Ascorbic Acid Vitamin C

Ascorbic Acid Brand Names

Acerola C | Ascor | Ascor L-500 | Betac | Cecon | Cenolate

What is Ascorbic Acid

Ascorbic acid (vitamin C, sodium ascorbate, ascorbate) is a water-soluble vitamin found in fruits and vegetables such as citrus fruits and green peppers.

Ascorbic acid is a free radical, an antioxidant scavenger, and plays a major role in oxidation-reduction reactions.

Ascorbic acid is a cofactor for enzymes involved in the biosynthesis of collagen (essential for tissue maintenance and repair), carnitine, and neurotransmitters. Humans cannot synthesize ascorbic acid endogenously and a lack of dietary intake can lead to scurvy.

Intravenous ascorbic acid is FDA-approved for the treatment of scurvy.

Vitamin C is also most frequently used as a nutritional supplement and as an adjunct in wound healing.

It also is used as a treatment of methemoglobinemia as an alternative in patients who cannot receive methylene blue and with deferoxamine in the treatment of chronic iron toxicity.

Vitamin C deficiency is highly prevalent during critical illness and high-dose vitamin C has been used in patients with sepsis, trauma, and burns with beneficial effects and no adverse effects.

Ascorbic acid has also been used for a variety of ailments including the common cold, gum infections, acne, depression, fertility, and cancer; however, these claims have not been substantiated and vitamin C is not recommended for these purposes. 

Indications

  1. burns
  2. decubitus ulcer
  3. furunculosis
  4. iron toxicity
  5. methemoglobinemia
  6. nutritional supplementation
  7. scurvy
  8. urinary acidification
  9. wound management

Side Effects

  1. back pain
  2. costovertebral pain
  3. dental caries
  4. diarrhea
  5. dizziness
  6. flushing
  7. headache
  8. hemolysis
  9. hemolytic anemia
  10. hyperoxaluria
  11. injection site reaction
  12. lethargy
  13. nausea
  14. nephrolithiasis
  15. renal tubular obstruction
  16. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • G6PD deficiency
  • geriatric
  • hemochromatosis
  • hemolysis
  • hemolytic anemia
  • infants
  • laboratory test interference
  • nephrolithiasis
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • sodium restriction

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amphetamines
  • Antacids
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bleomycin
  • Calcium Carbonate; Magnesium Hydroxide
  • Choline Salicylate; Magnesium Salicylate
  • Colesevelam
  • Deferoxamine
  • Disulfiram
  • Doxycycline
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fluphenazine
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Kanamycin
  • Lincomycin
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Mexiletine
  • Omeprazole; Sodium Bicarbonate
  • Propranolol
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Streptomycin
  • Warfarin
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