Do some NSAIDs inhibit COX 1 or COX 2 preferentially?
Yes. A classification system is listed below according to the NSAID ability to inhibit COX-1 and/or COX-2 in therapeutic doses.
|Nomenclature||NSAIDs in this Classification|
|COX-1 selective||Low-dose ASA (irreversibly binds to serine 530 on COX-1)|
|COX nonselective||Ibuprofen, naproxen, meclomen, indomethacin|
|COX-2 selective||Etodolac, diclofenac, nabumetone, meloxicam|
|COX-2 highly selective||Celecoxib|