Diphenhydramine Hydrocodone Phenylephrine

Diphenhydramine Hydrocodone Phenylephrine Brand Names

D-Tann HC | Dytan-HC | Endal HD | Gestuss-HC | Hydro DP | Tusscough HC | Tussinate

What is Diphenhydramine Hydrocodone Phenylephrine

NOTE: These products are discontinued in the U.S.

Diphenhydramine hydrocodone phenylephrine are used together in an oral preparation to relieve cough and congestion due to colds, acute respiratory infections, acute and chronic bronchitis, and seasonal allergies.

The combination product may also be used to help relieve the sneezing and itching associated with hay fever.

Diphenhydramine is a first generation, sedating antihistamine (H1-blocker) of the ethanolamine class. Hydrocodone is an opiate agonist antitussive used for cough suppression.

Phenylephrine is a sympathomimetic agent that relieves nasal and sinus congestion.

Diphenhydramine hydrocodone phenylephrine formulations are available by prescription only.

Indications

1. allergic rhinitis
2. common cold
3. cough
4. eustachian tube congestion
5. nasal congestion
6. sinusitis
7. upper respiratory tract infections

For the symptomatic relief of cough, nasal congestion, eustachian tube congestion due to the common cold, acute upper respiratory tract infections, allergic rhinitis, and sinusitis

Side Effects

1. abdominal pain
2. agitation
3. angina
4. anorexia
5. anxiety
6. appetite stimulation
7. arrhythmia exacerbation
8. asthenia
9. ataxia
10. blurred vision
11. bradycardia
12. colitis
13. confusion
14. constipation
15. diarrhea
16. dizziness
17. drowsiness
18. dysarthria
19. dysphagia
20. dysphoria
21. dyspnea
22. dysuria
23. emotional lability
24. excitability
25. fatigue
26. hallucinations
27. headache
28. hypertension
29. hypotension
30. impaired cognition
31. insomnia
32. irritability
33. lethargy
34. mydriasis
35. nausea
36. ocular hypertension
37. palpitations
38. photophobia
39. photosensitivity
40. polyuria
41. pruritus
42. psychosis
43. pyrosis (heartburn)
44. rash
45. respiratory depression
46. restlessness
47. seizures
48. sinus tachycardia
49. tremor
50. urinary retention
51. vomiting
52. weakness
53. xerophthalmia
54. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute bronchospasm
• alcoholism
• angina
• arteriosclerosis
• asthma
• biliary tract disease
• bladder obstruction
• brain tumor
• breast-feeding
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• ethanol ingestion
• geriatric
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• labor
• MAOI therapy
• neonates
• obstetric delivery
• opiate agonist hypersensitivity
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory insufficiency
• seizure disorder
• seizures
• sleep apnea
• stroke
• substance abuse
• thyrotoxicosis
• urinary retention

Interactions

• Abiraterone
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• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
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• Acetaminophen; Codeine
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• Tedizolid
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Terazosin
• Terbinafine
• Terbutaline
• Tetrabenazine
• Tetracaine
• Tezacaftor; Ivacaftor
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Ticagrelor
• Timolol
• Tipranavir
• Tizanidine
• Tobramycin
• Tolcapone
• Tolterodine
• Topiramate
• Torsemide
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triamcinolone
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vardenafil
• Vasodilators
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Voxelotor
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem