Cobicistat

Sharing is caring!

Cobicistat Brand Name– TYBOST

What is Cobicistat

Cobicistat a CYP3A inhibitor, is indicated for use as a pharmacokinetic enhancer (booster) to increase the systemic exposure of atazanavir or darunavir (in combination with other antiretroviral agents) for the treatment of adults and pediatric patients (weight dependent) with HIV-1 infection.

Health care providers are advised to monitor patients closely for potential drug interactions.

Cobicistat is an inhibitor and substrate for CYP3A4; use with medications that are metabolized by CYP3A4 or that may induce or inhibit CYP3A4 could increase the risk for adverse effects or impaired efficacy.

Indications

  1. human immunodeficiency virus (HIV)
  2. human immunodeficiency virus (HIV) infection

Side Effects

  1. abdominal pain
  2. depression
  3. diarrhea
  4. elevated hepatic enzymes
  5. Fanconi syndrome
  6. fatigue
  7. folliculitis
  8. glycosuria
  9. headache
  10. hematuria
  11. hyperamylasemia
  12. hyperbilirubinemia
  13. hypercholesterolemia
  14. hyperglycemia
  15. hypertriglyceridemia
  16. hypophosphatemia
  17. insomnia
  18. jaundice
  19. maculopapular rash
  20. nausea
  21. nephrolithiasis
  22. neutropenia
  23. pruritus
  24. rash
  25. renal failure (unspecified)
  26. rhabdomyolysis
  27. urticaria
  28. vomiting

Monitoring Parameters

  • CBC with differential
  • CD4+ T cell count
  • hepatitis B serology
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum creatinine
  • serum phosphate
  • urinalysis

Contraindications

  • breast-feeding
  • hepatic disease
  • human immunodeficiency virus (HIV) infection resistance
  • hypophosphatemia
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abemaciclib
  • Acalabrutinib
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Ado-Trastuzumab emtansine
  • Afatinib
  • Aldesleukin, IL-2
  • Alfentanil
  • Alfuzosin
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alogliptin; Metformin
  • Alosetron
  • Alpelisib
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Apixaban
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Armodafinil
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atomoxetine
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Avapritinib
  • Axitinib
  • Azelastine; Fluticasone
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Bepridil
  • Betamethasone
  • Betrixaban
  • Bexarotene
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Bosutinib
  • Brentuximab vedotin
  • Brexpiprazole
  • Brigatinib
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Cabazitaxel
  • Cabozantinib
  • Caffeine; Ergotamine
  • Canagliflozin; Metformin
  • Cannabidiol
  • Capmatinib
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carvedilol
  • Cenobamate
  • Ceritinib
  • Cerivastatin
  • Cevimeline
  • Chloramphenicol
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Ciclesonide
  • Cilostazol
  • Cinacalcet
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobimetinib
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Conjugated Estrogens; Medroxyprogesterone
  • Copanlisib
  • Crizotinib
  • Cyclosporine
  • Dabigatran
  • Dabrafenib
  • Daclatasvir
  • Danazol
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dapsone
  • Darifenacin
  • Darolutamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Deflazacort
  • Delavirdine
  • Desipramine
  • Desvenlafaxine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexlansoprazole
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Docetaxel
  • Dolasetron
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxepin
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride
  • Dutasteride; Tamsulosin
  • Duvelisib
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Eluxadoline
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encainide
  • Encorafenib
  • Enfortumab vedotin
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Erdafitinib
  • Ergotamine
  • Erlotinib
  • Ertugliflozin; Metformin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Eszopiclone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Etonogestrel
  • Etravirine
  • Everolimus
  • Ezetimibe; Simvastatin
  • Fedratinib
  • Felbamate
  • Felodipine
  • Fentanyl
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Flutamide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Formoterol; Mometasone
  • Fosamprenavir
  • Fosphenytoin
  • Fostamatinib
  • Gefitinib
  • Gilteritinib
  • Glasdegib
  • Glecaprevir; Pibrentasvir
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyprogesterone
  • Ibrutinib
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indinavir
  • Irinotecan
  • Irinotecan Liposomal
  • Isavuconazonium
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Istradefylline
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ketoconazole
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lapatinib
  • Larotrectinib
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lemborexant
  • Letermovir
  • Leuprolide; Norethindrone
  • Levomilnacipran
  • Levonorgestrel
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin; Metformin
  • Lomitapide
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Lorlatinib
  • Losartan
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Macitentan
  • Maprotiline
  • Maraviroc
  • Meclizine
  • Medroxyprogesterone
  • Mefloquine
  • Meperidine; Promethazine
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methylergonovine
  • Methylprednisolone
  • Metoclopramide
  • Metoprolol
  • Mexiletine
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Mirabegron
  • Mirtazapine
  • Mitomycin
  • Mitotane
  • Modafinil
  • Mometasone
  • Morphine
  • Morphine; Naltrexone
  • Nafcillin
  • Naldemedine
  • Naloxegol
  • Naloxone
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Neratinib
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Norethindrone
  • Norgestrel
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oritavancin
  • Osilodrostat
  • Ospemifene
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Ozanimod
  • Paclitaxel
  • Palbociclib
  • Palonosetron
  • Panobinostat
  • Paricalcitol
  • Paroxetine
  • Pazopanib
  • Pemigatinib
  • Pentamidine
  • Pentazocine; Naloxone
  • Perampanel
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pirfenidone
  • Pitavastatin
  • Polatuzumab Vedotin
  • Ponatinib
  • Posaconazole
  • Pravastatin
  • Prednisone
  • Primidone
  • Progesterone
  • Promethazine
  • Propafenone
  • Propranolol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ramelteon
  • Ranolazine
  • Regorafenib
  • Repaglinide
  • Retapamulin
  • Revefenacin
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Rilpivirine
  • Rimegepant
  • Ripretinib
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Roflumilast
  • Rolapitant
  • Romidepsin
  • Ropivacaine
  • Rosuvastatin
  • Ruxolitinib
  • Sacubitril; Valsartan
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Segesterone Acetate; Ethinyl Estradiol
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sibutramine
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sirolimus
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sonidegib
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Talazoparib
  • Talimogene Laherparepvec
  • Tamsulosin
  • Tazemetostat
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Teniposide
  • Tenofovir Alafenamide
  • Terbinafine
  • Testosterone
  • Tetrabenazine
  • Tezacaftor; Ivacaftor
  • Theophylline, Aminophylline
  • Thioridazine
  • Thiotepa
  • Tiagabine
  • Ticagrelor
  • Timolol
  • Tinidazole
  • Tipranavir
  • Tofacitinib
  • Tolterodine
  • Tolvaptan
  • Topiramate
  • Topotecan
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triamcinolone
  • Triazolam
  • Tricyclic antidepressants
  • Trimipramine
  • Tucatinib
  • Ubrogepant
  • Ulipristal
  • Umeclidinium; Vilanterol
  • Upadacitinib
  • Valbenazine
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Vorapaxar
  • Voriconazole
  • Voxelotor
  • Warfarin
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Zanubrutinib
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem

Sharing is caring!

You cannot copy content of this page

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top