structural classification of NSAIDs
I- Carboxylic acids .
- A) Salicylates.
- B) Acetic acids.
- Indole derivatives—indomethacin, tolmetin, sulindac.
- Phenylacetic acid—diclofenac.
- Pyranocarboxylic acid—etodolac.
- C) Propionic acids—ibuprofen a , naproxen a , fenoprofen, ketoprofen, flurbiprofen, oxaprozin.
- D) Fenamic acids—mefenamic acid, meclofenamate sodium.
- E) Pyrrolizine carboxylic acid derivative—ketorolac.
II -Enolic acids.
- A) Oxicams—piroxicam, meloxicam.
- B) Pyrazolones—phenylbutazone (no longer available for human use).
- III -Nonacidic compounds—nabumetone.
- IV -Diaryl substituted pyrazoles (COX-2 inhibitors).
- Celecoxib.
- Rofecoxib and valdecoxib: withdrawn from market.
- Etoricoxib, lumiracoxib, and parecoxib (injectable prodrug of valdecoxib): not available in United States/not approved by Food and Drug Administration.