Citric Acid Sodium Citrate

Citric Acid Sodium Citrate Brand Names

Bicitra | Cytra-2 | Liqui-DualCitra | ORACIT | VIRTRATE

What is Citric Acid Sodium Citrate

Citric acid sodium citrate oral solution is a urinary and systemic alkalinizer. Sodium citrates are used for urinary alkalinization to prevent renal stone formation or to treat chronic metabolic acidosis associated with chronic renal insufficiency or renal tubular acidosis.

Sodium citrate salts may be an alternative urinary alkalinizing agent when potassium citrate is contraindicated.

Potassium citrate is generally preferred to sodium citrate for the prevention of renal stones, especially in patients requiring potassium supplementation or those with sodium restrictions.

Once absorbed, citrate salts are metabolized to bicarbonates. Citrate salts have also been used to neutralize or buffer gastric hydrochloric acid prior to anesthesia, however, they have generally been replaced by H2-blockers.

Other commonly used names for citric acid; sodium citrate solutions include Albright’s solution and modified Shohl’s solution.


  1. metabolic acidosis
  2. nephrolithiasis
  3. nephrolithiasis prevention
  4. renal calculus
  5. renal tubular acidosis (RTA)
  6. urinary alkalinization

For urinary alkalinization for nephrolithiasis prevention (due to nephrolithiasis or renal calculus with uric acid or cystine salts or during use of uricosuric agents); or for the treatment of chronic metabolic acidosis associated with renal tubular acidosis (RTA) or other renal tubular disorders

Side Effects

  1. abdominal pain
  2. diarrhea
  3. heart failure
  4. hypernatremia
  5. hyperreflexia
  6. hypertension
  7. hypoventilation
  8. metabolic alkalosis
  9. nausea
  10. peripheral edema
  11. pulmonary edema
  12. seizures
  13. tetany
  14. tremor
  15. vomiting

Monitoring Parameters

  • serum creatinine/BUN
  • serum electrolytes


  • anuria
  • ascites
  • breast-feeding
  • cardiac disease
  • chronic obstructive pulmonary disease (COPD)
  • eclampsia
  • heart failure
  • hepatic disease
  • hypernatremia
  • hypertension
  • hypocalcemia
  • metabolic alkalosis
  • oliguria
  • peripheral edema
  • preeclampsia
  • pregnancy
  • pulmonary edema
  • renal disease
  • renal failure
  • renal impairment


  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amphetamines
  • Antacids
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine
  • Colchicine; Probenecid
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Donepezil; Memantine
  • Ephedrine
  • Fexofenadine; Pseudoephedrine
  • Flecainide
  • food
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Pseudoephedrine
  • Lithium
  • Loratadine; Pseudoephedrine
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Memantine
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Naproxen; Pseudoephedrine
  • Pseudoephedrine
  • Quinidine
  • Quinine
  • Salsalate

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