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Dantrolene Brand Names
Dantrium | Revonto | RYANODEX
What is Dantrolene
Dantrolene is an oral and intravenous skeletal muscle relaxant that is the drug of choice for treating malignant hyperthermia.
Although dantrolene is effective for the treatment of chronic spasticity, baclofen is preferred for some patients because of oral dantrolene’s risk of causing hepatotoxicity.
Dantrolene was FDA-approved in January 1974.
An intravenous dantrolene suspension was FDA-approved in July 2014 for the treatment and prevention of malignant hyperthermia.
Advantages of the new formulation include the ability to be rapidly reconstituted and administered, and each vial contains a drug amount sufficient to provide a therapeutic, weight-based, loading dose to many patients
Indications
- malignant hyperthermia
- myalgia
- neuroleptic malignant syndrome
- spasticity
For treatment of chronic spasticity resulting from upper motor neuron disorders (e.g., spinal cord injury, stroke, cerebral palsy, or multiple sclerosis)
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- anorexia
- aplastic anemia
- asthenia
- AV block
- back pain
- blurred vision
- chills
- cirrhosis
- confusion
- constipation
- crystalluria
- depression
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dysphagia
- dysphonia
- dyspnea
- dystonic reaction
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- flushing
- gastritis
- GI bleeding
- headache
- heart failure
- hematuria
- hepatic failure
- hepatitis
- hepatotoxicity
- hyperbilirubinemia
- impotence (erectile dysfunction)
- injection site reaction
- insomnia
- jaundice
- lacrimation
- leukopenia
- malaise
- myalgia
- nausea
- nocturia
- pericarditis
- phlebitis
- photosensitivity
- pleural effusion
- pruritus
- pulmonary edema
- respiratory depression
- seizures
- sinus tachycardia
- thrombocytopenia
- tissue necrosis
- urinary incontinence
- urinary retention
- urticaria
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- LFTs
Contraindications
- breast-feeding
- cardiac disease
- chronic obstructive pulmonary disease (COPD)
- driving or operating machinery
- extravasation
- females
- geriatric
- hepatic disease
- hepatitis
- hepatotoxicity
- multiple sclerosis
- myopathy
- neuromuscular disease
- pregnancy
- pulmonary disease
- sunlight (UV) exposure
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atracurium
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Bacitracin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Calcium-channel blockers
- Cannabidiol
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cisatracurium
- Clemastine
- Clevidipine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyproheptadine
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxacurium
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Enalapril; Felodipine
- Enflurane
- Entacapone
- Esketamine
- Estazolam
- Estrogens
- Eszopiclone
- Ethanol
- Etomidate
- Felodipine
- Fentanyl
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fospropofol
- Gabapentin
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Imipramine
- Isoflurane
- Isradipine
- Ketamine
- Lasmiditan
- Levocetirizine
- Levorphanol
- Lofexidine
- Lorazepam
- Loxapine
- Lumateperone
- Maprotiline
- Meclizine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Methadone
- Methohexital
- Methotrexate
- Methscopolamine
- Midazolam
- Mirtazapine
- Mivacurium
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Neuromuscular blockers
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nortriptyline
- Olanzapine
- Oxazepam
- Oxycodone
- Oxymorphone
- Pancuronium
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Pimozide
- Porfimer
- Pregabalin
- Primidone
- Prochlorperazine
- Promethazine
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Rapacuronium
- Remifentanil
- Riluzole
- Risperidone
- Rocuronium
- Secobarbital
- Sedating H1-blockers
- Sevoflurane
- Sodium Oxybate
- Succinylcholine
- Sufentanil
- Tapentadol
- Temazepam
- Thalidomide
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tolcapone
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Tubocurarine
- Vecuronium
- Verapamil
- Verteporfin
- Zaleplon
- Ziprasidone
- Zolpidem