Ertugliflozin

Ertugliflozin Brand Name– STEGLATRO

What is Ertugliflozin

Ertugliflozin is an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor.

Ertugliflozin works by blocking the reabsorption of glucose by the kidney, which results in increased glucose excretion and reduced blood glucose concentrations.

Ertugliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (DM). Ertugliflozin monotherapy reduced A1C by 0.8 to 1% during clinical trials. The drug is not recommended for use in patients with severe renal impairment, as drug efficacy is reduced and the risk for renal-related adverse events may be increased.

SGLT2 inhibitor therapy has been shown to reduce the incidence of heart failure (HF), and some SGLT2 inhibitors have reduced overall cardiovascular (CV) risk.

Metformin is first-line in the treatment of type 2 DM.

Additional therapy with an SGLT2 inhibitor with evidence of reducing HF and/or chronic kidney disease (CKD) progression should be considered in patients with indicators of high-risk or established CKD or HF, independent of baseline A1C or individualized A1C target.

SGLT2 inhibitors with proven CV-risk reduction are also an alternative treatment option in DM patients with indicators of high-risk or established CV disease who cannot tolerate a glucagon-like peptide-1 receptor agonist (GLP-1 RA).

Indications

  • type 2 diabetes mellitus

For the treatment of type 2 diabetes mellitus in combination with diet and exercise

Side Effects

  1. back pain
  2. balanitis
  3. candidiasis
  4. cystitis
  5. dehydration
  6. diabetic ketoacidosis
  7. diuresis
  8. dysuria
  9. headache
  10. hypercholesterolemia
  11. hyperlipidemia
  12. hyperphosphatemia
  13. hypoglycemia
  14. hypotension
  15. hypovolemia
  16. increased urinary frequency
  17. infection
  18. lower limb amputation
  19. necrotizing fasciitis
  20. nocturia
  21. orthostatic hypotension
  22. pharyngitis
  23. phimosis
  24. polydipsia
  25. polyuria
  26. renal failure (unspecified)
  27. syncope
  28. tissue necrosis
  29. urinary urgency
  30. vaginitis
  31. weight loss

Monitoring Parameters

  • blood glucose
  • glycosylated hemoglobin A1c (HbA1c)
  • serum cholesterol profile
  • serum creatinine/BUN

Contraindications

  • adrenal insufficiency
  • balanitis
  • breast-feeding
  • burns
  • children
  • dehydration
  • diabetic ketoacidosis
  • dialysis
  • fever
  • geriatric
  • hepatic disease
  • hypercholesterolemia
  • hypercortisolism
  • hyperglycemia
  • hyperthyroidism
  • hypoglycemia
  • hypotension
  • hypothyroidism
  • hypovolemia
  • infants
  • infection
  • lower limb amputation
  • malnutrition
  • pituitary insufficiency
  • pregnancy
  • pyelonephritis
  • renal disease
  • renal failure
  • renal impairment
  • surgery
  • tissue necrosis
  • trauma
  • type 1 diabetes mellitus
  • urinary tract infection (UTI)
  • vaginitis

Interactions

  • Acebutolol
  • Acetazolamide
  • Aliskiren; Valsartan
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Androgens
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Atenolol
  • Atenolol; Chlorthalidone
  • atypical antipsychotic
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bortezomib
  • Brimonidine; Timolol
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbonic anhydrase inhibitors
  • Carteolol
  • Carvedilol
  • Chloroquine
  • Chlorthalidone; Clonidine
  • Chromium
  • Clarithromycin
  • Clonidine
  • Corticosteroids
  • Daclatasvir
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Diazoxide
  • Dorzolamide; Timolol
  • Elbasvir; Grazoprevir
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esmolol
  • Estrogens
  • Ethanol
  • Fibric acid derivatives
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Garlic, Allium sativum
  • Glecaprevir; Pibrentasvir
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydroxychloroquine
  • Irbesartan
  • Isocarboxazid
  • Labetalol
  • Lanreotide
  • Ledipasvir; Sofosbuvir
  • Levobetaxolol
  • Levobunolol
  • Lisinopril
  • Lomefloxacin
  • Losartan
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Methazolamide
  • Metoprolol
  • Moexipril
  • Monoamine oxidase inhibitors
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Octreotide
  • Olmesartan
  • Orlistat
  • Pasireotide
  • Pegvisomant
  • Penbutolol
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenothiazines
  • Pindolol
  • Propranolol
  • Quinapril
  • Quinolones
  • Ramipril
  • Sacubitril; Valsartan
  • Selegiline
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Somatropin, rh-GH
  • Sotalol
  • Sparfloxacin
  • Sulfonamides
  • Sympathomimetics
  • Telmisartan
  • Timolol
  • tobacco
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trovafloxacin, Alatrofloxacin
  • Valsartan
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