general properties of NSAIDs
NSAIDs are weak organic acids that avidly bind to serum proteins (mainly albumin). The vast majority have low ionization constants (pKa) ranging from 3 to 5, which accounts for their accumulation at inflammation sites such as arthritic joints (inflamed joints often have a lower pH than clinically uninvolved joints). NSAIDs have antiinflammatory properties by virtue of their inhibition of prostaglandin (PG) synthesis and numerous other mechanisms.
