Apalutamide

Apalutamide Brand Name– ERLEADA

What is Apalutamide

Apalutamide is an androgen receptor inhibitor approved for the treatment of patients with nonmetastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer.

Patients treated with apalutamide experienced more falls and fractures in clinical trials than patients who received placebo; patients should be evaluated for risk and treated with bone-targeting agents as appropriate.

Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions prior to administration.

Indications

  • prostate cancer

For the treatment of prostate cancer

for the treatment of nonmetastatic castration-resistant prostate cancer

Side Effects

  1. anemia
  2. anorexia
  3. arthralgia
  4. asthenia
  5. bone fractures
  6. cardiac arrest
  7. conjunctivitis
  8. diarrhea
  9. dysgeusia
  10. edema
  11. erythema multiforme
  12. exfoliative dermatitis
  13. fatigue
  14. GI perforation
  15. heart failure
  16. hematuria
  17. hot flashes
  18. hypercholesterolemia
  19. hyperglycemia
  20. hyperkalemia
  21. hypertension
  22. hypertriglyceridemia
  23. hypothyroidism
  24. infection
  25. intracranial bleeding
  26. leukopenia
  27. lymphopenia
  28. maculopapular rash
  29. muscle cramps
  30. myocardial infarction
  31. nausea
  32. nephrotoxicity
  33. oral ulceration
  34. penile edema
  35. peripheral edema
  36. pruritus
  37. QT prolongation
  38. rash
  39. respiratory arrest
  40. seizures
  41. skin erosion
  42. stomatitis
  43. stroke
  44. urticaria
  45. vesicular rash
  46. weight loss

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • angina
  • bone fractures
  • breast-feeding
  • contraception requirements
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • heart failure
  • hyperlipidemia
  • hypertension
  • infertility
  • male-mediated teratogenicity
  • myocardial infarction
  • pregnancy
  • reproductive risk
  • seizure disorder
  • seizures

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abemaciclib
  • Abiraterone
  • Acalabrutinib
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Afatinib
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alpelisib
  • Alprazolam
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apixaban
  • Apremilast
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Avanafil
  • Avapritinib
  • Axitinib
  • Bedaquiline
  • Benzhydrocodone; Acetaminophen
  • Betrixaban
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bortezomib
  • Bosutinib
  • Brentuximab vedotin
  • Brexpiprazole
  • Brigatinib
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Cabozantinib
  • Canagliflozin
  • Canagliflozin; Metformin
  • Cannabidiol
  • Capmatinib
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Carvedilol
  • Celecoxib
  • Ceritinib
  • Cevimeline
  • Chloramphenicol
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clonazepam
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Conjugated Estrogens; Medroxyprogesterone
  • Copanlisib
  • Crizotinib
  • Cyclosporine
  • Dabigatran
  • Daclatasvir
  • Dapagliflozin; Saxagliptin
  • Dapsone
  • Darifenacin
  • Darolutamide
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Deferasirox
  • Deflazacort
  • Delavirdine
  • Dexamethasone
  • Dexlansoprazole
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Docetaxel
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duvelisib
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elexacaftor; tezacaftor; ivacaftor
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encorafenib
  • Entrectinib
  • Eravacycline
  • Erdafitinib
  • Erlotinib
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Eszopiclone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etonogestrel
  • Etravirine
  • Everolimus
  • Exemestane
  • Fedratinib
  • Felodipine
  • Fentanyl
  • Flibanserin
  • Flurazepam
  • Fosamprenavir
  • Fostamatinib
  • Gefitinib
  • Gemfibrozil
  • Gilteritinib
  • Glasdegib
  • Glecaprevir; Pibrentasvir
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glyburide
  • Glyburide; Metformin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyprogesterone
  • Ibrutinib
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Ifosfamide
  • Imatinib
  • Imipramine
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indinavir
  • Irinotecan
  • Irinotecan Liposomal
  • Isavuconazonium
  • Isradipine
  • Istradefylline
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ixazomib
  • Ketoconazole
  • Lamotrigine
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lapatinib
  • Larotrectinib
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lemborexant
  • Letermovir
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Macimorelin
  • Macitentan
  • Maraviroc
  • Medroxyprogesterone
  • Mefloquine
  • Mestranol; Norethindrone
  • Metformin; Repaglinide
  • Metformin; Saxagliptin
  • Methadone
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Modafinil
  • Naldemedine
  • Naloxegol
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nateglinide
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Norethindrone
  • Norgestrel
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Osilodrostat
  • Osimertinib
  • Ospemifene
  • Oxycodone
  • Paclitaxel
  • Palbociclib
  • Paliperidone
  • Panobinostat
  • Pazopanib
  • Pemigatinib
  • Perampanel
  • Perindopril; Amlodipine
  • Pexidartinib
  • Pimavanserin
  • Pitolisant
  • Polatuzumab Vedotin
  • Ponatinib
  • Posaconazole
  • Praziquantel
  • Progesterone
  • Progestins
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Regorafenib
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rilpivirine
  • Rimegepant
  • Riociguat
  • Ripretinib
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Roflumilast
  • Rolapitant
  • Romidepsin
  • Ruxolitinib
  • Saquinavir
  • Saxagliptin
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sildenafil
  • Simeprevir
  • Siponimod
  • Sirolimus
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sonidegib
  • Sorafenib
  • Sufentanil
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tamoxifen
  • Tasimelteon
  • Tazemetostat
  • Telithromycin
  • Temsirolimus
  • Teniposide
  • Terbinafine
  • Tezacaftor; Ivacaftor
  • Thiotepa
  • Tiagabine
  • Ticagrelor
  • Tinidazole
  • Tipranavir
  • Tofacitinib
  • Tolvaptan
  • Toremifene
  • Torsemide
  • Trabectedin
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triazolam
  • Tucatinib
  • Ubrogepant
  • Ulipristal
  • Upadacitinib
  • Valbenazine
  • Valproic Acid, Divalproex Sodium
  • Vandetanib
  • Vemurafenib
  • Venetoclax
  • Verapamil
  • Vilazodone
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Warfarin
  • Zaleplon
  • Zanubrutinib
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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