Ertapenem Brand Name– Invanz
What is Ertapenem
Ertapenem is a 1-beta methyl carbapenem, structurally related to beta-lactam antibiotics.
It is highly stable against beta-lactamases and has activity against a wide variety of gram-positive, gram-negative and anaerobic microorganisms, but has no activity against Pseudomonas aeruginosa.
Ertapenem is administered parenterally once daily for complicated urinary tract infections, skin and skin-structure infections, acute pelvic infections, community-acquired pneumonia, and intraabdominal infections. It is also used for surgical prophylaxis in colorectal procedures.
The FDA approved ertapenem in November 2001.
Indications
- bacteremia
- Bacteroides fragilis
- Bacteroides ovatus
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Citrobacter koseri
- Clostridium clostridioforme
- Clostridium perfringens
- community-acquired pneumonia
- diabetic foot ulcer
- Eggerthella lenta
- endomyometritis
- Enterobacter cloacae
- Escherichia coli
- Fusobacterium sp.
- gynecologic infections
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Moraxella catarrhalis
- Morganella morganii
- Parabacteroides distasonis
- Peptostreptococcus sp.
- pneumonia
- Porphyromonas asaccharolytica
- Prevotella bivia
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- pyelonephritis
- Serratia marcescens
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- surgical infection prophylaxis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anuria
- anxiety
- arthralgia
- asthenia
- asystole
- atrial fibrillation
- azotemia
- bleeding
- bradycardia
- candidiasis
- cardiac arrest
- chest pain (unspecified)
- chills
- cholelithiasis
- confusion
- constipation
- cough
- delirium
- depression
- diarrhea
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyskinesia
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- epistaxis
- erythema
- esophagitis
- fatigue
- fever
- flank pain
- flatulence
- flushing
- gastritis
- GI bleeding
- GI obstruction
- gout
- hallucinations
- headache
- heart failure
- hematoma
- hematuria
- hemoptysis
- hemorrhoids
- hiccups
- hyperbilirubinemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypernatremia
- hypertension
- hypoesthesia
- hypokalemia
- hypotension
- hypothermia
- ileus
- increased urinary frequency
- infection
- injection site reaction
- insomnia
- jaundice
- malaise
- myoclonia
- nausea
- oliguria
- oral ulceration
- pancreatitis
- paresthesias
- pharyngitis
- phlebitis
- pleural effusion
- pruritus
- pseudomembranous colitis
- pulmonary embolism
- pyloric stenosis
- rash
- rhinitis
- rhinorrhea
- seizures
- sinus tachycardia
- stomatitis
- stroke
- superinfection
- syncope
- tooth discoloration
- tremor
- urinary retention
- urticaria
- vaginitis
- ventricular tachycardia
- vertigo
- vomiting
- weight loss
- wheezing
- wound dehiscence
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- amide local anesthetic hypersensitivity
- brain tumor
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- dialysis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- myoclonic seizures
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizures
- ulcerative colitis
- viral infection
Interactions
- Colchicine; Probenecid
- Oral Contraceptives
- Probenecid
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Valproic Acid, Divalproex Sodium
- Warfarin