Clozapine Brand Names
Clozaril | Fazaclo | VERSACLOZ
What is Clozapine
Clozapine is an oral dibenzodiazepine-derived atypical antipsychotic.
Clozapine is structurally related to the antipsychotic loxapine but differs in efficacy and adverse effects.
Approximately 35 mg of clozapine is equivalent to 100 mg of chlorpromazine (CPZ EQ), the prototype typical antipsychotic. Compared to traditional antipsychotics, clozapine has greater limbic system specificity and a low incidence of extrapyramidal side effects.
Clozapine had the distinction of being the first atypical antipsychotic that was proven effective in treating patients with schizophrenia refractory to other medications.
The prescribing information contains a boxed warning regarding the potential for life-threatening severe neutropenia (agranulocytosis); clozapine should be reserved for patients who have failed treatment with two or more trials of other schizophrenia drugs or who are at risk for recurrent suicidal behavior.
Clozapine therapy requires special monitoring and surveillance due to its potential for causing fatal agranulocytosis in about 1% of exposed patients per year; surveillance programs have been effective at reducing the incidence of clozapine-induced agranulocytosis to roughly 0.4% during postmarket use.
The Clozapine REMS Program includes the requirements for monitoring, prescribing, dispensing, and receiving clozapine, and the required management of therapy and monitoring for neutropenia.
Prescribers or their designated agents must enroll each patient into the Clozapine REMS Program prior to patient eligibility to receive the drug. All prescribers and dispensing pharmacies of clozapine are required to be certified by the program.
Indications
- behavioral or psychological symptoms of dementia
- bipolar disorder
- schizoaffective disorder
- schizophrenia
For the treatment of refractory schizophrenia that has failed to respond adequately to appropriate courses of standard antipsychotic agents; also to reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder
Side Effects
- agitation
- agranulocytosis
- akathisia
- akinesia
- amnesia
- anemia
- angina
- angioedema
- anorexia
- anxiety
- apnea
- appetite stimulation
- arrhythmia exacerbation
- asthenia
- ataxia
- atopic dermatitis
- atrial fibrillation
- back pain
- bradycardia
- cardiac arrest
- cardiomyopathy
- chest pain (unspecified)
- chills
- cholestasis
- cirrhosis
- colitis
- confusion
- conjunctival hyperemia
- constipation
- cough
- cyanosis
- delirium
- depression
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- dysmenorrhea
- dyspepsia
- dysphagia
- dyspnea
- dystonic reaction
- edema
- EEG changes
- ejaculation dysfunction
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- eructation
- erythema
- erythema multiforme
- fatigue
- fever
- GI obstruction
- hallucinations
- headache
- heart failure
- hematemesis
- hematoma
- hepatic encephalopathy
- hepatic failure
- hepatic necrosis
- hepatitis
- hepatotoxicity
- hot flashes
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperkinesis
- hypersalivation
- hypertension
- hyperthermia
- hypertriglyceridemia
- hyperuricemia
- hyperventilation
- hyponatremia
- hypotension
- hypothermia
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- insomnia
- interstitial nephritis
- irritability
- jaundice
- laryngitis
- lethargy
- leukocytosis
- leukopenia
- libido decrease
- libido increase
- lupus-like symptoms
- malaise
- mastalgia
- muscle cramps
- myalgia
- myasthenia
- mydriasis
- myocardial infarction
- myocarditis
- myoclonia
- nasal congestion
- nausea
- neuroleptic malignant syndrome
- neutropenia
- neutropenia
- nightmares
- nocturia
- nystagmus
- ocular hypertension
- orthostatic hypotension
- pallor
- palpitations
- pancreatitis
- paranoia
- paresthesias
- peptic ulcer
- pericardial effusion
- pericarditis
- petechiae
- phlebitis
- photosensitivity
- pleural effusion
- polydipsia
- polyuria
- premature ventricular contractions (PVCs)
- priapism
- pruritus
- pseudoparkinsonism
- pseudopheochromocytoma
- psychosis
- pulmonary embolism
- pyrosis (heartburn)
- QT prolongation
- rash
- renal failure (unspecified)
- restlessness
- rhabdomyolysis
- rhinorrhea
- seizures
- SIADH
- sinus tachycardia
- skin hyperpigmentation
- sneezing
- ST-T wave changes
- steatosis
- Stevens-Johnson syndrome
- stroke
- syncope
- tachypnea
- tardive dyskinesia
- throat irritation
- thrombocytopenia
- thrombocytosis
- thrombosis
- torsade de pointes
- tremor
- urinary incontinence
- urinary retention
- urinary urgency
- urticaria
- vasculitis
- ventricular fibrillation
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- water intoxication
- weight gain
- weight loss
- wheezing
- withdrawal
- xerostomia
Monitoring Parameters
- AIMS assessment
- blood glucose
- blood pressure
- CBC with differential
- heart rate
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine
- serum electrolytes
- serum lipid profile
- serum prolactin
- thyroid function tests (TFTs)
- weight
Contraindications
- abrupt discontinuation
- agranulocytosis
- ambient temperature increase
- anticholinergic medications
- apheresis
- AV block
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- cerebrovascular disease
- chemotherapy
- children
- closed-angle glaucoma
- CNS depression
- coadministration with other CNS depressants
- constipation
- dehydration
- dementia
- diabetes mellitus
- diabetic ketoacidosis
- driving or operating machinery
- dysphagia
- ethanol ingestion
- fecal impaction
- females
- fever
- geriatric
- GI obstruction
- heart failure
- hepatic disease
- hepatitis
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hyperosmolar hyperglycemic state (HHS)
- hyperparathyroidism
- hyperthermia
- hypertriglyceridemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypotension
- hypothermia
- hypothyroidism
- hypovolemia
- ileus
- infants
- infection
- jaundice
- leukemia
- leukopenia
- long QT syndrome
- myocardial infarction
- myocarditis
- neonates
- neurological disease
- neutropenia
- obesity
- orthostatic hypotension
- Parkinson’s disease
- phenylketonuria
- pheochromocytoma
- poor metabolizers
- pregnancy
- pregnancy testing
- prostatic hypertrophy
- QT prolongation
- renal failure
- renal impairment
- rheumatoid arthritis
- seizure disorder
- seizures
- sickle cell disease
- sleep deprivation
- strenuous exercise
- stroke
- syncope
- systemic lupus erythematosus (SLE)
- tachycardia
- tardive dyskinesia
- thromboembolic disease
- thromboembolism
- tobacco smoking
- torsade de pointes
- urinary retention
- ventricular arrhythmias
Interactions
- Abarelix
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetazolamide
- Aclidinium; Formoterol
- Ado-Trastuzumab emtansine
- Albendazole
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alkylating agents
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Altretamine
- Amantadine
- Ambenonium Chloride
- Amifampridine
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Antimetabolites
- Antitumor antibiotics
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Armodafinil
- Arsenic Trioxide
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bacillus Calmette-Guerin Vaccine, BCG
- Baclofen
- Bedaquiline
- Belinostat
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendamustine
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Bepridil
- Beta-adrenergic blockers
- Betaxolol
- Bethanechol
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Blinatumomab
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carboplatin
- Carfilzomib
- Cariprazine
- Carisoprodol
- Carmustine, BCNU
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Central-acting adrenergic agents
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorambucil
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Cisplatin
- Citalopram
- Clarithromycin
- Clemastine
- Clobazam
- Clofarabine
- Clofazimine
- Clonazepam
- Clorazepate
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclophosphamide
- Cyproheptadine
- Dacomitinib
- Dalfopristin; Quinupristin
- Danazol
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferiprone
- Degarelix
- Delavirdine
- Denileukin Diftitox
- Desflurane
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Dinutuximab
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Disulfiram
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxazosin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Dulaglutide
- Duloxetine
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encainide
- Encorafenib
- Enflurane
- Entacapone
- Entrectinib
- Enzalutamide
- Epinephrine
- Eplerenone
- Epoprostenol
- Eribulin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eslicarbazepine
- Esmolol
- Estazolam
- Estramustine
- Eszopiclone
- Ethanol
- Ethotoin
- Etomidate
- Etravirine
- Everolimus
- Exenatide
- Ezogabine
- Fedratinib
- Fenoldopam
- Fentanyl
- Fesoterodine
- Fingolimod
- Flecainide
- Fluconazole
- Flucytosine
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Gabapentin
- Galantamine
- Ganirelix
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanidine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyprogesterone
- Hydroxyzine
- Ibritumomab Tiuxetan
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Ipilimumab
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketamine
- Ketoconazole
- Labetalol
- Lamotrigine
- Lapatinib
- Larotrectinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenalidomide
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levodopa
- Levofloxacin
- Levomethadyl
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lithium
- Lixisenatide
- Lofexidine
- Lomefloxacin
- Lomustine, CCNU
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorlatinib
- Loxapine
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Maprotiline
- Mecamylamine
- Meclizine
- Mefloquine
- Meglitinides
- Melphalan
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaproterenol
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methazolamide
- Methocarbamol
- Methohexital
- Methotrexate
- Methylphenidate
- Metoclopramide
- Metoprolol
- Metronidazole
- Mexiletine
- Midazolam
- Midostaurin
- Mifepristone
- Miglitol
- Minoxidil
- Mirabegron
- Mirtazapine
- Mitotane
- Mitoxantrone
- Modafinil
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Nateglinide
- Natural Antineoplastics
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelarabine
- Nelfinavir
- Nevirapine
- Nicardipine
- Nifedipine
- Nilotinib
- Nisoldipine
- Nitroprusside
- Non-Ionic Contrast Media
- Norfloxacin
- Obeticholic Acid
- Obinutuzumab
- Octreotide
- Ofatumumab
- Ofloxacin
- Olanzapine
- Olodaterol
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymorphone
- Ozanimod
- Palbociclib
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Penbutolol
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pertuzumab
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pindolol
- Pioglitazone
- Pirbuterol
- Pitolisant
- Pomalidomide
- Ponatinib
- Posaconazole
- Potassium-sparing diuretics
- Pralatrexate
- Pramipexole
- Pramlintide
- Prazosin
- Pregabalin
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Purine analogs
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Radium-223 Dichloride
- Ramucirumab
- Ranolazine
- Rasagiline
- Remifentanil
- Repaglinide
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rilpivirine
- Risperidone
- Ritonavir
- Rivastigmine
- Rolapitant
- Romidepsin
- Ropinirole
- Rosiglitazone
- Rotigotine
- Rucaparib
- Ruxolitinib
- Safinamide
- Salmeterol
- Saquinavir
- Saxagliptin
- Secobarbital
- Selegiline
- Selpercatinib
- Semaglutide
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Sibutramine
- Siltuximab
- Simeprevir
- Simvastatin; Sitagliptin
- Siponimod
- Sipuleucel-T
- Sitagliptin
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrine
- Tacrolimus
- Tamoxifen
- Tapentadol
- Telaprevir
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Terbinafine
- Terbutaline
- Teriflunomide
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiabendazole
- Thiazide diuretics
- Thiopental
- Thioridazine
- Thiothixene
- Timolol
- Tiotropium; Olodaterol
- Tipranavir
- tobacco
- Tolcapone
- Tolterodine
- Toremifene
- Tositumomab
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Triprolidine
- Triptorelin
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vasopressin, ADH
- Vemurafenib
- Venlafaxine
- Verapamil
- Vismodegib
- Voriconazole
- Vorinostat
- Warfarin
- Zafirlukast
- Zaleplon
- Ziconotide
- Zileuton
- Ziprasidone
- Ziv-Aflibercept
- Zolpidem
- Zonisamide
