Ertapenem

Ertapenem Brand Name– Invanz

What is Ertapenem

Ertapenem is a 1-beta methyl carbapenem, structurally related to beta-lactam antibiotics.

It is highly stable against beta-lactamases and has activity against a wide variety of gram-positive, gram-negative and anaerobic microorganisms, but has no activity against Pseudomonas aeruginosa. 

Ertapenem is administered parenterally once daily for complicated urinary tract infections, skin and skin-structure infections, acute pelvic infections, community-acquired pneumonia, and intraabdominal infections. It is also used for surgical prophylaxis in colorectal procedures.

The FDA approved ertapenem in November 2001.

Indications

  1. bacteremia
  2. Bacteroides fragilis
  3. Bacteroides ovatus
  4. Bacteroides thetaiotaomicron
  5. Bacteroides uniformis
  6. Bacteroides vulgatus
  7. Citrobacter freundii
  8. Citrobacter koseri
  9. Clostridium clostridioforme
  10. Clostridium perfringens
  11. community-acquired pneumonia
  12. diabetic foot ulcer
  13. Eggerthella lenta
  14. endomyometritis
  15. Enterobacter cloacae
  16. Escherichia coli
  17. Fusobacterium sp.
  18. gynecologic infections
  19. Haemophilus influenzae (beta-lactamase negative)
  20. Haemophilus influenzae (beta-lactamase positive)
  21. Haemophilus parainfluenzae
  22. intraabdominal infections
  23. Klebsiella aerogenes
  24. Klebsiella oxytoca
  25. Klebsiella pneumoniae
  26. Moraxella catarrhalis
  27. Morganella morganii
  28. Parabacteroides distasonis
  29. Peptostreptococcus sp.
  30. pneumonia
  31. Porphyromonas asaccharolytica
  32. Prevotella bivia
  33. Proteus mirabilis
  34. Proteus vulgaris
  35. Providencia rettgeri
  36. Providencia stuartii
  37. pyelonephritis
  38. Serratia marcescens
  39. skin and skin structure infections
  40. Staphylococcus aureus (MSSA)
  41. Staphylococcus epidermidis
  42. Streptococcus agalactiae (group B streptococci)
  43. Streptococcus pneumoniae
  44. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  45. surgical infection prophylaxis
  46. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agitation
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. anorexia
  8. anuria
  9. anxiety
  10. arthralgia
  11. asthenia
  12. asystole
  13. atrial fibrillation
  14. azotemia
  15. bleeding
  16. bradycardia
  17. candidiasis
  18. cardiac arrest
  19. chest pain (unspecified)
  20. chills
  21. cholelithiasis
  22. confusion
  23. constipation
  24. cough
  25. delirium
  26. depression
  27. diarrhea
  28. dizziness
  29. drowsiness
  30. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  31. dysgeusia
  32. dyskinesia
  33. dyspepsia
  34. dysphagia
  35. dyspnea
  36. dysuria
  37. edema
  38. elevated hepatic enzymes
  39. epistaxis
  40. erythema
  41. esophagitis
  42. fatigue
  43. fever
  44. flank pain
  45. flatulence
  46. flushing
  47. gastritis
  48. GI bleeding
  49. GI obstruction
  50. gout
  51. hallucinations
  52. headache
  53. heart failure
  54. hematoma
  55. hematuria
  56. hemoptysis
  57. hemorrhoids
  58. hiccups
  59. hyperbilirubinemia
  60. hyperglycemia
  61. hyperhidrosis
  62. hyperkalemia
  63. hypernatremia
  64. hypertension
  65. hypoesthesia
  66. hypokalemia
  67. hypotension
  68. hypothermia
  69. ileus
  70. increased urinary frequency
  71. infection
  72. injection site reaction
  73. insomnia
  74. jaundice
  75. malaise
  76. myoclonia
  77. nausea
  78. oliguria
  79. oral ulceration
  80. pancreatitis
  81. paresthesias
  82. pharyngitis
  83. phlebitis
  84. pleural effusion
  85. pruritus
  86. pseudomembranous colitis
  87. pulmonary embolism
  88. pyloric stenosis
  89. rash
  90. rhinitis
  91. rhinorrhea
  92. seizures
  93. sinus tachycardia
  94. stomatitis
  95. stroke
  96. superinfection
  97. syncope
  98. tooth discoloration
  99. tremor
  100. urinary retention
  101. urticaria
  102. vaginitis
  103. ventricular tachycardia
  104. vertigo
  105. vomiting
  106. weight loss
  107. wheezing
  108. wound dehiscence
  109. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • amide local anesthetic hypersensitivity
  • brain tumor
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • colitis
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • myoclonic seizures
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • seizures
  • ulcerative colitis
  • viral infection

Interactions

  • Colchicine; Probenecid
  • Oral Contraceptives
  • Probenecid
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Valproic Acid, Divalproex Sodium
  • Warfarin
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