Cyclopentolate Phenylephrine

Cyclopentolate Phenylephrine Brand Name– Cyclomydril

What is Cyclopentolate Phenylephrine

Cyclopentolate and phenylephrine are used together in an ophthalmic preparation for producing mydriasis for ophthalmologic examination.

Cyclopentolate is a cycloplegic mydriatic agent that causes loss of accommodation and mydriasis.

Phenylephrine is a sympathomimetic agent that causes vasoconstriction and mydriasis.

The amount of mydriasis produced by this combination is greater than that produced by either agent alone.

Cyclomydril was approved by the FDA in September 1975


  • mydriasis induction

For mydriasis induction for ophthalmic diagnostic procedures

Side Effects

  1. anhidrosis
  2. ataxia
  3. blurred vision
  4. dysarthria
  5. excitability
  6. fever
  7. hallucinations
  8. hypertension
  9. impaired cognition
  10. keratitis
  11. nasal dryness
  12. ocular irritation
  13. peripheral vasodilation
  14. photophobia
  15. psychosis
  16. restlessness
  17. seizures
  18. sinus tachycardia
  19. urinary retention

Monitoring Parameters

  • ophthalmologic exam


  • breast-feeding
  • cardiac disease
  • cerebral palsy
  • children
  • closed-angle glaucoma
  • contact lenses
  • Down’s syndrome
  • driving or operating machinery
  • geriatric
  • head trauma
  • hypertension
  • hyperthyroidism
  • increased intraocular pressure
  • infants
  • MAOI therapy
  • neonates
  • parenteral administration
  • pregnancy
  • premature neonates
  • seizure disorder
  • sunlight (UV) exposure


There are no drug interactions associated with Cyclopentolate Phenylephrine products.


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