structural classification of NSAIDs

structural classification of NSAIDs

I- Carboxylic acids .

  • A) Salicylates.
    • Acetylated—ASA .a Available over-the-counter (non-acetylated salicylates often come in combination with other ingredients, often in tab or powder form)
    • Nonacetylated—sodium salicylate , magnesium salicylate , salicylamide , salsalate, diflunisal.
  • B) Acetic acids.
    • Indole derivatives—indomethacin, tolmetin, sulindac.
    • Phenylacetic acid—diclofenac.
    • Pyranocarboxylic acid—etodolac.
  • C) Propionic acids—ibuprofen , naproxen , fenoprofen, ketoprofen, flurbiprofen, oxaprozin.
  • D) Fenamic acids—mefenamic acid, meclofenamate sodium.
  • E) Pyrrolizine carboxylic acid derivative—ketorolac.

II -Enolic acids.

  • A) Oxicams—piroxicam, meloxicam.
  • B) Pyrazolones—phenylbutazone (no longer available for human use).
  • III -Nonacidic compounds—nabumetone.
  • IV -Diaryl substituted pyrazoles (COX-2 inhibitors).
    • Celecoxib.
    • Rofecoxib and valdecoxib: withdrawn from market.
    • Etoricoxib, lumiracoxib, and parecoxib (injectable prodrug of valdecoxib): not available in United States/not approved by Food and Drug Administration.
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