Cocaine Brand Names- GOPRELTO | NUMBRINO
What is Cocaine
Cocaine is a local anesthetic of the ester type available in a topical solution for application on the mucous membranes of the oral, laryngeal, and nasal cavities.
Cocaine may be abused and lead to physical dependence.
Despite being an excellent local anesthetic, the risk of abuse and the intense local vasoconstriction it produces prevent cocaine from being more widely used clinically.
Indications
- local anesthesia
- mucosal anesthesia
For local anesthesia and/or mucosal anesthesia prior to instrumentation or surgical procedures
Side Effects
- abdominal pain
- agitation
- agnosia
- akathisia
- anxiety
- apnea
- bowel ischemia
- bradycardia
- cardiac arrest
- Cheyne-Stokes respiration
- confusion
- delirium
- diaphoresis
- dizziness
- dysphoria
- dystonic reaction
- emotional lability
- encephalopathy
- epistaxis
- erythrocytosis
- euphoria
- exophthalmos
- fecal incontinence
- fetal death
- fetal distress
- formication
- hallucinations
- headache
- heart failure
- hyperemia
- hyperreflexia
- hypertension
- hyperthermia
- hyporeflexia
- infection
- infertility
- intracranial bleeding
- irritability
- muscle paralysis
- mydriasis
- myocardial infarction
- myoglobinuria
- nasal congestion
- nasal septum perforation
- nausea
- neonatal abstinence syndrome
- ocular irritation
- premature labor
- premature ventricular contractions (PVCs)
- psychological dependence
- psychosis
- pulmonary edema
- pulmonary hypertension
- QT prolongation
- renal failure (unspecified)
- renal tubular obstruction
- respiratory arrest
- respiratory depression
- restlessness
- rhabdomyolysis
- rhinitis
- seizures
- sinus tachycardia
- sinusitis
- sneezing
- spontaneous fetal abortion
- stroke
- tachypnea
- tardive dyskinesia
- tremor
- urinary incontinence
- ventricular fibrillation
- ventricular tachycardia
- vomiting
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- angina
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- coronary artery disease
- geriatric
- heart failure
- hepatic disease
- hypertension
- infants
- infection
- infertility
- myocardial infarction
- nasal trauma
- neonates
- ocular exposure
- ophthalmic administration
- para-aminobenzoic acid, PABA hypersensitivity
- parenteral administration
- pregnancy
- pseudocholinesterase deficiency
- renal disease
- renal failure
- renal impairment
- reproductive risk
- seizure disorder
- seizures
- substance abuse
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Ambenonium Chloride
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amyl Nitrite
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Atazanavir
- Atazanavir; Cobicistat
- Atracurium
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Edrophonium
- Axitinib
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Benzphetamine
- Beta-adrenergic blockers
- Beta-agonists
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupropion
- Bupropion; Naltrexone
- Caffeine; Ergotamine
- Calcium-channel blockers
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Central-acting adrenergic agents
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cholinesterase inhibitors
- Cisatracurium
- Clevidipine
- Clomipramine
- Cobicistat
- Cobimetinib
- Codeine; Phenylephrine; Promethazine
- Daratumumab; Hyaluronidase
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desipramine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diazoxide
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Disulfiram
- Dobutamine
- Donepezil
- Donepezil; Memantine
- Dopamine
- Doxacurium
- Doxepin
- Doxorubicin
- Dronabinol
- Duloxetine
- Edrophonium
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Enflurane
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Ergonovine
- Ergotamine
- Felodipine
- Fenoldopam
- Fexofenadine; Pseudoephedrine
- Galantamine
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halothane
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloprost
- Imipramine
- Isavuconazonium
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isradipine
- Ivabradine
- Lemborexant
- Levodopa
- Levomilnacipran
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linezolid
- Liothyronine
- Lisdexamfetamine
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Maprotiline
- Mecamylamine
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methysergide
- Midodrine
- Milnacipran
- Minocycline
- Minoxidil
- Mirtazapine
- Mivacurium
- Monoamine oxidase inhibitors
- Nabilone
- Naproxen; Pseudoephedrine
- Nefazodone
- Neostigmine
- Neuromuscular blockers
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Norepinephrine
- Nortriptyline
- Ombitasvir; Paritaprevir; Ritonavir
- Pancuronium
- Pemoline
- Pergolide
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Physostigmine
- Potassium-sparing diuretics
- Prilocaine; Epinephrine
- Procarbazine
- Protriptyline
- Pseudoephedrine
- Pyridostigmine
- Racepinephrine
- Rapacuronium
- Reserpine
- Risperidone
- Ritodrine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivastigmine
- Rocuronium
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sevoflurane
- Sibutramine
- Sodium Oxybate
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solriamfetol
- Sparfloxacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Succinylcholine
- Sympathomimetics
- Tacrine
- Tamoxifen
- Tedizolid
- Thiazide diuretics
- Thyroid hormones
- Tramadol
- Trandolapril; Verapamil
- Trastuzumab; Hyaluronidase
- Treprostinil
- Triamterene
- Tricyclic antidepressants
- Trimipramine
- Tubocurarine
- Ubrogepant
- Vasodilators
- Vecuronium
- Venlafaxine
- Verapamil
- Vilazodone
- Vorapaxar
- Vortioxetine
- Ziprasidone
