Enzalutamide Brand Name– XTANDI
What is Enzalutamide
Enzalutamide is an androgen receptor inhibitor. It works by competitively inhibiting androgen binding to androgen receptors, thus inhibiting nuclear translocation of androgen receptors and their interaction with DNA.
It is indicated for the treatment of castration-resistant prostate cancer (CRPC), where it significantly prolonged metastasis-free survival in patients with non-metastatic disease, and significantly prolonged overall survival in both chemotherapy naive and previously treated metastatic CRPC.
Seizures have been reported with therapy; patients should be aware of the risk of engaging in any activity where sudden loss of consciousness could seriously harm themselves or others
Indications
- prostate cancer
For the treatment of prostate cancer
for the treatment of metastatic, hormone-sensitive prostate cancer
Side Effects
- amnesia
- angioedema
- anorexia
- anorexia
- anxiety
- anxiety
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- bone fractures
- bone fractures
- constipation
- constipation
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dysgeusia
- dyspnea
- dyspnea
- edema
- encephalopathy
- epistaxis
- epistaxis
- fatigue
- fatigue
- gynecomastia
- headache
- headache
- hematuria
- hematuria
- hot flashes
- hot flashes
- hypercalcemia
- hypercalcemia
- hyperglycemia
- hyperglycemia
- hypermagnesemia
- hypermagnesemia
- hypertension
- hypertension
- hypoesthesia
- hypoesthesia
- hyponatremia
- hyponatremia
- impaired cognition
- increased urinary frequency
- infection
- infection
- insomnia
- insomnia
- laryngitis
- leukopenia
- leukopenia
- memory impairment
- musculoskeletal pain
- musculoskeletal pain
- nausea
- nausea
- neutropenia
- neutropenia
- paresthesias
- peripheral edema
- peripheral edema
- pharyngitis
- pruritus
- rash
- restless legs syndrome (RLS)
- restless legs syndrome (RLS)
- rhinitis
- seizures
- sinusitis
- spinal cord compression
- vertigo
- vomiting
- weakness
- weakness
- weight loss
- weight loss
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- angioedema
- bone fractures
- brain tumor
- breast-feeding
- cardiac disease
- contraception requirements
- diabetes mellitus
- driving or operating machinery
- encephalopathy
- females
- head trauma
- hyperlipidemia
- hypertension
- infertility
- male-mediated teratogenicity
- pregnancy
- reproductive risk
- seizures
- stroke
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Abiraterone
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alpelisib
- Alprazolam
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apremilast
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
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- Atazanavir; Cobicistat
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