Co Enzyme Q10 Ubiquinone Brand Names
Co-Enzyme Q10 | Q-Sorb Co Q-10 | QuinZyme
What is Co Enzyme Q10 Ubiquinone
Coenzyme Q10 (CoQ10), also known as ubiquinone and ubidecarenone, is an endogenously synthesized vitamin-like compound that is involved in a variety of cellular processes.
It is a fat-soluble antioxidant and a member of the quinone family with a structural similarity to vitamin K. Coenzyme Q10 was first isolated from bovine hearts at the University of Wisconsin in 1957; it is found naturally in small amounts in foods, particularly meat and seafood.
Endogenous levels of CoQ10 decline with age. In addition, endogenous deficiencies of CoQ10 have been noted in patients with heart failure, cardiomyopathies, cancer, and some neurological diseases (e.g., Parkinson’s disease).
The use of coenzyme Q10 has been postulated to be of benefit in a variety of disorders; it is possible that a pre-existing state of CoQ10 deficiency may be necessary to observe any clinical benefit from supplementation.
CoQ10 has been studied as an athletic performance enhancer, adjunctive treatment for cardiovascular diseases, acute myocardial infarction, adjuvant treatment for metastatic breast cancer, prophylaxis of doxorubicin-induced cardiomyopathy, familial cerebellar ataxia, periodontal disease, muscular dystrophy, Parkinson’s disease, and mitochondrial disorders.
Most of these uses are based on speculative data or limited, uncontrolled clinical trials.
No firm conclusion can be made in regard to the efficacy of CoQ10 in these conditions, although the controlled data suggest that CoQ10 does not offer benefit to patients with heart failure. The use of CoQ10 for mitochondrial disorders will need controlled trials to support clinical efficacy.
Despite initial studies showing little proof of efficacy, in December 1999, the FDA granted orphan drug status for the treatment of mitochondrial cytopathies to one manufacturer of CoQ10, the GelTec/Tishcon Corporation, for the study of its proprietary supplement UbiQGel. Quinzyme tablets, manufactured by Zyber Pharmaceuticals, are a medical food, and are intended for use under the supervision of physician.
- acute myocardial infarction
- Huntington’s Disease (Huntington’s Chorea)
- migraine prophylaxis
- mitochondrial disease
- nutritional supplementation
- Parkinson’s disease
- elevated hepatic enzymes
Co-enzyme Q10, ubiquinone is generally well-tolerated. Gastric related disturbances, including nausea/vomiting, diarrhea, dyspepsia, and anorexia, may occur. Nausea has been reported as a reason for discontinuing supplementation.
Insomnia and asymptomatic elevated hepatic enzymes have been reported with higher dosages of Co-enzyme Q10, ubiquinone.
- laboratory monitoring not necessary
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