Cocaine

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Cocaine Brand Names- GOPRELTO | NUMBRINO

What is Cocaine

Cocaine is a local anesthetic of the ester type available in a topical solution for application on the mucous membranes of the oral, laryngeal, and nasal cavities.

Cocaine may be abused and lead to physical dependence.

Despite being an excellent local anesthetic, the risk of abuse and the intense local vasoconstriction it produces prevent cocaine from being more widely used clinically.

Indications

  • local anesthesia
  • mucosal anesthesia

For local anesthesia and/or mucosal anesthesia prior to instrumentation or surgical procedures

Side Effects

  1. abdominal pain
  2. agitation
  3. agnosia
  4. akathisia
  5. anxiety
  6. apnea
  7. bowel ischemia
  8. bradycardia
  9. cardiac arrest
  10. Cheyne-Stokes respiration
  11. confusion
  12. delirium
  13. diaphoresis
  14. dizziness
  15. dysphoria
  16. dystonic reaction
  17. emotional lability
  18. encephalopathy
  19. epistaxis
  20. erythrocytosis
  21. euphoria
  22. exophthalmos
  23. fecal incontinence
  24. fetal death
  25. fetal distress
  26. formication
  27. hallucinations
  28. headache
  29. heart failure
  30. hyperemia
  31. hyperreflexia
  32. hypertension
  33. hyperthermia
  34. hyporeflexia
  35. infection
  36. infertility
  37. intracranial bleeding
  38. irritability
  39. muscle paralysis
  40. mydriasis
  41. myocardial infarction
  42. myoglobinuria
  43. nasal congestion
  44. nasal septum perforation
  45. nausea
  46. neonatal abstinence syndrome
  47. ocular irritation
  48. premature labor
  49. premature ventricular contractions (PVCs)
  50. psychological dependence
  51. psychosis
  52. pulmonary edema
  53. pulmonary hypertension
  54. QT prolongation
  55. renal failure (unspecified)
  56. renal tubular obstruction
  57. respiratory arrest
  58. respiratory depression
  59. restlessness
  60. rhabdomyolysis
  61. rhinitis
  62. seizures
  63. sinus tachycardia
  64. sinusitis
  65. sneezing
  66. spontaneous fetal abortion
  67. stroke
  68. tachypnea
  69. tardive dyskinesia
  70. tremor
  71. urinary incontinence
  72. ventricular fibrillation
  73. ventricular tachycardia
  74. vomiting
  75. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • angina
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coronary artery disease
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • infants
  • infection
  • infertility
  • myocardial infarction
  • nasal trauma
  • neonates
  • ocular exposure
  • ophthalmic administration
  • para-aminobenzoic acid, PABA hypersensitivity
  • parenteral administration
  • pregnancy
  • pseudocholinesterase deficiency
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk
  • seizure disorder
  • seizures
  • substance abuse

Interactions

  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Ambenonium Chloride
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amyl Nitrite
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Aprepitant, Fosaprepitant
  • Articaine; Epinephrine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Edrophonium
  • Axitinib
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzonatate
  • Benzphetamine
  • Beta-adrenergic blockers
  • Beta-agonists
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Central-acting adrenergic agents
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cholinesterase inhibitors
  • Cisatracurium
  • Clevidipine
  • Clomipramine
  • Cobicistat
  • Cobimetinib
  • Codeine; Phenylephrine; Promethazine
  • Daratumumab; Hyaluronidase
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diazoxide
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Disulfiram
  • Dobutamine
  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Doxacurium
  • Doxepin
  • Doxorubicin
  • Dronabinol
  • Duloxetine
  • Edrophonium
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril; Felodipine
  • Enflurane
  • Ephedrine
  • Epinephrine
  • Eplerenone
  • Epoprostenol
  • Ergonovine
  • Ergotamine
  • Felodipine
  • Fenoldopam
  • Fexofenadine; Pseudoephedrine
  • Galantamine
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Halothane
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
  • Iloprost
  • Imipramine
  • Isavuconazonium
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Isradipine
  • Ivabradine
  • Lemborexant
  • Levodopa
  • Levomilnacipran
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linezolid
  • Liothyronine
  • Lisdexamfetamine
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Maprotiline
  • Mecamylamine
  • Mepivacaine; Levonordefrin
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methysergide
  • Midodrine
  • Milnacipran
  • Minocycline
  • Minoxidil
  • Mirtazapine
  • Mivacurium
  • Monoamine oxidase inhibitors
  • Nabilone
  • Naproxen; Pseudoephedrine
  • Nefazodone
  • Neostigmine
  • Neuromuscular blockers
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Nortriptyline
  • Ombitasvir; Paritaprevir; Ritonavir
  • Pancuronium
  • Pemoline
  • Pergolide
  • Perindopril; Amlodipine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Physostigmine
  • Potassium-sparing diuretics
  • Prilocaine; Epinephrine
  • Procarbazine
  • Protriptyline
  • Pseudoephedrine
  • Pyridostigmine
  • Racepinephrine
  • Rapacuronium
  • Reserpine
  • Risperidone
  • Ritodrine
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rocuronium
  • Selective serotonin reuptake inhibitors
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sevoflurane
  • Sibutramine
  • Sodium Oxybate
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solriamfetol
  • Sparfloxacin
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Succinylcholine
  • Sympathomimetics
  • Tacrine
  • Tamoxifen
  • Tedizolid
  • Thiazide diuretics
  • Thyroid hormones
  • Tramadol
  • Trandolapril; Verapamil
  • Trastuzumab; Hyaluronidase
  • Treprostinil
  • Triamterene
  • Tricyclic antidepressants
  • Trimipramine
  • Tubocurarine
  • Ubrogepant
  • Vasodilators
  • Vecuronium
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vorapaxar
  • Vortioxetine
  • Ziprasidone

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