Erlotinib Brand Name– Tarceva
What is Erlotinib
Erlotinib is an oral, selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that is FDA-approved as monotherapy for the treatment of metastatic non-small cell lung cancer (NSCLC) in patients with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations and in combination with gemcitabine for the treatment of locally advanced, unresectable, or metastatic pancreatic cancer.
EGFR is expressed, overexpressed, or dysregulated in many cancers; clinically,
EGFR expression has been associated with poor prognosis, development of metastasis, and resistance to chemotherapy, hormonal therapy, and radiation therapy.
Indications
- head and neck cancer
- non-small cell lung cancer (NSCLC)
- pancreatic cancer
For the treatment of non-small cell lung cancer (NSCLC)
for the first-line treatment of metastatic NSCLC in patients whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations, in combination with ramucirumab
Side Effects
- acneiform rash
- anorexia
- anorexia
- arrhythmia exacerbation
- arthralgia
- arthralgia
- asthenia
- back pain
- back pain
- bullous rash
- chest pain (unspecified)
- chest pain (unspecified)
- colitis
- conjunctivitis
- conjunctivitis
- cough
- cough
- dehydration
- depression
- depression
- diarrhea
- diarrhea
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- folliculitis
- gastritis
- GI bleeding
- GI perforation
- headache
- headache
- hematemesis
- hemolytic anemia
- hepatic failure
- hepatotoxicity
- hyperbilirubinemia
- hyperbilirubinemia
- hypertrichosis
- ileus
- infection
- infection
- keratitis
- keratoconjunctivitis
- lacrimation
- maculopapular rash
- melena
- musculoskeletal pain
- musculoskeletal pain
- myocardial infarction
- myopathy
- nausea
- nausea
- ocular inflammation
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- peptic ulcer
- photosensitivity
- pneumonitis
- prolonged bleeding time
- pruritus
- pruritus
- rash
- rash
- renal failure (unspecified)
- rhabdomyolysis
- skin hyperpigmentation
- skin ulcer
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- thrombosis
- toxic epidermal necrolysis
- uveitis
- weight loss
- weight loss
- xerosis
- xerosis
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum electrolytes
Contraindications
- biliary obstruction
- breast-feeding
- chronic lung disease (CLD)
- contraception requirements
- corticosteroid therapy
- dehydration
- diverticulitis
- GI perforation
- hepatic disease
- hepatotoxicity
- keratitis
- ocular disease
- peptic ulcer disease
- pneumonitis
- pregnancy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- reproductive risk
- tobacco smoking
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Apalutamide
- Armodafinil
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Cabazitaxel
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbamazepine
- Celecoxib
- Cenobamate
- Ceritinib
- Chloramphenicol
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Cortisone
- Dabrafenib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Dexamethasone
- Dexlansoprazole
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Docetaxel
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Etodolac
- Etravirine
- Famotidine
- Famotidine; Ibuprofen
- Fenoprofen
- Fludrocortisone
- Flurbiprofen
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Indinavir
- Indomethacin
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole
- Lansoprazole; Naproxen
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumateperone
- Magnesium Hydroxide
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mephobarbital
- Methohexital
- Methylprednisolone
- Mifepristone
- Mitotane
- Modafinil
- Nabumetone
- Nafcillin
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nefazodone
- Nelfinavir
- Nevirapine
- Nilotinib
- Nizatidine
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Osilodrostat
- Oxaprozin
- Oxcarbazepine
- Paclitaxel
- Pantoprazole
- Pentobarbital
- Pexidartinib
- Phenobarbital
- Phenytoin
- Piroxicam
- Posaconazole
- Prednisolone
- Prednisone
- Primidone
- Quinine
- Rabeprazole
- Ranitidine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rofecoxib
- Saquinavir
- Secobarbital
- Simeprevir
- Sodium Bicarbonate
- St. John’s Wort, Hypericum perforatum
- Sulindac
- Taxanes
- Telithromycin
- Thiopental
- Tipranavir
- tobacco
- Tolmetin
- Trandolapril; Verapamil
- Triamcinolone
- Tucatinib
- Valdecoxib
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast