  • Adapalene
  • Adapalene; Benzoyl Peroxide
  • Alteplase
  • Aminosalicylate sodium, Aminosalicylic acid
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bexarotene
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Calcium-channel blockers
  • Choline Salicylate; Magnesium Salicylate
  • Corticosteroids
  • Demeclocycline
  • Doxycycline
  • Eravacycline
  • Erythromycin; Sulfisoxazole
  • Griseofulvin
  • Halobetasol; Tazarotene
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indapamide
  • Magnesium Salicylate
  • Methotrexate
  • Minocycline
  • Nonsteroidal antiinflammatory drugs
  • Omadacycline
  • Phenothiazines
  • Platelet Inhibitors
  • Porfimer
  • Pyrimethamine; Sulfadoxine
  • Reteplase, r-PA
  • Salicylates
  • Salsalate
  • Sarecycline
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sulfacetamide
  • Sulfacetamide; Sulfur
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Sulfonylureas
  • Tazarotene
  • Tenecteplase
  • Tetracycline
  • Tetracyclines
  • Thiazide diuretics
  • Thiothixene
  • Thrombolytic Agents
  • Tretinoin, ATRA
  • Trifarotene
  • Urokinase
  • Verteporfin
  • Ziprasidone
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