Cephradine Brand Name– Velosef
What is Cephradine
Cephradine is an oral first-generation cephalosporin antibiotic similar in structure and activity to cephalexin. The in vitro antibacterial activity of cephradine includes excellent gram-positive but limited gram-negative coverage.
Cephradine is indicated for the treatment of urinary tract infections, skin and skin structure infections, respiratory tract infections, and otitis media.
Cephradine has been administered parenterally, however, the parenteral product is no longer available in the United States.
This drug was approved by the FDA in 1965.
Indications
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Klebsiella sp.
- otitis media
- pharyngitis
- pneumonia
- prostatitis
- Proteus mirabilis
- skin and skin structure infections
- Staphylococcus sp.
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- surgical infection prophylaxis
- tonsillitis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arthralgia
- azotemia
- chills
- diarrhea
- dizziness
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema
- erythema multiforme
- exfoliative dermatitis
- fever
- hypoprothrombinemia
- hypotension
- leukopenia
- maculopapular rash
- nausea
- neutropenia
- pruritus
- pruritus ani
- pseudomembranous colitis
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- diarrhea
- geriatric
- GI disease
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
- vitamin K deficiency
Interactions
- Loop diuretics
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
