Chlorpheniramine Dextromethorphan Phenylephrine

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Chlorpheniramine Dextromethorphan Phenylephrine Brand Names

AccuHist PDX | Amerituss DM | Atuss DR | Balamine DM | Cardec DM | Centergy DM | Ceron DM | Ceron-DM | ColdTuss DR | Corfen DM | CP-Dec DM | C-Phen DM | Dec-Chlorphen DM | De-Chlor DM | De-Chlor DR | Dex PC | DM/PE/CPM | Donatussin DM | ED A-HIST DM | ED-A-Hist DM | Endacof | Giltuss Allergy Plus | Giltuss Children’s Allergy Plus | Histadec DM | Maxichlor PEH DM | Maxiphen ADT | Mintuss DM | Mintuss DR | Nasohist-DM | Neo DM | NoHist DM | No-Hist PDX | NoHist-DMX | Norel CS | Norel DM | P CHLOR DM | PD-Cof | PE-Hist DM | Phenabid DM | Poly-Tussin DM | Quartuss DM | RE DCP | Relahist DM | Reme Tussin DM | Rondec DM | Rondex-DM | Sildec PE-DM | Sonahist DM | Statuss DM | TRI-DEX PE | Trigofen DM | Trital DM | TriTuss DM | Tri-Vent DPC | Tuss DM | Tussplex DM | Uni-Tuss DM | Virdec DM | ZoDen DM | Zotex-12D

What is Chlorpheniramine Dextromethorphan Phenylephrine

Chlorpheniramine dextromethorphan phenylephrine are used together in oral preparations to treat cough, congestion, and other symptoms due to the common cold and allergic rhinitis.

Chlorpheniramine is a sedating antihistamine (H1-blocker) of the alkylamine class. Dextromethorphan is a centrally acting non-opioid antitussive.

Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Marketed non-prescription products are available for adults and pediatric patients 6 years of age and older

Indications

  1. allergic rhinitis
  2. common cold
  3. cough
  4. nasal congestion
  5. rhinorrhea
  6. sneezing

For the relief of cough and other symptoms (e.g., rhinorrhea; sinus and nasal congestion; sneezing, itchy eyes, nose, or throat) due to allergic rhinitis or the common cold

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. anorexia
  5. anxiety
  6. aplastic anemia
  7. arrhythmia exacerbation
  8. ataxia
  9. blurred vision
  10. bradycardia
  11. colitis
  12. confusion
  13. constipation
  14. dizziness
  15. drowsiness
  16. dysarthria
  17. dysuria
  18. excitability
  19. hallucinations
  20. headache
  21. hypertension
  22. hypotension
  23. impaired cognition
  24. insomnia
  25. irritability
  26. lethargy
  27. mydriasis
  28. nasal dryness
  29. nausea
  30. ocular hypertension
  31. palpitations
  32. photophobia
  33. psychosis
  34. rash
  35. restlessness
  36. seizures
  37. sinus tachycardia
  38. thrombocytopenia
  39. urinary retention
  40. urticaria
  41. vomiting
  42. weakness
  43. xerophthalmia
  44. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • anticholinergic medications
  • arteriosclerosis
  • asthma
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • bronchitis
  • bundle-branch block
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • emphysema
  • geriatric
  • GI obstruction
  • head trauma
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • labor
  • MAOI therapy
  • neonates
  • obstetric delivery
  • peptic ulcer disease
  • peripheral vascular disease
  • phenylketonuria
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • status asthmaticus
  • thyroid disease
  • thyrotoxicosis
  • tobacco smoking
  • urinary retention
  • ventricular tachycardia

Interactions

  • Abiraterone
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amantadine
  • Ambenonium Chloride
  • Ambrisentan
  • Amikacin
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminoglycosides
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Apomorphine
  • Arformoterol
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Beta-blockers
  • Betamethasone
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Ciclesonide
  • Cinacalcet
  • Citalopram
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Corticosteroids
  • Cortisone
  • Cyclobenzaprine
  • Dacomitinib
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Daratumumab; Hyaluronidase
  • Darifenacin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Dulaglutide
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
  • Esketamine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etomidate
  • Exenatide
  • Ezogabine
  • Fedratinib
  • Felodipine
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Flibanserin
  • Fludrocortisone
  • Flunisolide
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Furosemide
  • Gabapentin
  • Galantamine
  • Gentamicin
  • Ginger, Zingiber officinale
  • Givosiran
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Imatinib
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Ionic Contrast Media
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Kanamycin
  • Ketamine
  • Labetalol
  • Lasmiditan
  • Lemborexant
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Lorcaserin
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Macitentan
  • Magnesium Salts
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Meglitinides
  • Melatonin
  • Memantine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaproterenol
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methohexital
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methylprednisolone
  • Methysergide
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metyrapone
  • Metyrosine
  • Midazolam
  • Midodrine
  • Miglitol
  • Milnacipran
  • Minocycline
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Molindone
  • Mometasone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Naproxen; Pseudoephedrine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Non-Ionic Contrast Media
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Opiate Agonists
  • Oritavancin
  • Orphenadrine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Oxytocin
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Paromomycin
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phenothiazines
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenylephrine; Promethazine
  • Phosphodiesterase inhibitors
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  • Prednisolone
  • Prednisone
  • Pregabalin
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propofol
  • Propoxyphene
  • Propranolol
  • Pseudoephedrine
  • Quazepam
  • Quetiapine
  • Quinine
  • Racepinephrine
  • Ramelteon
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  • Remifentanil
  • Reserpine
  • Riociguat
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  • Ritonavir
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  • Rivastigmine
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  • Safinamide
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  • Secobarbital
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  • Solifenacin
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  • St. John’s Wort, Hypericum perforatum
  • Streptomycin
  • Sufentanil
  • Sulfonylureas
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  • Tacrine
  • Tadalafil
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  • Thalidomide
  • Theophylline, Aminophylline
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  • Tolcapone
  • Torsemide
  • Tramadol
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamcinolone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trospium
  • Umeclidinium; Vilanterol
  • Vardenafil
  • Vasodilators
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Vortioxetine
  • Yohimbine
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem

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