Dihydrocodeine Guaifenesin Pseudoephedrine

Dihydrocodeine Guaifenesin Pseudoephedrine Brand Names

ColdCough EXP | DiHydro GP | Hydro-Tussin EXP | Pancof EXP | Uni-Cof EXP | WellTuss EXP

What is Dihydrocodeine Guaifenesin Pseudoephedrine

Dihydrocodeine guaifenesin pseudoephedrine are used together in an oral preparation to relieve cough and to facilitate bronchial and sinus drainage. Specifically, this combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, influenza, sinusitis, or bronchitis.

Dihydrocodeine, similar to codeine, is an opiate antitussive used for cough suppression. The antitussive and sedative properties of dihydrocodeine are greater than codeine.

Dihydrocodeine also has analgesic properties, although it is not used for this purpose when combined with guaifenesin and pseudoephedrine.

Guaifenesin has historically been used as an oral expectorant and is thought to be useful for a dry, non-productive cough which tends to injure the respiratory mucous membranes.

Guaifenesin is used to loosen and thin sputum and bronchial secretions and to ease expectoration. Although this action can decrease secretions, indirectly diminishing the tendency to cough, guaifenesin is not considered an antitussive agent.

Pseudoephedrine is a sympathomimetic agent that relieves nasal and sinus congestion. As compared to topically applied sympathomimetics, oral pseudoephedrine produces little or no rebound congestion.

Pseudoephedrine is commonly diverted for use as a substrate for the illegal synthesis of amphetamine and methamphetamine.

The Combat Methamphetamine Epidemic Act of 2005 was established to increase accountability and limit accessibility of common OTC drugs used in the illegal synthesis of methamphetamine; however, this Act does not affect prescription products containing pseudoephedrine.

Dihydrocodeine guaifenesin pseudoephedrine formulations are available by prescription-only.

Indications

1. allergic rhinitis
2. bronchitis
3. common cold
4. cough
5. nasal congestion

For the temporary relief of nasal congestion and dry, non-productive cough associated with upper respiratory tract infections (i.e., bronchitis, common cold) and allergies (i.e., allergic rhinitis)

Side Effects

1. abdominal pain
2. anaphylactoid reactions
3. angina
4. anorexia
5. anxiety
6. arrhythmia exacerbation
7. blurred vision
8. colitis
9. confusion
10. constipation
11. contact dermatitis
12. diaphoresis
13. diarrhea
14. dizziness
15. drowsiness
16. dyspepsia
17. dysuria
18. erythema
19. fatigue
20. flushing
21. hallucinations
22. headache
23. hypertension
24. insomnia
25. interstitial nephritis
26. irritability
27. miosis
28. myocardial infarction
29. nausea
30. nephrolithiasis
31. ocular hypertension
32. orthostatic hypotension
33. palpitations
34. photophobia
35. physiological dependence
36. premature ventricular contractions (PVCs)
37. pruritus
38. psychological dependence
39. psychosis
40. rash
41. renal failure (unspecified)
42. respiratory depression
43. restlessness
44. rhabdomyolysis
45. seizures
46. sinus tachycardia
47. stroke
48. supraventricular tachycardia (SVT)
49. urinary retention
50. vomiting
51. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• angina
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• constipation
• coronary artery disease
• diabetes mellitus
• diarrhea
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• labor
• MAOI therapy
• myocardial infarction
• neonates
• opiate agonist hypersensitivity
• peptic ulcer disease
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal impairment
• respiratory depression
• respiratory infection
• respiratory insufficiency
• sleep apnea
• substance abuse
• tachycardia
• tobacco smoking
• ulcerative colitis
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Tramadol
• Acetazolamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
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• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
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• Dexmedetomidine
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• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
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• Diazepam
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• grapefruit juice
• Green Tea
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• Guaifenesin; Hydrocodone; Pseudoephedrine
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• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
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• Vortioxetine
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem