Glycopyrronium

Glycopyrronium Brand Name– Qbrexza

What is Glycopyrronium

Glycopyrronium is an anticholinergic agent indicated for topical treatment of primary axillary hyperhidrosis in adults and pediatric patients 9 years of age and older.

The product is available as a pre-moistened cloth that should be apply no more frequently than once every 24 hours. Patients who apply the drug in the presence of high ambient temperature may be at increased risk for heat illness (e.g., hyperpyrexia, heat stroke).

Instruct drug recipients to watch for a generalized lack of sweating when in hot or very warm environments, and to avoid use if not sweating in these conditions. Use of the drug should also be avoided in patients with medical conditions that may be exacerbated by the anticholinergic actions of glycopyrronium.

Indications

  • hyperhidrosis

For the treatment of primary axillary hyperhidrosis

Side Effects

  1. blurred vision
  2. constipation
  3. contact dermatitis
  4. erythema
  5. headache
  6. mydriasis
  7. nasal dryness
  8. pharyngitis
  9. pruritus
  10. rash
  11. skin irritation
  12. urinary retention
  13. xerophthalmia
  14. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • ambient temperature increase
  • anticholinergic medications
  • breast-feeding
  • cardiac arrhythmias
  • contact lenses
  • coronary artery disease
  • driving or operating machinery
  • glaucoma
  • heart failure
  • hemorrhagic shock
  • hypertension
  • ileus
  • myasthenia gravis
  • pregnancy
  • prostatic hypertrophy
  • Sjogren’s syndrome
  • tachycardia
  • toxic megacolon
  • ulcerative colitis
  • urinary retention
  • urinary tract obstruction

Interactions

  • Albuterol; Ipratropium
  • Anticholinergics
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Chlordiazepoxide; Clidinium
  • Dicyclomine
  • Flavoxate
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Homatropine; Hydrocodone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indacaterol; Glycopyrrolate
  • Ipratropium
  • Mepenzolate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Oxybutynin
  • Propantheline
  • Scopolamine
  • Solifenacin
  • Tolterodine
  • Trihexyphenidyl
  • Trospium