Dantrolene

Dantrolene Brand Names

Dantrium | Revonto | RYANODEX

What is Dantrolene

Dantrolene is an oral and intravenous skeletal muscle relaxant that is the drug of choice for treating malignant hyperthermia.

Although dantrolene is effective for the treatment of chronic spasticity, baclofen is preferred for some patients because of oral dantrolene’s risk of causing hepatotoxicity.

Dantrolene was FDA-approved in January 1974.

An intravenous dantrolene suspension was FDA-approved in July 2014 for the treatment and prevention of malignant hyperthermia.

Advantages of the new formulation include the ability to be rapidly reconstituted and administered, and each vial contains a drug amount sufficient to provide a therapeutic, weight-based, loading dose to many patients

Indications

  1. malignant hyperthermia
  2. myalgia
  3. neuroleptic malignant syndrome
  4. spasticity

For treatment of chronic spasticity resulting from upper motor neuron disorders (e.g., spinal cord injury, stroke, cerebral palsy, or multiple sclerosis)

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anemia
  5. anorexia
  6. aplastic anemia
  7. asthenia
  8. AV block
  9. back pain
  10. blurred vision
  11. chills
  12. cirrhosis
  13. confusion
  14. constipation
  15. crystalluria
  16. depression
  17. diaphoresis
  18. diarrhea
  19. diplopia
  20. dizziness
  21. drowsiness
  22. dysgeusia
  23. dysphagia
  24. dysphonia
  25. dyspnea
  26. dystonic reaction
  27. elevated hepatic enzymes
  28. erythema
  29. fatigue
  30. fever
  31. flushing
  32. gastritis
  33. GI bleeding
  34. headache
  35. heart failure
  36. hematuria
  37. hepatic failure
  38. hepatitis
  39. hepatotoxicity
  40. hyperbilirubinemia
  41. impotence (erectile dysfunction)
  42. injection site reaction
  43. insomnia
  44. jaundice
  45. lacrimation
  46. leukopenia
  47. malaise
  48. myalgia
  49. nausea
  50. nocturia
  51. pericarditis
  52. phlebitis
  53. photosensitivity
  54. pleural effusion
  55. pruritus
  56. pulmonary edema
  57. respiratory depression
  58. seizures
  59. sinus tachycardia
  60. thrombocytopenia
  61. tissue necrosis
  62. urinary incontinence
  63. urinary retention
  64. urticaria
  65. visual impairment
  66. vomiting
  67. weakness

Monitoring Parameters

  • LFTs

Contraindications

  • breast-feeding
  • cardiac disease
  • chronic obstructive pulmonary disease (COPD)
  • driving or operating machinery
  • extravasation
  • females
  • geriatric
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • multiple sclerosis
  • myopathy
  • neuromuscular disease
  • pregnancy
  • pulmonary disease
  • sunlight (UV) exposure

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atracurium
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Bacitracin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Botulinum Toxins
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium-channel blockers
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cisatracurium
  • Clemastine
  • Clevidipine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyproheptadine
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxacurium
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Enalapril; Felodipine
  • Enflurane
  • Entacapone
  • Esketamine
  • Estazolam
  • Estrogens
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Felodipine
  • Fentanyl
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fospropofol
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Imipramine
  • Isoflurane
  • Isradipine
  • Ketamine
  • Lasmiditan
  • Levocetirizine
  • Levorphanol
  • Lofexidine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Maprotiline
  • Meclizine
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Methadone
  • Methohexital
  • Methotrexate
  • Methscopolamine
  • Midazolam
  • Mirtazapine
  • Mivacurium
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Neuromuscular blockers
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nortriptyline
  • Olanzapine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pancuronium
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenobarbital
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Pimozide
  • Porfimer
  • Pregabalin
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Rapacuronium
  • Remifentanil
  • Riluzole
  • Risperidone
  • Rocuronium
  • Secobarbital
  • Sedating H1-blockers
  • Sevoflurane
  • Sodium Oxybate
  • Succinylcholine
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thalidomide
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tolcapone
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Triprolidine
  • Tubocurarine
  • Vecuronium
  • Verapamil
  • Verteporfin
  • Zaleplon
  • Ziprasidone
  • Zolpidem
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