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Dextromethorphan Diphenhydramine Phenylephrine Brand Names
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What is Dextromethorphan Diphenhydramine Phenylephrine
Dextromethorphan diphenhydramine phenylephrine are used together for relief of upper respiratory symptoms such as cough, nasal congestion, and rhinorrhea associated with allergic rhinitis, the common cold, or sinusitis.
Non-prescription day and night-time packaged formulations are often used for relief of upper respiratory symptoms due to the common cold such as cough, nasal congestion, sneezing, itchy, watery eyes, itchy throat, and rhinorrhea.
Dextromethorphan is a centrally acting non-opioid cough suppressant that elevates the threshold for coughing. It is about equal to codeine in depressing the cough reflex.
Diphenhydramine is a first generation sedating antihistamine (H1-blocker) of the ethanolamine class, commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients.
Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.
Indications
- allergic rhinitis
- common cold
- cough
- nasal congestion
- rhinorrhea
- sinusitis
For relief of upper respiratory symptoms such as cough, nasal congestion, and rhinorrhea associated with allergic rhinitis, the common cold, or sinusitis
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- angina
- anorexia
- anxiety
- arrhythmia exacerbation
- ataxia
- blurred vision
- bronchial secretions
- chills
- confusion
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysarthria
- dyspepsia
- dysuria
- euphoria
- excitability
- fatigue
- hallucinations
- headache
- hemolytic anemia
- hypertension
- hypertensive crisis
- hypotension
- insomnia
- irritability
- mydriasis
- myocardial infarction
- nausea
- neuritis
- pallor
- palpitations
- paresthesias
- photophobia
- photosensitivity
- polyuria
- premature ventricular contractions (PVCs)
- pruritus
- psychosis
- rash
- respiratory depression
- restlessness
- seizures
- serotonin syndrome
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- thrombocytopenia
- tinnitus
- tremor
- urinary retention
- urticaria
- vertigo
- visual impairment
- vomiting
- weakness
- wheezing
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute myocardial infarction
- aneurysm
- angina
- anticholinergic medications
- arteriosclerosis
- asthma
- atrial fibrillation
- atrial flutter
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- bronchitis
- bundle-branch block
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- contact lenses
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- emphysema
- geriatric
- GI disease
- GI obstruction
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intraocular pressure
- infants
- intracranial bleeding
- labor
- MAOI therapy
- myocardial infarction
- neonates
- obstetric delivery
- organic brain syndrome
- peptic ulcer disease
- peripheral vascular disease
- phenylketonuria
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- pyloric stenosis
- renal disease
- renal failure
- renal impairment
- status asthmaticus
- stroke
- tachycardia
- thyrotoxicosis
- ulcerative colitis
- urinary retention
- ventricular fibrillation
- ventricular tachycardia
Interactions
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Ambenonium Chloride
- Ambrisentan
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Arformoterol
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-blockers
- Betamethasone
- Betaxolol
- Bethanechol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bretylium
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capecitabine
- Capsaicin; Metaxalone
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carisoprodol
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Ciclesonide
- Cinacalcet
- Citalopram
- Clevidipine
- Clobazam
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Corticosteroids
- Cortisone
- Cyclobenzaprine
- Dacomitinib
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Desloratadine
- Desloratadine; Pseudoephedrine
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxazosin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Dulaglutide
- Duloxetine
- Dutasteride; Tamsulosin
- Dyphylline
- Dyphylline; Guaifenesin
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Escitalopram
- Esketamine
- Esmolol
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Etomidate
- Exenatide
- Ezogabine
- Fedratinib
- Felodipine
- Fenofibric Acid
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Furosemide
- Gabapentin
- Galantamine
- Gentamicin
- Ginger, Zingiber officinale
- Givosiran
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Imatinib
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Ionic Contrast Media
- Isocarboxazid
- Isoflurane
- Isradipine
- Ivacaftor
- Kanamycin
- Ketamine
- Labetalol
- Lasmiditan
- Lemborexant
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lithium
- Lixisenatide
- Lofexidine
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine
- Loratadine; Pseudoephedrine
- Lorazepam
- Lorcaserin
- Loxapine
- Luliconazole
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macitentan
- Magnesium Salts
- Maprotiline
- Mecamylamine
- Meclizine
- Meglitinides
- Melatonin
- Memantine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Metaproterenol
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methylprednisolone
- Methysergide
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrapone
- Metyrosine
- Midazolam
- Midodrine
- Miglitol
- Milnacipran
- Minocycline
- Mirabegron
- Mirtazapine
- Mitotane
- Molindone
- Mometasone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Naproxen; Pseudoephedrine
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nicardipine
- Nicotine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Non-Ionic Contrast Media
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Opiate Agonists
- Oritavancin
- Orphenadrine
- Oxazepam
- Oxycodone
- Oxymorphone
- Oxytocin
- Ozanimod
- Paliperidone
- Panobinostat
- Papaverine
- Paromomycin
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Penbutolol
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine; Promethazine
- Phosphodiesterase inhibitors
- Pimozide
- Pindolol
- Pioglitazone
- Pirbuterol
- Pitolisant
- Plazomicin
- Potassium-sparing diuretics
- Pramipexole
- Pramlintide
- Prazosin
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Pseudoephedrine
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Racepinephrine
- Ramelteon
- Rasagiline
- Remifentanil
- Reserpine
- Riociguat
- Risperidone
- Ritonavir
- Rituximab; Hyaluronidase
- Rivastigmine
- Rolapitant
- Ropinirole
- Rosiglitazone
- Rotigotine
- Safinamide
- Salmeterol
- Secobarbital
- Selegiline
- Selexipag
- Semaglutide
- Serotonin-Receptor Agonists
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Sibutramine
- Sildenafil
- Sincalide
- Sodium Iodide
- Solifenacin
- Solriamfetol
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- St. John’s Wort, Hypericum perforatum
- Streptomycin
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- Tacrine
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- Tamsulosin
- Tapentadol
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- Tedizolid
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- Tezacaftor; Ivacaftor
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- Theophylline, Aminophylline
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- Thiopental
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- Thyroid hormones
- Timolol
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- Topiramate
- Torsemide
- Tramadol
- Trandolapril; Verapamil
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- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trospium
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- Venlafaxine
- Verapamil
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