Cephradine

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Cephradine Brand Name– Velosef

What is Cephradine

Cephradine is an oral first-generation cephalosporin antibiotic similar in structure and activity to cephalexin. The in vitro antibacterial activity of cephradine includes excellent gram-positive but limited gram-negative coverage.

Cephradine is indicated for the treatment of urinary tract infections, skin and skin structure infections, respiratory tract infections, and otitis media.

Cephradine has been administered parenterally, however, the parenteral product is no longer available in the United States.

This drug was approved by the FDA in 1965.

Indications

  1. Escherichia coli
  2. Haemophilus influenzae (beta-lactamase negative)
  3. Klebsiella sp.
  4. otitis media
  5. pharyngitis
  6. pneumonia
  7. prostatitis
  8. Proteus mirabilis
  9. skin and skin structure infections
  10. Staphylococcus sp.
  11. Streptococcus pneumoniae
  12. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  13. surgical infection prophylaxis
  14. tonsillitis
  15. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. arthralgia
  7. azotemia
  8. chills
  9. diarrhea
  10. dizziness
  11. edema
  12. elevated hepatic enzymes
  13. eosinophilia
  14. erythema
  15. erythema multiforme
  16. exfoliative dermatitis
  17. fever
  18. hypoprothrombinemia
  19. hypotension
  20. leukopenia
  21. maculopapular rash
  22. nausea
  23. neutropenia
  24. pruritus
  25. pruritus ani
  26. pseudomembranous colitis
  27. seizures
  28. serum sickness
  29. Stevens-Johnson syndrome
  30. superinfection
  31. toxic epidermal necrolysis
  32. urticaria
  33. vaginitis
  34. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • inflammatory bowel disease
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Loop diuretics
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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